| Present study |
M |
34 |
Lip, buccal mucosa, palate |
Hyperpigmented macules |
Hyperpigmented longitudinal bands in toenails |
| Verma et al. (2017)(88 Verma B, Behra A, Ajmal AK, Sen S. Laugier-Hunziker syndrome in a young female. Indian Dermatol Online J. 2017; 8(2): 148-50.)
|
F |
19 |
Lip, tongue, palate |
Hyperpigmented macules |
Longitudinal melanonychia in finger and toenails |
| Bhoyrul et al. (2016)(99 Bhoyrul B, Paulus J. Macular pigmentation complicating irritant contact dermatitis and viral warts in Laugier-Hunziker syndrome. Clin Exp Dermatol. 2016; 41(3): 294-6.)
|
F |
48 |
Lip |
Several brown to dark macules |
Hyperpigmentation of fingers |
| Kaçar et al. (2016)(1010 Kaçar N, Yildiz CC, Demirkan N. Dermoscopic features of conjunctival, mucosal, and nail pigmentations in a case of Laugier-Hunziker syndrome. Dermatol Pract Concept. 2016; 6(1): 23-4.)
|
M |
23 |
Lip |
Multiple pigmentation |
Longitudinal hyperpigmented bands in nails, punctiform pigmentation in the right eye |
| Lalosevic et al. (2015)(77 Lalosevic J, Zivanovic D, Skiljevic D, Medenica L. Laugier-Hunziker syndrome - case report. An Bras Dermatol. 2015; 90(3): 223-5.)
|
F |
63 |
Buccal mucosa, |
Regular brown pigmentation |
Longitudinal pigmented bands in finger and toenails |
| Mahmood et al. (2015)(33 Mahmood T, Menter A. The Laugier-Hunziker syndrome. Proc (Bayl Univ Med Cent). 2015; 28(1): 41-2.)
|
F |
46 |
Lip |
Hyperpigmented macules |
Longitudinal hyperpigmentation in finger and toenails; isolate macule in the conjunctiva |
| Ergun et al. (2013)(11 Ergun S, Saruhanoğlu A, Migliari DA, Maden I, Tanyeri H. Refractory pigmentation associated with Laugier-Hunziker syndrome following Er:YAG laser treatment. Case Rep Dent. 2013; 2013: 1-4.)
|
F |
37 |
Lip, buccal mucosa, palate |
Brown to dark pigmentation |
- |
| Nikitakis et al. (2013)(55 Nikitakis NG, Koumaki D. Laugier-Hunziker syndrome: case report and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol. 2013; 116(1): 52-8.)
|
F |
55 |
Lip, buccal mucosa |
Multiple oral melanotic macules |
Ill-defined striae in fingernails |
| Wang et al. (2012)(22 Wang WM, Wang X, Duan N, Jiang HL, Huang XF. Laugier-Hunziker syndrome: a report of three cases and literature review. Int J Oral Sci. 2012; 4(4): 226-30.)
|
F |
45 |
Lip, buccal mucosa, gingiva, tongue |
Diffuse hyperpigmentation |
Longitudinal hyperpigmentation in finger and toenails |
| M |
40 |
Gingiva |
Widely diffuse pigmentation |
Brown macule on conjunctiva |
| M |
36 |
Lip |
Multiple oral melanotic macules |
Brown macules in nails and interdigital spaces |
| Wondratsch et al. (2012)(66 Wondratsch H, Feldmann R, Steiner A, Breier F. Laugier-Hunziker syndrome in a patient with pancreatic cancer. Case Rep Dermatol. 2012; 4(2): 174-6.)
|
F |
61 |
Buccal mucosa, tongue |
Confluent pigmented macules |
Hyperpigmentation in vulva |
| Asati et al. (2011)(1111 Asati DP, Tiwari S. Laugier-Hunziker syndrome. Indian J Dermatol Venereol Leprol. 2011; 77(4): 536.)
|
F |
19 |
Lip, buccal mucosa, palate, tongue |
Mild and multiple brown to dark macules, oval to irregular shape |
Multiple freckles in skin of the periorbital region, nose, cheeks, fingertips and nails |
| Ma et al. (2011)(1212 Ma DL, Vano-Galvan S. Hyperpigmentation in Laugier-Hunziker syndrome. CMAJ. 2011; 183(12): 1402.)
