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Pathology • J. Bras. Patol. Med. Lab. 40 (1) • Feb 2004 • https://doi.org/10.1590/S1676-24442004000100010 linkcopy

Open-access Expression of Epstein-Barr virus in patients with Hodgkin's disease: report of 64 cases from Rio de Janeiro, Brazil

Expressão do vírus Epstein-Barr em pacientes com doença de Hodgkin: relato de 64 casos do Rio de Janeiro

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    Epstein-Barr virus (EBV) has been implicated in the pathogenesis of Hodgkin's disease (HD), and the association between EBV and HD is influenced by the patients' socioeconomic status, age and the presence of mixed cellularity (MC) histological subtype. The prevalence of EBV in HD varies widely. This study was undertaken to determine the prevalence of EBV in HD in a Brazilian population. We studied 64 cases with a monoclonal antibody to the EBV latent membrane protein-1 (LMP1). EBV was detected in 35 of the 64 cases (55%) and its presence was significantly correlated with the MC subtype (OR = 9; IC 95% = 1.66 - 66; p = 0,0015). These results support that EBV is related to HD in a Brazilian population.

    Hodgkin's disease; Epstein-Barr virus; LMP1

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    Sociedade Brasileira de Patologia Clínica, Rua Dois de Dezembro,78/909 - Catete, CEP: 22220-040v - Rio de Janeiro - RJ, Tel.: +55 21 - 3077-1400 / 3077-1408, Fax.: +55 21 - 2205-3386 - Rio de Janeiro - RJ - Brazil
    E-mail: jbpml@sbpc.org.br
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