Qin et al 3434 Qin, X, Cui, Y, Shen, L. Folic acid supplementation and cancer risk: a meta-analysis of randomized controlled trials. Int J Cancer. 2013;133(5):1033–1041. doi:10.1002/ijc.28038. https://doi.org/10.1002/ijc.28038...
|
RCT |
FA supplement |
Total cáncer mortality |
6 |
0.5-4.0 mg FA/day |
3 1.930 |
1.02 |
0.90-1.15 |
Qin et al 3434 Qin, X, Cui, Y, Shen, L. Folic acid supplementation and cancer risk: a meta-analysis of randomized controlled trials. Int J Cancer. 2013;133(5):1033–1041. doi:10.1002/ijc.28038. https://doi.org/10.1002/ijc.28038...
|
RCT |
FA supplement |
Total cáncer incidence |
13 |
0.5-4.0 mg FA/day |
49.406 |
1.05 |
0.99-1.1 1 |
Vollset et al 3535 Vollset, SE, Clarke, R, Lewington, S. Effects of folic acid supplementation on overall and site-specific cancer incidence during the randomised trials: meta-analyses of data on 50,000 individuals. Lancet. 2013;381(9871):1029–1036. doi:10.1016/S0140-6736(12)62001-7. https://doi.org/10.1016/S0140-6736(12)62...
|
RCT |
FA supplement |
Total cáncer incidence |
3 |
0.6-40.0 mg FA/day |
2.652 colorectal adenomas |
1.33 |
0.98-1.80 |
Tio et al 3636 Tio, M, Andrici, J, Cox, MR, Eslick, GD. Folate intake and the risk of upper gastrointestinal cancers: a systematic review and meta-analysis. J Gastroenterol Hepatol. 2014;29(2):250–258. doi:10.1111/jgh.12446. https://doi.org/10.1111/jgh.12446...
|
Case-control |
Folate intake |
Esophageal carcinoma |
4 |
Mean (SD): 276 ± 98 µgfolate/day |
829 cases, 3.977 Controls |
0.63 |
0.44-0.89 |
Tio et al 3636 Tio, M, Andrici, J, Cox, MR, Eslick, GD. Folate intake and the risk of upper gastrointestinal cancers: a systematic review and meta-analysis. J Gastroenterol Hepatol. 2014;29(2):250–258. doi:10.1111/jgh.12446. https://doi.org/10.1111/jgh.12446...
|
Case-control |
Folate intake |
Esophageal adenocarcinoma |
3 |
Mean (SD): 276 ± 98 µgfolate/day |
1.019 cases |
0.57 |
0.43-0.76 |
Tio et al 3636 Tio, M, Andrici, J, Cox, MR, Eslick, GD. Folate intake and the risk of upper gastrointestinal cancers: a systematic review and meta-analysis. J Gastroenterol Hepatol. 2014;29(2):250–258. doi:10.1111/jgh.12446. https://doi.org/10.1111/jgh.12446...
|
Case-control |
Folate intake |
Gastric |
13 |
124-275 µg folate/day |
3.638 cases, 12.530 Controls |
0.87 |
0.70-1.09 |
Tio et al 3636 Tio, M, Andrici, J, Cox, MR, Eslick, GD. Folate intake and the risk of upper gastrointestinal cancers: a systematic review and meta-analysis. J Gastroenterol Hepatol. 2014;29(2):250–258. doi:10.1111/jgh.12446. https://doi.org/10.1111/jgh.12446...
|
Cohort |
Folate intake |
Gastric |
3 |
<258 vs >404 µg FA/day |
776 cases, 197.159 total |
1.19 |
0.92-1.54 |
Tio et al 3636 Tio, M, Andrici, J, Cox, MR, Eslick, GD. Folate intake and the risk of upper gastrointestinal cancers: a systematic review and meta-analysis. J Gastroenterol Hepatol. 2014;29(2):250–258. doi:10.1111/jgh.12446. https://doi.org/10.1111/jgh.12446...