|
F |
60 |
Lip, buccal mucosa, tongue |
Diffuse pigmentation |
Longitudinal pigmented bands in nails |
| Sachdeva et al. (2011)(1313 Sachdeva S. Sachdeva S, Kapoor P. Laugier-Hunziker syndrome: a rare cause of oral and acral pigmentation. J Cutan Aesthet Surg. 2011; 4(1): 58-60.)
|
F |
50 |
Lip, tongue |
Brown macules |
Brown macules in finger and toenails; darkened bands in nails |
| Jabbari et al. (2010)(1414 Jabbari A, Gonzalez ME, Franks Jr AG, Sanchez M. Laugier Hunziker syndrome. Dermatol Online J. 2010; 16(11): 23.)
|
F |
45 |
Tongue |
Hyperpigmented macules |
Hyperpigmented macules in nails |
| Montebugn et al. (2010)(1515 Montebugnoli L, Grelli I, Cervellati F, Misciali C, Raone B. Laugier-Hunziker syndrome: an uncommon cause of oral pigmentation and a review of the literature. Int J Dent. 2010; 2010: 1-4.)
|
F |
43 |
Lip, buccal mucosa, |
Diffuse brown macules |
Longitudinal pigmentation in nails |
| Rangwala et al. (2010)(44 Rangwala S, Doherty CB, Katta R. Laugier-Hunziker syndrome: a case report and review of the literature. Dermatol Online J. 2010; 16(12): 9.)
|
M |
77 |
Lip |
Confluent brown macules |
Bilateral melanonychia striata in finger and toenails |
| Sendagorta et al. (2010)(1616 Sendagorta E, Feito M, Ramírez P, Gonzalez-Beato M, Saida T, Pizarro A. Dermoscopic findings and histological correlation of the acral volar pigmented maculae in Laugier-Hunziker syndrome. J Dermatol. 2010; 37(11): 980-4.)
|
F |
76 |
Lip, buccal mucosa, palate, tongue |
Multiple brown to dark lenticular macules |
Linear melanonychia in finger and toenails |
| Tamiya et al. (2010)(1717 Tamiya H, Kamo R, Sowa J, et al. Dermoscopic features of pigmentation in Laugier-Hunziker-Baran syndrome. Dermatol Surg. 2010; 36(1): 152-4.)
|
F |
61 |
Lip, buccal mucosa, |
Slightly brown to grayish blue macules, oval to irregular shape |
Diffuse longitudinal melanonychia |
| Aliagaoglu et al. (2008)(1818 Aliagaoglu C, Yanik ME, Albayrak H, Güvenç SC, Yildirim U. Laugier-Hunziker syndrome: diffuse large hyperpigmentation on atypical localization. J Dermatol. 2008; 35(12): 806-7.)
|
M |
51 |
Lip, buccal mucosa, |
Multiple lenticular dark brown macules |
Increased pigmentation in right pre-tibial area; pigmented macules in palmoplantar region |
| Kim et al. (2008)(1919 Kim EJ, Cho SH, Lee JD. A case of Laugier-Hunziker syndrome. Ann Dermatol. 2008; 20(3): 126-9.)
|
F |
54 |
Lip, buccal mucosa, tongue |
Confluent macules of brown to dark aspect |
Longitudinal melanonychia in nails |
| Yago et al. (2008)(2020 Yago K, Tanaka Y, Asanami S. Laugier-Hunziker-Baran syndrome. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008; 106(2): 20-5.)
|
M |
39 |
Lip, buccal mucosa, tongue, palate |
Multiple hyperpigmented macules |
Well-defined brown macules in palmoplantar regions of toes and toenails |
| M |
68 |
Lip, buccal mucosa, tongue, palate |
Multiple hyperpigmented macules |
Multiple hyperpigmented macules in palmoplantar region; longitudinal pigmented bands in toenails |
| Gencoglan et al. (2007)(2121 Gencoglan G, Gerceker-Turk B, Kilinc-Karaarslan I, Akalin T, Ozdemir F. Dermoscopic findings in Laugier-Hunziker syndrome. Arch Dermatol. 2007; 143(5): 631-5.)
|
F |
24 |
Lip, gingiva, tongue |
Bluish to brown macules |
Longitudinal hyperpigmented macule in the vulva; pigmented macules in palmoplantar area; melanonychia in toenails |
