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Short Reports • J. Braz. Chem. Soc. 27 (6) • June 2016 • https://doi.org/10.5935/0103-5053.20160006   copy

Appel Reaction of Carboxylic Acids with Tribromoisocyanuric Acid/Triphenylphosphine: a Mild and Acid-Free Preparation of Esters and Amides

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A facile and efficient method for esterification and amidation of carboxylic acids under neutral conditions has been developed. Esters and amides can be prepared by reacting a carboxylic acid (1 mmol) with tribromoisocyanuric acid (0.37 mmol) and triphenylphosphine (1 mmol) in dichloromethane at room temperature, followed by addition of an alcohol or an amine, respectively.

Keywords:
amides; esters; tribromoisocyanuric acid; acylation; triphenylphosphine

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