Bunodosoma caissarum
|
BcsTx1 |
fKv1.2 |
4.15 |
0.03 |
|
|
|
[4949. Orts DJ, Peigneur S, Madio B, Cassoli JS, Montandon GG, Pimenta AM, Bicudo JE, Freitas JC, Zaharenko AJ, Tytgat J. Biochemical and electrophysiological characterization of two sea anemone type 1 potassium toxins from a geographically distant population of Bunodosoma caissarum. Mar Drugs. 2013 Mar 6;11(3):655-79. doi: 10.3390/md11030655. https://doi.org/10.3390/md11030655...
] |
Bunodosoma caissarum
|
BcsTx2 |
Kv1.6 |
3.91 |
7.76 |
|
|
|
[4949. Orts DJ, Peigneur S, Madio B, Cassoli JS, Montandon GG, Pimenta AM, Bicudo JE, Freitas JC, Zaharenko AJ, Tytgat J. Biochemical and electrophysiological characterization of two sea anemone type 1 potassium toxins from a geographically distant population of Bunodosoma caissarum. Mar Drugs. 2013 Mar 6;11(3):655-79. doi: 10.3390/md11030655. https://doi.org/10.3390/md11030655...
] |
Conus spurius
|
sr11a |
Kv1.6 |
3.65 |
640.00 |
|
|
|
[9494. Aguilar MB, Pérez-Reyes LI, López Z, de la Cotera EP, Falcón A, Ayala C, Galván M, Salvador C, Escobar LI. Peptide sr11a from Conus spurius is a novel peptide blocker for Kv1 potassium channels. Peptides. 2010 Jul;31(7):1287-91. doi: 10.1016/j.peptides.2010.04.007. https://doi.org/10.1016/j.peptides.2010....
] |
Conus princeps
|
PiVIIA |
gICaT, ICaN
|
3.09 |
c3,000.00 |
|
|
|
[9595. Bernáldez J, Jiménez S, González LJ, Ferro JN, Soto E, Salceda E, Chávez D, Aguilar MB, Licea-Navarro A. A New Member of Gamma-Conotoxin Family Isolated from Conus princeps Displays a Novel Molecular Target. Toxins (Basel). 2016 Feb 5;8(2):39. doi: 10.3390/toxins8020039. https://doi.org/10.3390/toxins8020039...
] |
Bothrops alternatus
|
BaltCRP |
Kv1.1 |
24.40 |
|
1,000.00 |
|
|
[4848. Bernardes CP, Menaldo DL, Zoccal KF, Boldrini-França J, Peigneur S, Arantes EC, Rosa JC, Faccioli LH, Tytgat J, Sampaio SV. First report on BaltCRP, a cysteine-rich secretory protein (CRISP) from Bothrops alternatus venom: Effects on potassium channels and inflammatory processes. Int J Biol Macromol. 2019 Nov 1;140:556-567. doi: 10.1016/j.ijbiomac.2019.08.108. https://doi.org/10.1016/j.ijbiomac.2019....
] |
Heloderma suspectum
|
Exendin-4 |
Kv
|
4.19 |
|
10.00 |
|
|
[159159. MacDonald PE, Salapatek AM, Wheeler MB. Glucagon-like peptide-1 receptor activation antagonizes voltage-dependent repolarizing K(+) currents in beta-cells: a possible glucose-dependent insulinotropic mechanism. Diabetes. 2002 Dec;51 Suppl 3:S443-7. doi: 10.2337/diabetes.51.2007.s443. https://doi.org/10.2337/diabetes.51.2007...
] |
Heloderma suspectum
|
Exendin-4 |
hICaL
|
4.19 |
|
0.10 |
|
|
[160160. Wang YC, Wang L, Shao YQ, Weng SJ, Yang XL, Zhong YM. Exendin-4 promotes retinal ganglion cell survival and function by inhibiting calcium channels in experimental diabetes. iScience. 2023 Aug 18;26(9):107680. doi: 10.1016/j.isci.2023.107680. https://doi.org/10.1016/j.isci.2023.1076...
