| Song et al. (2015)51
|
Animals (Mice) |
Genetic deletion of Ca2+/calmodulin-dependent protein kinase IV impaired contextual fear memory and learning in temporal dissociative passive avoidance task without affecting BDNF transcription |
| Gururajan et al. (2015)52
|
Animals (Rats) |
Heterozygous BDNF knockout rats (but not wild type animals) treated with corticosterone presented significant impairment in extinction learning |
| Wang et al. (2015)53
|
Animals (Mice) |
High-fat diet compared to a regular-fat diet impaired spatial memory aging effects and reduced BDNF levels |
| Gibbons et al. (2014)54
|
Animals (Mice) |
Running wheel increased BDNF expression in dentate gyrus and improved performance in aged mice, while diet containing epigallocatechin-3-gallate and β-alanine had no age-related effect |
| Dincheva et al. (2014)55
|
Animals (Mice) |
In Met allele carriers, contextual fear expression during adolescence is not altered compared to wild type, but in adulthood their performance is worst then wild type |
| Chen et al. (2015)56
|
Animals (Rats) |
Sevoflurane administration during stress reduced the level of BDNF in the hippocampus, while administration after increased BDNF levels compared with the control group |
| Fan et al. (2016)57
|
Animals (Mice) |
Enriched environment attenuated surgery-induced learning deficits mediated by BDNF expression |
| Heldt et al. (2014)58
|
Animals (Mice) |
Appetitive learning (not only fear/aversive learning) is impaired in mice with decreased BDNF expression in the amygdala |
| Schulz-Klaus et al. (2013)59
|
Animals (Rats) |
Expression of BDNF protein in the perirhinal cortex is increased after fear conditioning and is essential for learning effects |
| Psotta et al. (2013)60
|
Animals (Mice) |
Heterozygous BDNF knockout mice, showed similar age-dependent decrease in BDNF levels in brain areas essential for fear extinction and worse fear extinction learning deficits compared to wild type animals |
| Endres and Lessmann (2012)61
|
Animals (Mice) |
Compared to wild type animals, heterozygous BDNF knockout mice |
| Choi et al. (2012)62
|
Animals (Mice) |
TrkB antagonism and viral-mediated BDNF deletion within the prelimbic areas results in decreased of appetitive and aversive emotional learning |
| Meis et al. (2012)63
|
Animals (Mice) |
Heterozygous BDNF knockout mice presented intact cortico-amygdala pathway long-term potentiation, while in the thalamo-amygdala pathway was abolished. Postsynaptic inhibition of TrkB receptors blocked long-term potentiation in the thalamic pathway |
| Uutela et al. (2012)64
|
Animals (Mice) |
Fmr1 knockout mice, an animal model of Fragile X Syndrome, showed declined age-related BDNF levels in the hippocampus and impairment of contextual fear learning |
| Kleschevnikov et al. (2012)65
|
Animals (Mice) |
Treatment with two different GABAB receptor antagonists increased hippocampal levels of BDNF and restored memory of novel place recognition in a genetic model of Down syndrome |
| Oyagi et al. (2011)66
|
Animals (Mice) |
BDNF levels were increased in the cortex, striatum and olfactory bulb of knock-out mice for the heparin-binding epidermal growth factor-like growth factor gene. These knock-out mice showed impairments in spatial memory and fear learning |
| Kimura et al. (2010)67
|
Animals (Mice) |
Both BDNF and TkrB levels were reduced in the hippocampus of heterozygous β-Site amyloid precursor protein cleaving enzyme 1 gene knock-out mice, which is an animal model for Alzheimer’s disease |
| Jin et al. (2009)68
|
Animals (Mice) |
By modulating BDNF and the expression of other factors, fustin flavonoid attenuated amyloid-beta peptide-induced impaired learning |
| Rossato et al. (2009)69
|
Animals (Rats) |
BDNF expression mediated the effect of dopamine receptor manipulation (in the ventral tegmental area of the hippocampus) on long-term memory persistence |
| Woolley et al. (2009)70
|
Animals (Rats) |
