Su et al. 20132121 Su F, Nicolson SC, Zuppa AF. A dose-response study of dexmedetomidine administered as the primary sedative in infants following open heart surgery. Pediatr Crit Care Med. 2013;14:499–507.
|
36 |
8.3 ± 3.5 |
0.35μg/kg, 0.7μg/kg, 1μg/kg loading dose with infusion rate of 0.25 μg/kg/h, 0.50 μg/kg/h, 0.75μg/kg/h respectively |
Chrysostomou et al. 20092222 Chrysostomou C, Sanchez De Toledo J, Avolio T, et al. Dexmedetomidine use in a pediatric cardiac intensive care unit: can we use it in infants after cardiac surgery? Pediatr Crit Care Med. 2009;10:654-60. Erratum in: Pediatr Crit Care Med. 2012;13:373.
|
80 |
3.9 ± 3.0 |
0.10–1.25 μg/kg/h infusion |
Lam et al. 20122323 Lam F, Bhutta AT, Tobias JD, Gossett JM, Morales L, Gupta P. Hemodynamic effects of dexmedetomidine in critically ill neonates and infants with heart disease. Pediatr Cardiol. 2012;33:1069–77.
|
50 |
3.5 ± 2.6 |
0.10–1.50 μg/kg/h infusion |
Chrysostomou et al. 20062424 Chrysostomou C, Di Filippo S, Manrique AM, et al. Use of dexmedetomidine in children after cardiac and thoracic surgery. Pediatr Crit Care Med. 2006;7:126–31.
|
19 |
96.0 ± 12.2 |
0.20, 0.40, 0.60 μg/kg/h infusion |
Chen et al. 20132525 Chen L, Meng XH. Effects of dexmedetomidine on stress response in pediatric cardiac surgery with cardiopulmonary bypass. China Modern Doctor. 2013;51:35.
|
40 |
36.0 ± 24.0 |
0.50 μg/kg loading dose with constant speed infusion in 10 min; 0.50 μg/kg/h infusion |
Lazol et al. 20102626 Lazol JP, Lichtenstein SE, Jooste EH, et al. Effect of dexmedetomidine on pulmonary artery pressure after congenital cardiac surgery: a pilot study. Pediatr Crit Care Med. 2010;11:589–92.
|
22 |
10.0 ± 92.0 |
from 0.50 μg/kg to 1.00 μg/kg, infused at a rate of 0.10 μg/kg/min |
Mukhtar et al. 20062727 Mukhtar AM, Obayah EM, Hassona AM. The use of dexmedetomidine in pediatric cardiac surgery. Anesth Analg. 2006;103:52–6. table of contents.
|
30 |
28.0 ± 13.0 |
0.50 μg/kg loading dose with constant speed infusion in 10 min |
Jooste et al. 20102828 Jooste EH, Muhly WT, Ibinson JW, et al. Acute hemodynamic changes after rapid intravenous bolus dosing of dexmedetomidine in pediatric heart transplant patients undergoing routine cardiac catheterization. Anesth Analg. 2010;111:1490–6.
|
12 |
74.0 ± 26.5 |
0.50 μg/kg loading dose in five seconds |
Chen et al. 20142929 Chen Q, Wu W, Zhang GC, et al. Dexmedetomidine attenuates hypoxemia during palliative reconstruction of the right ventricular outflow tract in pediatric patients. Medicine. 2014;93: e69.
|
25 |
11.7 ± 3.9 |
from 0.20 to 0.30 μg/kg/h with a 0.30 μg/kg loading dose |
Hammer et al. 20083030 Hammer GB, Drover DR, Cao H, et al. The effects of dexmedetomidine on cardiac electrophysiology in children. Anesth Analg. 2008;106:79–83. table of contents.
|
12 |
156.0 ± 6.0 |
1.00 μg/kg/h for 10 min, followed by 0.70 μg/kg/h for 10 min. |
Chrysostomou et al. 20113131 Chrysostomou C, Sanchez-de-Toledo J, Wearden P, et al. Perioperative use of dexmedetomidine is associated with decreased incidence of ventricular and supraventricular tachyarrhythmias after congenital cardiac operations. Ann Thorac Surg. 2011;92:964–72. discussion 972.
|
32 |
4.8 (0.16-198) |
0.1–1.5 μg/kg/h infusion |
Kadam et al. 20153232 Kadam SV, Tailor KB, Kulkarni S, Mohanty SR, Joshi PV, Rao SG. Effect of dexmeditomidine on postoperative junctional ectopic tachycardia after complete surgical repair of tetralogy of Fallot: A prospective randomized controlled study. Ann Card Anaesth. 2015;18:323–8.
|
46 |
38.1 ± 62.4 |
0.75 μg/kg/h infusion after a loading dose of 1 mcg/kg over 15 min |
Rajput et al. 20143333 Rajput RS, Das S, Makhija N, Airan B. Efficacy of dexmedetomidine for the control of junctional ectopic tachycardia after repair of tetralogy of Fallot. Ann Pediatr Cardiol. 2014;7:167–72.
|
110 |
33.2 ± 18.8 |
0.5 μg/kg over 10 min followed by a continuous infusion of 0.5 μg/ kg/h. |
Shuplock et al. 20153434 Shuplock JM, Smith AH, Owen J, et al. Association between perioperative dexmedetomidine and arrhythmias after surgery for congenital heart disease. Circ Arrhythm Electrophysiol. 2015;8:643–50.
|
468 |
26.1 (5.8 59.8) |
0.5 – 0.84 μg/kg/h infusion |
Amrousy et al. 20173535 El Amrousy DM, Elshmaa NS, El-Kashlan M, et al. Efficacy of prophylactic dexmedetomidine in preventing postoperative junctional ectopic tachycardia after pediatric cardiac surgery. J Am Heart Assoc. 2017;6:e004780.
|
60 |
17.3 ± 4.1 |
0.5 μg/kg over 20 min followed by a continuous infusion of 0.5 μg/ kg/h. |