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Synthesis of Benzyl 4-Hydroxy-5-iodo-2,3-dimethoxy-6-methylbenzoate: The Aromatic Unit of Calicheamicin gamma1

Orsellinic acid (6) was benzylated, and the benzyl 4-benzyloxy-2-hydroxy-6-methylbenzoate (7) was then elaborated into the title compound (2), which is the aromatic constituent of calicheamicin gamma1I.

calicheamicin gamma1I; antitumour; orsellinic acid


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