Subchronic administration of an AMPA receptor positive modulator elevated BDNF mRNA expression in the dorsal hippocampus, CA1 hippocampal region and vmPFC. Acute administration of the same substance attenuated a scopolamine-induced impairment of cued fear conditioning |
| Bilbo et al. (2008)71
|
Animals (Rats) |
Neonatal infection with E. coli led to decreased BDNF mRNA induction in all hippocampal regions accompanied by a large increase in interleukin-1b mRNA in CA1 hippocampal region |
| Greenwood et al. (2009)72
|
Animals (Rats) |
Six weeks of wheel running increased mRNA in the dentate gyrus, CA1, and the basolateral amygdala. This increase was accompanied by improved contextual fear learning. No effect of wheel running training was observed on fear extinction |
| Gourley et al. (2009)73
|
Animals (Rats) |
A marked decrease in BDNF gene expression in the orbitofrontal cortex was observed following corticosterone exposure |
| Liu et al. (2008)74
|
Animals (Mice) |
Treadmill exercise training transiently increased the BDNF expression in the hippocampus and persistently increased hippocampal levels of TrkB and phosphorylated TrkB. These alterations were positively correlated with passive avoidance performance |
| Bozdagi et al. (2008)75
|
Animals (Mice) |
VGF-derived peptide TLQP62 induced potentiation of CA1 field EPSPs through BDNF-dependent mechanism |
| Chen et al. (2007)76
|
Animals (Rats) |
An NMDA receptor antagonist blocked the increase in the number of BDNF immune reactive hippocampal neurons following fear conditioning and impaired contextual fear learning |
| Ou et al. (2007)77
|
Animals (Rats) |
Administration of actinomycin D or anisomycin blocked fear conditioning and inhibited a conditioning-induced increase in BDNF. Inhibitors for N-methyl-D-aspartate (NMDA) receptor, L-type voltage-dependent calcium channel (L-VDCC), adenylyl cyclase, cAMP-dependent protein kinase (PKA), and calcium/calmodulin-dependent kinase IV (CaMKIV) significantly reduced the increase |
| Jones et al. (2007)78
|
Animals (Mice) |
Mice exposed to trials of unpaired or paired odours and footshocks, showed increased BDNF mRNA expression in the olfactory bulb and anterior piriform cortex when stimuli were unpaired and additionally in the posterior piriform cortex and basolateral amygdala when stimuli were paired |
| Moretti et al. (2006)79
|
Animals (Mice) |
BDNF expression remained unaltered in an animal model of Rett Syndrome that presents memory and learning deficits |
| Aguilar-Valles et al. (2005)80
|
Animals (Rats) |
Increased BDNF gene expression was observed in the hippocampus in response to stress produced by the Morris water-maze paradigm |
| Alonso et al. (2005)81
|
Animals (Rats) |
BDNF expression in the parietal cortex was shown to be essential for both short-term memory and long-term memory formation of inhibitory avoidance learning |
| Chourbaji et al. (2004)82
|
Animals (Mice) |
Mice with a 60% reduction in BDNF expression due to heterozygous gene disruption showed unchanged levels of monoamines, together with normal performance in behavioural tests that investigated anxiety and fear-associated learning. In these mice, choline acetyltransferase activity was significantly reduced in the hippocampus |
| Barrientos et al. (2004)83
|
Animals (Rats) |
Intrahippocampal injection of interleukin 1b impaired contextual fear learning through reduction or blockage of increases of BDNF expression in that region |
| Barrientos et al. (2003)84
|
Animals (Rats) |
Intrahippocampal injection of the interleukin 1b receptor antagonist prevented both the BDNF down regulation and the memory impairments produced by social isolation |
| Gorski et al. (2003)85
|
Animals (Mice) |
Early-onset forebrain-restricted BDNF mutant mice showed impaired learning in the Morris Water Maze. The mice did not present altered sensory processing and gating, measured by the acoustic startle response, nor did they show any alterations in basal anxiety measurements |
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