Schistosoma mansoni: structural damage after treatment with oxamniquineAbstract
The effects of a single dose (100 mg/kg-body weight of mouse) of oxamniquine on the worm's tegument and paranchyma in relation to the process of immunological granulomatous reaction of the host's liver are described under light and electron microscopy (EM). The lesions caused by the drug are sequentially and simultaneously described in form of swelling, surface bulble and disruption with erosions. Ulceration in the tubercules with loss of spines is often more extensive and severe in male worms and concentration of host's mononuclear cells is observed. The possible role of host's immune response is discussed.
Schistosoma mansoni: structural damage after treatment with oxamniquine
Ageu Magalhães Filho1
Maria Eliane Bezerra de Melo1
Paulo Antônio Padovan2
Isairas Pereira Padovan2
FIOCRUZ, Centro de Pesquisas Aggeu Magalhães, Recife, Brasil
UFPE, Laboratório de Imunopatologia, Recife, Brasil
The effects of a single dose (100 mg/kg-body weight of mouse) of oxamniquine on the worm's tegument and paranchyma in relation to the process of immunological granulomatous reaction of the host's liver are described under light and electron microscopy (EM). The lesions caused by the drug are sequentially and simultaneously described in form of swelling, surface bulble and disruption with erosions. Ulceration in the tubercules with loss of spines is often more extensive and severe in male worms and concentration of host's mononuclear cells is observed. The possible role of host's immune response is discussed.
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Publication Dates
-
Publication in this collection
26 June 2009 -
Date of issue
1987