] |
Centruroides noxius
|
Noxiustoxin (II-11) |
Kv
|
4.19 |
|
|
390.00 |
|
[116116. Carbone E, Wanke E, Prestipino G, Possani LD, Maelicke A. Selective blockage of voltage-dependent K+ channels by a novel scorpion toxin. Nature. 1982 Mar 4;296(5852):90-1. doi: 10.1038/296090a0. https://doi.org/10.1038/296090a0...
] |
Centruroides noxius
|
Cobatoxin 1 |
Kv1.1 |
3.73 |
|
|
500.00 |
|
[5151. Selisko B, Garcia C, Becerril B, Gómez-Lagunas F, Garay C, Possani LD. Cobatoxins 1 and 2 from Centruroides noxius Hoffmann constitute a subfamily of potassium-channel-blocking scorpion toxins. Eur J Biochem. 1998 Jun 15;254(3):468-79. doi: 10.1046/j.1432-1327.1998.2540468.x. https://doi.org/10.1046/j.1432-1327.1998...
] |
Pandinus imperator
|
Pi1 |
Kv1.3 |
3.84 |
|
|
9.70 |
|
[117117. Péter Jr M, Varga Z, Panyi G, Bene L, Damjanovich S, Pieri C, Possani LD, Gáspár R Jr. Pandinus imperator scorpion venom blocks voltage-gated K+ channels in human lymphocytes. Biochem Biophys Res Commun. 1998 Jan 26;242(3):621-5. doi: 10.1006/bbrc.1997.8018. https://doi.org/10.1006/bbrc.1997.8018...
] |
Pandinus imperator
|
Pi2 |
Kv1.3 |
4.04 |
|
|
0.05 |
|
[117117. Péter Jr M, Varga Z, Panyi G, Bene L, Damjanovich S, Pieri C, Possani LD, Gáspár R Jr. Pandinus imperator scorpion venom blocks voltage-gated K+ channels in human lymphocytes. Biochem Biophys Res Commun. 1998 Jan 26;242(3):621-5. doi: 10.1006/bbrc.1997.8018. https://doi.org/10.1006/bbrc.1997.8018...
] |
Pandinus imperator
|
Pi3 |
Kv1.3 |
4.07 |
|
|
0.50 |
|
[117117. Péter Jr M, Varga Z, Panyi G, Bene L, Damjanovich S, Pieri C, Possani LD, Gáspár R Jr. Pandinus imperator scorpion venom blocks voltage-gated K+ channels in human lymphocytes. Biochem Biophys Res Commun. 1998 Jan 26;242(3):621-5. doi: 10.1006/bbrc.1997.8018. https://doi.org/10.1006/bbrc.1997.8018...
] |
Tityus cambridgei
|
Tc30 |
Kv1.3 |
3.87 |
|
|
15.90 |
|
[118118. Batista CV, Gómez-Lagunas F, Rodríguez de la Vega RC, Hajdu P, Panyi G, Gáspár R, Possani LD. Two novel toxins from the Amazonian scorpion Tityus cambridgei that block Kv1.3 and Shaker B K(+)-channels with distinctly different affinities. Biochim Biophys Acta. 2002 Dec 16;1601(2):123-31. doi: 10.1016/s1570-9639(02)00458-2. https://doi.org/10.1016/s1570-9639(02)00...
] |
Tityus cambridgei
|
Tc32 |
Kv1.3 |
3.52 |
|
|
9.90 |
|
[118118. Batista CV, Gómez-Lagunas F, Rodríguez de la Vega RC, Hajdu P, Panyi G, Gáspár R, Possani LD. Two novel toxins from the Amazonian scorpion Tityus cambridgei that block Kv1.3 and Shaker B K(+)-channels with distinctly different affinities. Biochim Biophys Acta. 2002 Dec 16;1601(2):123-31. doi: 10.1016/s1570-9639(02)00458-2. https://doi.org/10.1016/s1570-9639(02)00...