|
Case-control |
Folate intake |
Pancreatic |
8 |
<247 vs >396 µg folate/day, |
2.209 cases, 295.526 Controls |
0.66 |
0.49-0.89 |
|
|
|
|
|
|
<247 vs >738 µg FA/day |
|
|
|
Tio et al 3636 Tio, M, Andrici, J, Cox, MR, Eslick, GD. Folate intake and the risk of upper gastrointestinal cancers: a systematic review and meta-analysis. J Gastroenterol Hepatol. 2014;29(2):250–258. doi:10.1111/jgh.12446. https://doi.org/10.1111/jgh.12446...
|
Cohort |
Folate intake |
Pancreatic |
5 |
< 176 vs >396 µg folate/day |
1.247 cases, 291.950 |
0.65 |
0.38-1.1 1 |
Tio et al 3636 Tio, M, Andrici, J, Cox, MR, Eslick, GD. Folate intake and the risk of upper gastrointestinal cancers: a systematic review and meta-analysis. J Gastroenterol Hepatol. 2014;29(2):250–258. doi:10.1111/jgh.12446. https://doi.org/10.1111/jgh.12446...
|
Case-control |
Plasma |
Pancreatic |
4 |
<9 to >20 nmol/L |
839 cases, 2.215 Controls |
0.73 |
0.47-1.13 |
Chuang et al 3232 Chuang, SC, Rota, M, Gunter, MJ. Quantifying the dose-response relationship between circulating folate concentrations and colorectal cancer in cohort studies: a meta-analysis based on a flexible meta-regression model. Am J Epidemiol. 2013;178(7):1028–1037. doi:10.1093/aje/kwt083. https://doi.org/10.1093/aje/kwt083...
|
Nested case-control |
Plasma |
Colorectal |
8 |
4.8-70.9 nmol/L |
3.477 cases, 1.039 Controls |
0.96 |
0.91-1.02 |
Qin et al 3737 Qin, T, Du, M, Du, H, Shu, Y, Wang, M, Zhu, L. Folic acid supplements and colorectal cancer risk: meta-analysis of randomized controlled trials. Sci Rep. 2015;5:12044. doi:10.1038/srep12044. https://doi.org/10.1038/srep12044...
|
RCT |
FA supplement |
Colorectal |
8 |
0.5-2.5 mg FA/day |
|
1.01 |
0.82-1.22 |
Qin et al 3737 Qin, T, Du, M, Du, H, Shu, Y, Wang, M, Zhu, L. Folic acid supplements and colorectal cancer risk: meta-analysis of randomized controlled trials. Sci Rep. 2015;5:12044. doi:10.1038/srep12044. https://doi.org/10.1038/srep12044...
|
RCT |
FA supplement |
Colorectal |
6 |
0.5-2.5 mg FA/day |
184 cases/16.926 treatment group, 183 cases/16.899 control |
1.01 |
0.82-1.23 |
Qin et al 3737 Qin, T, Du, M, Du, H, Shu, Y, Wang, M, Zhu, L. Folic acid supplements and colorectal cancer risk: meta-analysis of randomized controlled trials. Sci Rep. 2015;5:12044. doi:10.1038/srep12044. https://doi.org/10.1038/srep12044...
|
RCT |
FA supplement |
Breast |
4 |
<1 vs > 1 mg FA/day |
19.800 |
0.82 |
0.63-1.07 |
Chen et al 3838 Chen, P, Li, C, Li, X, Li, J, Chu, R, Wang, H. Higher dietary folate intake reduces the breast cancer risk: a systematic review and meta-analysis. Br J Cancer. 2014;110(9):2327–2338. doi:10.1038/bjc.2014.155. https://doi.org/10.1038/bjc.2014.155...
