Gene ID |
Gene name |
Functional group |
Up/Down |
Function |
Possible pathogen association |
Reference |
AAEL000693 |
TOR |
Autophagy |
Up |
Inhibits autophagy, promoting cell growth |
Inhibition should prevent viral replication |
3131. Shertz CA, Cardenas ME. Exploiting and subverting tor signaling in the pathogenesis of fungi, parasites, and viruses. PLoS Pathog. 2011; 7(9): 8-10.
|
AAEL003712 |
C-type Lysozyme |
Immunity |
Up |
Involved in innate immunity specifically in AMP expression |
Lysozyme exerts a significant inhibitory effect on DENV |
2323. Ramirez JL, Souza-Neto J, Cosme RT, Rovira J, Ortiz A, Pascale JM, et al. Reciprocal tripartite interactions between the Aedes aegypti midgut microbiota, innate immune system and dengue virus influences vector competence. PLoS Negl Trop Dis. 2012; 6(3): 1-11.
|
AAEL002360 |
Serine-type endopeptidase |
Digestion |
Up |
Digestive enzymes which assists in breaking down meals |
Proteolytic activity of serine-type endopeptidases limits virus infectivity |
2424. Brackney DE, Foy BD, Olson KE. The effects of midgut serine proteases on dengue virus type 2 infectivity of Aedes aegypti. Am J Trop Med Hyg. 2008; 79(2): 267-74.
|
AAEL005444 |
Pyrokinin |
Digestion and ionic balance |
Up |
Neuropeptide that regulates growth, metamorphosis, plays a role in anti-diuresis |
Inhibits substrate absorption by anterior midgut |
3232. Paluzzi JP, O'Donnell MJ. Identification, spatial expression analysis and functional characterization of a pyrokinin-1 receptor in the Chagas' disease vector, Rhodnius prolixus. Mol Cell Endocrinol. 2012; 363(1-2): 36-45. encodes a pyrokinin-related peptide (known as pyrokinin-1), PK1 |
AAEL002992 |
Sphingolipid delta 4 desaturase |
Cell signaling |
Up |
Control cell proliferation, differentiation, and apoptosis |
|
3333. Ternes P, Franke S, Zähringer U, Sperling P, Heinz E. Identification and characterization of a sphingolipid ?4-desaturase family. J Biol Chem. 2002; 277(28): 25512-8.
|
AAEL005641 |
C-type lectin |
Binding |
Up |
Directly involved in cell galactose binding |
Primary candidates for PRRs |
3434. Cheng J, Wang Y, Li F, Liu J, Sun Y, Wu J. Cloning and characterization of a mannose binding C-type lectin gene from salivary gland of Aedes albopictus. Parasit Vectors. 2014; 7(1): 337.
|
AAEL001769 |
RM62B (dead box ATP-dependent RNA helicase) |
Immunity |
Up |
Guides the silencing of target transcripts within small RNA pathway |
Small RNA pathway (PIWI) may limit DENV replication |
3535. Hussain M, Asgari S. MicroRNA-like viral small RNA from dengue virus 2 autoregulates its replication in mosquito cells. Proc Natl Acad Sci USA. 2014; 111(7): 2746-51.
|
AAEL010195 |
Trypsin |
Digestion |
Up |
Digestive enzyme which assists in breaking down meals |
Higher trypsin expression results in higher DENV titers |
2525. Molina-Cruz A, Gupta L, Richardson J, Bennett K, Black IVW, Barillas-Mury C. Effect of mosquito midgut trypsin activity on dengue-2 virus infection and dissemination in Aedes aegypti. Am J Trop Med Hyg. 2005; 72(5): 631-7.
|
AAEL013063 |
Autophagy related gene |
Autophagy |
Up |
Participates in autophagy, an intracellular degradation system initiated upon stress |
Autophagy plays a supportive role in DENV replication |
2727. Lee HK, Iwasaki A. Autophagy and antiviral immunity. Curr Opin Immunol. 2008; 20(1): 23-9.,3636. Heaton NS, Randall G. Dengue virus-induced autophagy regulates lipid metabolism. Cell Host Microbe. 2010; 8(5): 422-32.,3737. Lee Y-R, Hu H-Y, Kuo S-H, Lei H-Y, Lin Y-S, Yeh T-M, et al. Dengue virus infection induces autophagy: an in vivo study. J Biomed Sci. 2013; 20(1): 65.
|
AAEL002083 |
RM62C (dead box ATP-dependent RNA helicase) |
Immunity |
Up |
Guides the silencing of target transcripts within small RNA pathway |
Small RNA pathway may limit DENV replication |
3535. Hussain M, Asgari S. MicroRNA-like viral small RNA from dengue virus 2 autoregulates its replication in mosquito cells. Proc Natl Acad Sci USA. 2014; 111(7): 2746-51.
|
AAEL000028 |
CLIPB34 |
Immunity |
Down |
Serine protease involved in immune and developmental processes |
Malaria parasites utilize CLIPs to sever surface proteins |
3838. Clements AN. The biology of mosquitoes: transmission of viruses and interactions with bacteria. Vol. 3. Oxfordshire: CABI; 2012.
|
AAEL014222 |
Low-density lipoprotein |
Cell transport |
Down |
Mediates receptor endocytosis |
A wide variety of viruses utilize LDLs to enter host cells |
3939. van Gorp EC, Suharti C, Mairuhu AT, Dolmans WM, van Der Ven J, Demacker PN, et al. Changes in the plasma lipid profile as a potential predictor of clinical outcome in dengue hemorrhagic fever. Clin Infect Dis. 2002; 34(8): 1150-3.
|
AAEL008083 |
40S ribosomal protein |
Cell growth and proliferation |
Down |
Directly involved in protein translation |
Putative receptor for the entry of DENV into host cells |
2626. Guo X, Xu Y, Bian G, Pike AD, Xie Y, Xi Z. Response of the mosquito protein interaction network to dengue infection. BMC Genomics. 2010; 11(1): 1-15.
|
AAEL009888 |
Bumetanide-sensitive Na-K-Cl cotransport |
Transport |
Down |
Vital role in regulating ionic balance and cell volume |
|
4040. Gillen C, Akuma D, Piermarini P. Expression pattern and RNAi inhibition of putative sodium-coupled cation-chloride cotransporters in the mosquito Aedes aegypti. Faseb J. 2015; 29(Suppl. 1).
|
AAEL004978 |
RM62E (dead box ATP-dependent RNA helicase) |
Immunity |
Down |
Guides the silencing of target transcripts within small RNA pathway |
Small RNA pathway may limit DENV replication |
3535. Hussain M, Asgari S. MicroRNA-like viral small RNA from dengue virus 2 autoregulates its replication in mosquito cells. Proc Natl Acad Sci USA. 2014; 111(7): 2746-51.
|