] |
Anuroctonus phaiodactylus
|
Anuroctoxin |
Kv1.3 |
4.08 |
|
|
0.73 |
|
[119119. Bagdáany M, Batista CVF, Valdez-Cruz NA, Somodi S, de la Vega RCR, Licea AF, et al. Anuroctoxin, a New Scorpion Toxin of the α-KTx 6 Subfamily, Is Highly Selective for Kv1.3 over IKCa1 Ion Channels of Human T Lymphocytes. Mol Pharmacol. 2005;67:1034-44.] |
Tityus serrulatus
|
Ts19 Frag-II |
Kv1.2 |
5.53 |
|
|
544.00 |
|
[120120. Cerni FA, Pucca MB, Amorim FG, de Castro Figueiredo Bordon K, Echterbille J, Quinton L, De Pauw E, Peigneur S, Tytgat J, Arantes EC. Isolation and characterization of Ts19 Fragment II, a new long-chain potassium channel toxin from Tityus serrulatus venom. Peptides. 2016 Jun;80:9-17. doi: 10.1016/j.peptides.2015.06.004. https://doi.org/10.1016/j.peptides.2015....
] |
Opisthacanthus cayaporum
|
OcyKTx2 |
Kv1.3 |
3.81 |
|
|
18.00 |
|
[121121. Schwartz EF, Bartok A, Schwartz CA, Papp F, Gómez-Lagunas F, Panyi G, Possani LD. OcyKTx2, a new K⁺-channel toxin characterized from the venom of the scorpion Opisthacanthus cayaporum. Peptides. 2013 Aug;46:40-6. doi: 10.1016/j.peptides.2013.04.021. https://doi.org/10.1016/j.peptides.2013....
] |
Rhopalurus garridoi
|
ɑ-KTx 2.14 |
Kv1.1 |
3.94 |
|
|
1,000.00 |
|
[122122. Rodríguez-Ravelo R, Restano-Cassulini R, Zamudio FZ, Coronas FI, Espinosa-López G, Possani LD. A K⁺ channel blocking peptide from the Cuban scorpion Rhopalurus garridoi. Peptides. 2014 Mar;53:42-7. doi: 10.1016/j.peptides.2013.10.010 https://doi.org/10.1016/j.peptides.2013....
] |
Tityus stigmurus
|
TstβKTx |
Kv1.1 |
6.72 |
|
|
96.00 |
|
[123123. Diego-García E, Abdel-Mottaleb Y, Schwartz EF, de la Vega RC, Tytgat J, Possani LD. Cytolytic and K+ channel blocking activities of beta-KTx and scorpine-like peptides purified from scorpion venoms. Cell Mol Life Sci. 2008 Jan;65(1):187-200. doi: 10.1007/s00018-007-7370-x https://doi.org/10.1007/s00018-007-7370-...
] |
Centruroides margaritatus
|
Cm38 |
Kv1.2 |
2.82 |
|
|
0.96 |
|
[125125. Naseem MU, Carcamo-Noriega E, Beltrán-Vidal J, Borrego J, Szanto TG, Zamudio FZ, Delgado-Prudencio G, Possani LD, Panyi G. Cm28, a scorpion toxin having a unique primary structure, inhibits KV1.2 and KV1.3 with high affinity. J Gen Physiol. 2022 Aug 1;154(8):e202213146. doi: 10.1085/jgp.202213146 https://doi.org/10.1085/jgp.202213146...
