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• Mem. Inst. Oswaldo Cruz 90 (2) • Apr 1995 • https://doi.org/10.1590/S0074-02761995000200022 linkcopy

Open-access Vaccination against schistosomiasis and fascioliasis with the new recombinant antigen Sm14: potential basis of a multi-valent anti-helminth vaccine?

AuthorshipSCIMAGO INSTITUTIONS RANKINGS

    Abstract

    Molecular cloning of components of protective antigenic preparations have suggested that related parasite fatty acid binding proteins could form the basis of the well documented protective, immune cross reactivity between the parasitic trematode worms Fasciola hepatica and Schistosoma mansoni. We have now confirmed the cross protective potential of parasite fatty acid binding proteins and suggest that it may be possible to produce a single vaccine that would be effective against at least two parasites, F. hepatica and S. mansoni of veterinary and human importance respectively.

    schistosomiasis; fascioliasis; vaccines; fatty acid binding protein (FABP)

    ABSTRACT

    Vaccination against schistosomiasis and fascioliasis with the new recombinant antigen Sm14: potential basis of a multi-valent anti-helminth vaccine?

    Miriam Tendler1

    Monica Magno Vilar1

    Cristiana Alves Brito2

    Nicolau Maués da Serra Freire3

    Naftale Katz4

    Andrew Simpson5

    Instituto Oswaldo Cruz, Departamento de Helmintologia, Laboratõrio de Esquistossomose Experimental, Rio de Janeiro, Brasil

    FIOCRUZ, Centro de Pesquisas René Rachou, Laboratório de Biologia Moelecular, Rio de Janeiro, Brasil

    Universidade Federal Rural do Rio de Janeiro, Brasil

    FIOCRUZ, Centro de Pesquisas René Rachou, Laboratório de Biologia Molecular, Rio de Janeiro, Brasil

    FIOCRUZ, Centro de Pesquisas René Rachou, Laboratório de Biologia Molecular, Belo Horizonte, Brasil

    Molecular cloning of components of protective antigenic preparations have suggested that related parasite fatty acid binding proteins could form the basis of the well documented protective, immune cross reactivity between the parasitic trematode worms Fasciola hepatica and Schistosoma mansoni. We have now confirmed the cross protective potential of parasite fatty acid binding proteins and suggest that it may be possible to produce a single vaccine that would be effective against at least two parasites, F. hepatica and S. mansoni of veterinary and human importance respectively.

    Full text available only in PDF format.

    Texto completo disponível apenas em PDF.

    Publication Dates

    • Publication in this collection
      01 June 2009
    • Date of issue
      Apr 1995
    Creative Common - by-nc 4.0
    This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
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    Instituto Oswaldo Cruz, Ministério da Saúde Av. Brasil, 4365 - Pavilhão Mourisco, Manguinhos, 21040-900 Rio de Janeiro RJ Brazil, Tel.: (55 21) 2562-1222, Fax: (55 21) 2562 1220 - Rio de Janeiro - RJ - Brazil
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