Analysis of the prevalence and influencing factors of hyperuricemia in children and adolescents aged 6-17 years in northeastern Sichuan Province

Guo, Xuemei; Xiao, Ningting; Jing, Xueming; Zhu, Zhennan; Zhang, Heping

doi:10.1016/j.jped.2023.05.001

Acessibilidade / Reportar erro

Brasil

Español English

sumário « anterior atual seguinte »

Sumário

ORIGINAL ARTICLE • J. Pediatr. (Rio J.) 99 (6) • 2023 • https://doi.org/10.1016/j.jped.2023.05.001 copy

Analysis of the prevalence and influencing factors of hyperuricemia in children and adolescents aged 6-17 years in northeastern Sichuan Province

Authorship SCIMAGO INSTITUTIONS RANKINGS

Abstract

Objective:

To investigate the factors influencing hyperuricemia in children and adolescents and to provide a scientific basis for early prevention and treatment.

Methods:

A retrospective study (2017-2021) of the prevalence of hyperuricemia in children and adolescents was conducted, and the factors influencing hyperuricemia were analyzed by multifactor logistic regression.

Results:

The overall prevalence of hyperuricemia in children and adolescents aged 6-17 years in northeast Sichuan Province was 55.12% (8676/15,739), of which 60.68% (5699/9392) in boys and 46.90% (2977/6347) in girls; the prevalence of hyperuricemia from 2017 to 2021 was 52.40% ( 1540/2939), 52.56% (1642/3124), 52.11% (1825/3502), 58.33% (1691/2899), and 60.40% (1978/ 3275), respectively; the prevalence rates of 6-12 years old were 48.92% (864/1766), 50.46% (769/1524), and 52.73% (685/1299), 56.99% (693/1216), 35.46% (444/1252), 46.33% (524/1131), 60.50% (720/1190), and 66.82% (739/1106), 58.95% (652/1106), and 62.17% (761/1106) for 13-17 years old, respectively, 62.17% (761/1224), 63.19% (855/1353), and 61.70% (970/1572), respectively. Logistic regression showed that the prevalence of male (OR = 1.451, 95% CI 1.034 to 2.035, p = 0.031), age (OR = 1.074, 95% CI 1.024 to 1.126, p = 0.003), overweight/obesity (OR = 1.733, 95% CI 1.204~2.494, p = 0.003), blood creatinine (OR = 1.018, 95% CI 1.005~1.031, p = 0.007), triglycerides (OR = 1.450, 95% CI1.065~1.972, p = 0.018), blood calcium (OR = 6.792, 95% CI 1.373~33.594, p = 0.019), and systolic blood pressure (OR = 1.037, 95% CI 1.018~1.057, p < 0.001) were influential factors for the development of hyperuricemia.

Conclusion:

The prevalence of hyperuricemia was higher in children and adolescents aged 6-17 years in northeastern Sichuan Province, with a higher prevalence in boys than in girls, and the prevalence increased with age.

KEYWORDS
Children; Adolescents; Hyperuricemia; Prevalence; Influencing factors

Indicators	Hyperuricemia group (8676 cases)	No hyperuricemia group (7063 cases)	χ² /t	P
Gender (male, n)	5699 (65.68)	3693 (52.28)	–3.807	<0.001
Age (years)	12.53±3.79	11.37±4.04	–3.856	<0.001
Body mass index Kg/m² (overweight/obese, n)	4754 (54.79)	2589 (36.65)	5.575	0.018
Systolic blood pressure (mmHg)	112.82±11.70	107.44±11.61	–5.977	<0.001
Diastolic blood pressure (mmHg)	72.08±9.59	69.48±9.66	–3.500	<0.001
Leukocytes (×10⁹9 Lee JH. Prevalence of hyperuricemia and its association with metabolic syndrome and cardiometabolic risk factors in Korean children and adolescents: analysis based on the 2016-2017 Korea National Health and Nutrition Examination Survey. Korean J Pediatr. 2019;62:317-23. /L)	8.01±3.95	7.73±3.23	–1.001	0.317
Red blood cells (×10¹²12 Zhang C, Li L, Zhang Y, Zeng C. Recent advances in fructose intake and risk of hyperuricemia. Biomed Pharmacother. 2020;131:110795. /L)	4.79±0.59	4.61 ±0.53	–4.057	<0.001
Hemoglobin (g/L)	137.45±17.03	130.30±16.97	–5.458	<0.001
Albumin (g/L)	44.68±4.90	43.82±4.10	–2.410	0.016
Pre-albumin (mg/L)	226.67±71.65	196.18±74.59	–5.435	<0.001
Blood creatinine (umol/L)	54.35±18.18	46.03±15.90	–6.232	<0.001
Urea nitrogen (mmol/L)	4.39±1.31	4.04±1.24	–3.555	<0.001
Blood uric acid (umol/L)	421.06±93.29	260.41 ±56.21	–25.747	<0.001
Glomerular filtration rate (ml/min/1.73m² )	201.30±93.80	249.30±112.61	6.139	<0.001
Homocysteine (umol/L)	11.22±7.54	9.59±5.54	–3.091	0.002
Cystatin C (mg/L)	0.85±0.19	0.77±0.14	–5.320	<0.001
Total cholesterol (mmol/L)	4.01±1.33	3.86±0.88	–1.581	0.114
Triglycerides (mmol/L)	1.12±0.79	0.91 ±0.70	–3.719	<0.001
High-density lipoprotein (mmol/L)	1.24±0.40	1.34±0.35	3.204	0.001
Low-density lipoprotein (mmol/L)	2.18±0.93	2.01 ±0.65	–2.592	0.010
Apolipoprotein A (g/L)	1.17±0.26	1.19±0.23	0.596	0.552
Blood potassium (mmol/L)	4.03±0.40	3.99±0.33	–1.312	0.190
Blood phosphorus (mmol/L)	1.44±0.29	1.43±0.28	–0.159	0.874
Blood magnesium (mmol/L)	0.85±0.07	0.85±0.07	0.617	0.538
Blood calcium (mmol/L)	2.41±0.12	2.38±0.11	–2.533	0.012
Ultrasensitive C-reactive protein (mg/L)	1.25 (0.35,6.09)	1.41 (0.28,9.42)	1.609	0.108
Fasting blood glucose (mmol/L)	5.35±1.90	5.18±1.27	–1.244	0.214

Variables	β	SE	Wald×2	P	OR	95%cl
Constants	–10.651	1.960	29.525	–	–	–
Gender, Male	0.372	0.173	4.635	0.031	1.451	1.034–2.035
Age	0.071	0.024	8.623	0.003	1.074	1.024–1.126
Body mass index, overweight/obese	0.550	0.186	8.760	0.003	1.733	1.204–2.494
Blood creatinine	0.018	0.007	7.278	0.007	1.018	1.005–1.031
Triglycerides	0.371	0.157	5.584	0.018	1.450	1.065–1.972
Blood Calcium	1.916	0.816	5.516	0.019	6.792	1.373–33.594
Systolic pressure	0.037	0.010	14.440	<0.001	1.037	1.018–1.057

Sociedade Brasileira de Pediatria Av. Carlos Gomes, 328 cj. 304, 90480-000 Porto Alegre RS Brazil, Tel.: +55 51 3328-9520 - Porto Alegre - RS - Brazil
E-mail: jped@jped.com.br

Acompanhe os números deste periódico no seu leitor de RSS

[1] * Corresponding author. E-mail: 752685221@qq.com (X. Guo).