Sarcoma de células dendríticas foliculares: relato de dois casos e revisão da literaturaRESUMO
Sarcoma de células dendríticas foliculares é uma neoplasia rara, descrita pela primeira vez em 1986 por Monda. Caso 1: Paciente do sexo feminino, 50 anos, realizou tomografia computadorizada de abdômen que detectou lesão tumoral de 8,0 cm em mesentério. Foi submetida à ressecção da lesão. A microscopia revelou neoplasia epitelioide, com linfócitos de permeio e expressão imuno-histoquímica de CD21 e CD35. A paciente foi submetida à quimioterapia adjuvante. Caso 2: Paciente do sexo masculino, 21 anos, com massa cervical direita medindo 7,0 cm. A biópsia evidenciou proliferação de células fusiformes, com infiltrado inflamatório de permeio e arranjo estoriforme, com expressão imuno-histoquímica de CD21 e CD23. O paciente foi submetido a radioterapia neoadjuvante e ressecção cirúrgica.
Unitermos: células dendríticas foliculares; neoplasias de células dendríticas; sarcoma de células dendríticas foliculares; patologia
A) post contrast axial CT image shows a well defined mass near the transverse colon measuring approximately 8.0 cm; B) post contrast sagittal CT scan with mild to moderate heterogeneous enhancement. CT: computed tomography.
Sheets of epithelioid cells with eosinophilic cytoplasm. FDCS: follicular dendritic cell sarcoma.
High magnification shows that the neoplastic cells are epithelioid with ovoid to elongated bland nuclei, distinct nucleolus and eosinophilic cytoplasm. There are numerous small lymphocytes interspersed between tumor cells. FDCS: follicular dendritic cell sarcoma.
A) the tumor has numerous mitoses, some atypical; B) areas of necrosis; C) and D) immunohistochemical staining shows that this neoplasm is positive for CD21 (C) and for fascin (D). FDCS: follicular dendritic cell sarcoma; CD21:
Immunohistochemical staining show that this neoplasm is focal positive for CD45 (A), D2- 40 (B), CD68 (C), and S100 (D). FDCS: follicular dendritic cell sarcoma; CD45: ; D2-40: ; CD68: ; S100: .
Post contrast CT images show a well-defined cervical mass stage II and III on the right side extending to the soft palate measuring approximately 6.0 cm, with moderate heterogeneous enhancement. A) and B) axial CT image; C) sagittal CT image; D) coronal CT image. CT: computed tomography.
Whorling bundles and fascicles of tumor cells are admixed with adjacent lymphoid infiltrates. FDCS: follicular dendritic cell sarcoma.
Spindle tumor cells are admixed with numerous lymphocytes. FDCS: follicular dendritic cell sarcoma.
Immunohistochemical staining shows that this neoplasm is positive for CD21 (A) and CD23 (B). FDCS: follicular dendritic cell sarcoma; CD21: ; CD23: .