|
Cohort |
Folate intake |
Breast |
16 |
244 vs 422 µg folate/day |
744.068 |
0.95 |
0.87-1.03 |
Chen et al 3838 Chen, P, Li, C, Li, X, Li, J, Chu, R, Wang, H. Higher dietary folate intake reduces the breast cancer risk: a systematic review and meta-analysis. Br J Cancer. 2014;110(9):2327–2338. doi:10.1038/bjc.2014.155. https://doi.org/10.1038/bjc.2014.155...
|
Case-control |
Folate intake |
Breast |
26 |
129-975 µg folate/day |
16.826 cases, 21.820 Controls |
0.79 |
0.67-0.92 |
Qin et al 3737 Qin, T, Du, M, Du, H, Shu, Y, Wang, M, Zhu, L. Folic acid supplements and colorectal cancer risk: meta-analysis of randomized controlled trials. Sci Rep. 2015;5:12044. doi:10.1038/srep12044. https://doi.org/10.1038/srep12044...
|
RCT |
FA supplement |
Lung |
5 |
0.5-4.0 mg FA/day |
3 1.864 |
1.00 |
0.84-1.21 |
Vieira et al 3939 Vieira, AR, Abar, L, Vingeliene, S. Fruits, vegetables and lung cancer risk: a systematic review and meta-analysis. Ann Oncol. 2016;27(1):81–96. doi:10.1093/annonc/mdv381. https://doi.org/10.1093/annonc/mdv381...
|
Cohort |
Folate intake |
Lung |
9 |
244 vs 422 µg folate/day |
566.921 |
0.92 |
0.84-1.01 |
Dai et al 4040 Dai, W-M, Yang, B, Chu, X-Y. Association between folate intake, serum folate levels and the risk of lung cancer: a systematic review and meta-analysis. Chin Med J (Engl). 2013;126(10):1957–1964.
|
Case-control |
Folate intake |
Lung |
6 |
Not available |
4.390 cases, 6.138 Controls |
0.74 |
0.65-0.84 |
Dai et al 4040 Dai, W-M, Yang, B, Chu, X-Y. Association between folate intake, serum folate levels and the risk of lung cancer: a systematic review and meta-analysis. Chin Med J (Engl). 2013;126(10):1957–1964.
|
Case-control |
Serum folate |
Lung |
4 |
Not available |
1.438 cases, 2.582 Controls |
0.78 |
0.60-1.02 |
Zhou et al 4141 Zhou, X, Meng, Y. Association between serum folate level and cervical cancer: a meta-analysis. Arch Gynecol Obstet. 2016;293(4):871–877. doi:10.1007/s00404-015-3852-3855. https://doi.org/10.1007/s00404-015-3852-...
|
Case-control |
Serum folate |
Cervix |
6 |
Range of deficient criteria: |
873 cases, 1.510 Controls |
0.97 |
0.65-1.45 |
|
|
|
|
|
|
< 1.5 to <6.4 ng/mL |
|
|
|
Wang et al 4242 Wang, R, Zheng, Y, Huang, J-Y, Zhang, A-Q, Zhou, Y-H, Wang, J-N. Folate intake, serum folate levels, and prostate cancer risk: a meta-analysis of prospective studies. BMC Public Health. 2014;14:1326. doi:10.1186/1471-2458-14-1326. https://doi.org/10.1186/1471-2458-14-132...
|
Cohort |
Folate intake |
Prostate |
5 |
177 vs 413 µg folate/day |
192.702 |
1.02 |
0.95-1.09 |
Wang et al 4242 Wang, R, Zheng, Y, Huang, J-Y, Zhang, A-Q, Zhou, Y-H, Wang, J-N. Folate intake, serum folate levels, and prostate cancer risk: a meta-analysis of prospective studies. BMC Public Health. 2014;14:1326. doi:10.1186/1471-2458-14-1326. https://doi.org/10.1186/1471-2458-14-132...
|
Cohort |
Serum folate |
Prostate |
5 |
<4.8 vs >17.5 nmol/L |
192.702 |
1.21 |
1.05-1.39 |