LIU et al, 2015 2727 Liu HQ, Wang YH, Wang LL, Hao M. P16INK4A and survivin: Diagnostic and prognostic markers in cervical intraepithelial neoplasia and cervical squamous cell carcinoma. Exp Mol Pathol. 2015;99(1):44-9. DOI:10.1016/j.yexmp.2015.04.004 https://doi.org/10.1016/j.yexmp.2015.04....
|
380 |
Normal/CIN 1,2,3 and SCC |
p16 positively correlated with the grade of cervical diseases. |
MILLS et al,2015 2222 Mills AM, Paquette C, Castle PE, Stoler MH. Risk stratification by p16 immunostaining of CIN1 biopsies: a retrospective study of patients from the quadrivalent HPV vaccine trials. Am J Surg Pathol. 2015;39(5):611-7. DOI:10.1097/PAS.0000000000000374 https://doi.org/10.1097/PAS.000000000000...
|
524 |
CIN 1,2,3 |
p16 should only be used selectively for problematic scenarios, such as CIN2. |
KRISHNAPPA et al, 2014 1111 Krishnappa P, Mohamad IB, Lin YJ, Barua A. Expression of P16 in high- risk human papillomavirus related lesions of the uterine cervix in a government hospital, Malaysia. Diagn Pathol. 2014;9:202. DOI:10.1186/s13000-014-0202-z https://doi.org/10.1186/s13000-014-0202-...
|
75 |
Cervicitis / in situ carcinoma |
p16 may be useful to diagnose between the low- and high-grade cervix lesions. |
ZHANG et al, 2015 2323 Zhang G, Yang B, Abdul-Karim, FW. p16 Immunohistochemistry is Useful in Confirming High-grade Squamous Intraepithelial Lesions (HSIL) in Women with Negative HPV Testing. Int J Gynecol Pathol. 2015;34(2):180-6. DOI:10.1097/PGP.0000000000000112 https://doi.org/10.1097/PGP.000000000000...
|
46 |
Cervices Negative for high risk HPV |
p16 may be a useful biomarker for CIN2-3 |
GUSTINUCCI et al, 2012 2424 Gustinucci D, Passamonti B, Cesarini E, Butera D, Palmieri EA, Bulletti S, et al. Role of p16(INK4a) cytology testing as an adjunct to enhance the diagnostic specificity and accuracy in human papillomavirus-positive women within an organized cervical cancer screening program. Acta Cytol. 2012;56(5):506-14. DOI:10.1159/000338979 https://doi.org/10.1159/000338979...
|
578 |
cythology with |
p16 can be considered as a good biomarker |
GENOVÉS et al, 2014 1313 Genovés J, Alameda F, Mancebo G, Solé JM, Bellozillo B, Lloveras B, et al. Human papillomavirus detection and p16INK4a expression in cervical lesions: a comparative study. Hum Pathol. 2014;45(4):826-33. DOI:10.1016/j.humpath.2013.10.035 https://doi.org/10.1016/j.humpath.2013.1...
|
86 |
CIN1,2,3 |
Negative p16 in cervical dysplasia does not always imply regression of the lesion |
RAZMPOOSH et al, 2014 2121 Razmpoosh M, Sansregret A, Oligny LL, Patey N, Dormoy-Raclet V, Ducruet T, et al. Assessment of Correlation Between p16INK4a Staining, Specific Subtype of Human Papillomavirus, and Progression of LSIL/CIN1 Lesions: First Comparative Study. Am J Clin Pathol. 2014;142(1):104-10. DOI:10.1309/AJCPBX74QXCPXIKK https://doi.org/10.1309/AJCPBX74QXCPXIKK...
|
64 |
CIN 1 |
P16 may be useful as prognostic biomarker for CIN1 |
PACCHIARIOTTI et al, 2013 1414 Pacchiariotti A, Ferrari F, Bellardini P, Chini F, Collina G, Palma DP, et al. Prognostic value of p16-INK4A protein in women with negative or CIN1 histology result: A follow-up study. Int. J. Cancer, 2014;134(4): 897-904. DOI:10.1002/ijc.28407 https://doi.org/10.1002/ijc.28407...
|
369 |
CIN 1 |
P16 may be useful as prognostic biomarker for CIN1 (with restrict utilization) |
NICOL et al, 2012 2626 Leite PMO, Tafuri L, Costa MZO, Lima MIM, Simões RT. Evaluation of the p16 and Ki-67 Biomarkers as Predictors of the Recurrence of Premalignant Cervical Cancer Lesions after LEEP Conization. Rev Bras Ginecol Obstet. 2017;39(6):288-93. DOI:10.1055/s-0037-1598643 https://doi.org/10.1055/s-0037-1598643...
|
326 |
CIN 2-3/tumor HIV+ and HIV - |
P16 may be useful for CIN2-3 and tumor in well-defined situations |
AMARO-FILHO et al, 2013 99 Amaro-Filho SM, Golub JE, Nuovo GJ, Cunha CB, Levi JE, Villa LL, et al. A comparative analysis of clinical and molecular factors with the stage of cervical cancer in a Brazilian cohort. PLoS One. 2013;8(3):e57810. DOI:10.1371/journal.pone.0057810 https://doi.org/10.1371/journal.pone.005...
|
130 |
TMA with cervicitis/normal cervix, CIN 2-3 and tumor |
p16 was more expressed in advanced FIGO stages |