] |
Centruroides margaritatus
|
Cm38 |
Kv1.3 |
2.82 |
|
|
1.30 |
|
[125125. Naseem MU, Carcamo-Noriega E, Beltrán-Vidal J, Borrego J, Szanto TG, Zamudio FZ, Delgado-Prudencio G, Possani LD, Panyi G. Cm28, a scorpion toxin having a unique primary structure, inhibits KV1.2 and KV1.3 with high affinity. J Gen Physiol. 2022 Aug 1;154(8):e202213146. doi: 10.1085/jgp.202213146 https://doi.org/10.1085/jgp.202213146...
] |
Centruroides margaritatus
|
Cm39 |
Kv1.2 |
3.98 |
|
|
65.00 |
|
[124124. Naseem MU, Gurrola-Briones G, Romero-Imbachi MR, Borrego J, Carcamo-Noriega E, Beltrán-Vidal J, Zamudio FZ, Shakeel K, Possani LD, Panyi G. Characterization and Chemical Synthesis of Cm39 (α-KTx 4.8): A Scorpion Toxin That Inhibits Voltage-Gated K+ Channel KV1.2 and Small- and Intermediate-Conductance Ca2+-Activated K+ Channels KCa2.2 and KCa3.1. Toxins (Basel) . 2023 Jan 5;15(1):41. doi: 10.3390/toxins15010041 https://doi.org/10.3390/toxins15010041...
] |
Centruroides margaritatus
|
CmERG1 |
Kv11.1 |
4.79 |
|
|
3.40 |
|
[101101. Beltrán-Vidal J, Carcamo-Noriega E, Pastor N, Zamudio-Zuñiga F, Guerrero-Vargas JA, Castaño S, Possani LD, Restano-Cassulini R. Colombian Scorpion Centruroides margaritatus: Purification and Characterization of a Gamma Potassium Toxin with Full-Block Activity on the hERG1 Channel. Toxins (Basel). 2021 Jun 8;13(6):407. doi: 10.3390/toxins13060407. https://doi.org/10.3390/toxins13060407...
] |
Centruroides elegans elegans
|
CeERG4 |
Kv11.1 |
4.76 |
|
|
12.80 |
|
[127127. Restano-Cassulini R, Olamendi-Portugal T, Zamudio F, Becerril B, Possani LD. Two novel ergtoxins, blockers of K+-channels, purified from the Mexican scorpion Centruroides elegans elegans. Neurochem Res. 2008 Aug;33(8):1525-33. doi: 10.1007/s11064-008-9634-8 https://doi.org/10.1007/s11064-008-9634-...
] |
Tityus discrepans
|
Discrepin |
Kv4.3 |
4.17 |
|
|
190.00 |
|
[129129. D’Suze G, Batista CV, Frau A, Murgia AR, Zamudio FZ, Sevcik C, Possani LD, Prestipino G. Discrepin, a new peptide of the sub-family alpha-ktx15, isolated from the scorpion Tityus discrepans irreversibly blocks K+ -channels (IA currents) of cerebellum granular cells. Arch Biochem Biophys. 2004 Oct 15;430(2):256-63. doi: 10.1016/j.abb.2004.07.010 https://doi.org/10.1016/j.abb.2004.07.01...
] |
Phoneutria nigriventer
|
Tx3-2 |
ICaL
|
3.55 |
|
|
|
280.00*
|
[145145. Kalapothakis E, Penaforte CL, Leão RM, Cruz JS, Prado VF, Cordeiro MN, Diniz CR, Romano-Silva MA, Prado MA, Gomez MV, Beirão PS. Cloning, cDNA sequence analysis and patch clamp studies of a toxin from the venom of the armed spider (Phoneutria nigriventer). Toxicon. 1998 Dec;36(12):1971-80. doi: 10.1016/s0041-0101(98)00127-5 . https://doi.org/10.1016/s0041-0101(98)00...
] |
Grammostola spatulata
|
Grammotoxin |
iICaP
|
4.10 |
|
|
|
50.00*
|
[136136. McDonough SI, Lampe RA, Keith RA, Bean BP. Voltage-dependent inhibition of N- and P-type calcium channels by the peptide toxin omega-grammotoxin-SIA. Mol Pharmacol. 1997 Dec;52(6):1095-104. doi: 10.1124/mol.52.6.1095 https://doi.org/10.1124/mol.52.6.1095...
] |
Grammostola iheringi
|
GiTx1 |
Kv4.3 |
3.58 |
|
|
|
2,000.00*
|
[5050. Montandon GG, Cassoli JS, Peigneur S, Verano-Braga T, Santos DMD, Paiva ALB, Moraes ÉR, Kushmerick C, Borges MH, Richardson M, et al. GiTx1(β/κ-theraphotoxin-Gi1a), a novel toxin from the venom of Brazilian tarantula Grammostola iheringi (Mygalomorphae, Theraphosidae): Isolation, structural assessments and activity on voltage-gated ion channels. Biochimie. 2020 Sep;176:138-149. doi: 10.1016/j.biochi.2020.07.008. https://doi.org/10.1016/j.biochi.2020.07...
] |
Grammostola iheringi
|
GiTx1 |
Kv11.1 |
3.58 |
|
|
|
3,695.00 |
[5050. Montandon GG, Cassoli JS, Peigneur S, Verano-Braga T, Santos DMD, Paiva ALB, Moraes ÉR, Kushmerick C, Borges MH, Richardson M, et al. GiTx1(β/κ-theraphotoxin-Gi1a), a novel toxin from the venom of Brazilian tarantula Grammostola iheringi (Mygalomorphae, Theraphosidae): Isolation, structural assessments and activity on voltage-gated ion channels. Biochimie. 2020 Sep;176:138-149. doi: 10.1016/j.biochi.2020.07.008. https://doi.org/10.1016/j.biochi.2020.07...
] |
Phrixotrichus auratus
|
PaTx1 |
Kv4.3 |
3.55 |
|
|
|
28.00 |
[140140. Diochot S, Drici MD, Moinier D, Fink M, Lazdunski M. Effects of phrixotoxins on the Kv4 family of potassium channels and implications for the role of Ito1 in cardiac electrogenesis. Br J Pharmacol . 1999 Jan;126(1):251-63. doi: 10.1038/sj.bjp.0702283 https://doi.org/10.1038/sj.bjp.0702283...
] |
Phrixotrichus auratus
|
PaTx2 |
Kv4.3 |
3.92 |
|
|
|
71.00 |
[140140. Diochot S, Drici MD, Moinier D, Fink M, Lazdunski M. Effects of phrixotoxins on the Kv4 family of potassium channels and implications for the role of Ito1 in cardiac electrogenesis. Br J Pharmacol . 1999 Jan;126(1):251-63. doi: 10.1038/sj.bjp.0702283 https://doi.org/10.1038/sj.bjp.0702283...
] |
Phrixotrichus auratus
|
PaTx1 |
Kv4.2 |
3.55 |
|
|
|
5.00 |
[140140. Diochot S, Drici MD, Moinier D, Fink M, Lazdunski M. Effects of phrixotoxins on the Kv4 family of potassium channels and implications for the role of Ito1 in cardiac electrogenesis. Br J Pharmacol . 1999 Jan;126(1):251-63. doi: 10.1038/sj.bjp.0702283 https://doi.org/10.1038/sj.bjp.0702283...
] |
Phrixotrichus auratus
|
PaTx2 |
Kv4.2 |
3.92 |
|
|
|
34.00 |
[140140. Diochot S, Drici MD, Moinier D, Fink M, Lazdunski M. Effects of phrixotoxins on the Kv4 family of potassium channels and implications for the role of Ito1 in cardiac electrogenesis. Br J Pharmacol . 1999 Jan;126(1):251-63. doi: 10.1038/sj.bjp.0702283 https://doi.org/10.1038/sj.bjp.0702283...
] |