CCBH-2020 |
PAO1-2020 |
Gene |
Total number of connections (k-out) |
Function |
Gene |
Total number of connections (k-out) |
rpoD
|
740 |
Control of expression of housekeeping genes7070. Aramaki H, Fujita M. In vitro transcription analysis of rpoD in Pseudomonas aeruginosa PAO1. FEMS Microbiol Lett. 1999; 180(2): 311-6. |
rpoD
|
749 |
rpoN
|
650 |
Nitrogen metabolism, adhesion, quorum sensing (QS), biofilm formation7171. Caiazza NC, O'Toole GA. SadB is required for the transition from reversible to irreversible attachment during biofilm formation by Pseudomonas aeruginosa PA14. J Bacteriol. 2004; 186(14): 4476-85. |
rpoN
|
658 |
algU
|
353 |
Positive regulation of response to oxidative stress7272. Martin DW, Schurr MJ, Yu H, Deretic V. Analysis of promoters controlled by the putative sigma factor AlgU regulating conversion to mucoidy in Pseudomonas aeruginosa: relationship to sigma E and stress response. J Bacteriol. 1994; 176(21): 6688-96. |
algU
|
357 |
sigX
|
298 |
Positive regulation of cell growth7373. Brinkman FS, Schoofs G, Hancock RE, De Mot R. Influence of a putative ECF sigma factor on expression of the major outer membrane protein, OprF, in Pseudomonas aeruginosa and Pseudomonas fluorescens. J Bacteriol. 1999; 181(16): 4746-54. |
sigX
|
319 |
rpoS
|
278 |
QS, Biofilm, virulence, antibiotic resistance7474. Fujita M, Tanaka K, Takahashi H, Amemura A. Transcription of the principal sigma-factor genes, rpoD and rpoS, in Pseudomonas aeruginosa is controlled according to the growth phase. Mol Microbiol. 1994; 13(6): 1071-7. |
fliA
|
281 |
fliA
|
270 |
Adhesion, flagellin biosynthesis7575. Starnbach MN, Lory S. The fliA (rpoF) gene of Pseudomonas aeruginosa encodes an alternative sigma factor required for flagellin synthesis. Mol Microbiol. 1992; 6(4): 459-69. |
rpoS
|
271 |
rpoH
|
184 |
Heat-shock response7676. Benvenisti L, Koby S, Rutman A, Giladi H, Yura T, Oppenheim AB. Cloning and primary sequence of the rpoH gene from Pseudomonas aeruginosa. Gene. 1995; 155(1): 73-6. |
rpoH
|
194 |
gacA
|
121 |
Monolayer and biofilm formation7777. Parkins MD, Ceri H, Storey DG. Pseudomonas aeruginosa GacA, a factor in multihost virulence, is also essential for biofilm formation. Mol Microbiol. 2001; 40(5): 1215-26. |
gacA
|
128 |
algR
|
119 |
Cell motility, biofilm formation7878. Lizewski SE, Lundberg DS, Schurr MJ. The transcriptional regulator AlgR is essential for Pseudomonas aeruginosa pathogenesis. Infect Immun. 2002; 70(11): 6083-93. |
algR
|
122 |
amrZ
|
109 |
Cell motility, biofilm formation7979. Waligora EA, Ramsey DM, Pryor Jr EE, Lu H, Hollis T, Sloan GP, et al. AmrZ beta-sheet residues are essential for DNA binding and transcriptional control of Pseudomonas aeruginosa virulence genes. J Bacteriol. 2010; 192(20): 5390-401. |
amrZ
|
115 |
lasR
|
106 |
QS, regulation of elastin catabolic process8080. Gambello MJ, Iglewski BH. Cloning and characterization of the Pseudomonas aeruginosa lasR gene, a transcriptional activator of elastase expression. J Bacteriol. 1991; 173(9): 3000-9. |
lasR
|
95 |
fleQ
|
92 |
Regulation of mucin adhesion and flagellar expression8181. Arora SK, Ritchings BW, Almira EC, Lory S, Ramphal R. A transcriptional activator, FleQ, regulates mucin adhesion and flagellar gene expression in Pseudomonas aeruginosa in a cascade manner. J Bacteriol. 1997; 179(17): 5574-81. |
pvdS
|
91 |
fur
|
88 |
Control of expression of siderophores and exotoxin A8282. Barton HA, Johnson Z, Cox CD, Vasil AI, Vasil ML. Ferric uptake regulator mutants of Pseudomonas aeruginosa with distinct alterations in the iron-dependent repression of exotoxin A and siderophores in aerobic and microaerobic environments. Mol Microbiol. 1996; 21(5): 1001-17. |
sphR
|
90 |
pvdS
|
87 |
Iron metabolism, pyoverdine, virulence8383. Cunliffe HE, Merriman TR, Lamont IL. Cloning and characterization of pvdS, a gene required for pyoverdine synthesis in Pseudomonas aeruginosa: PvdS is probably an alternative sigma factor. J Bacteriol. 1995; 177(10): 2744-50.,8484. Beare PA, For RJ, Martin LW, Lamont IL. Siderophore-mediated cell signalling in Pseudomonas aeruginosa: divergent pathways regulate virulence factor production and siderophore receptor synthesis. Mol Microbiol. 2003; 47(1): 195-207. |
fleQ
|
85 |
sphR
|
74 |
Sphingosine catabolic process8585. LaBauve AE, Wargo MJ. Detection of host-derived sphingosine by Pseudomonas aeruginosa is important for survival in the murine lung. PLoS Pathog. 2014; 10(1): e1003889. |
fur
|
69 |
mvfR
|
65 |
QS, regulation of lyase activity, control production of virulence factors8686. Déziel E, Gopalan S, Tampakaki AP, Lépine F, Padfield KE, Saucier M, et al. The contribution of MvfR to Pseudomonas aeruginosa pathogenesis and quorum sensing circuitry regulation: multiple quorum sensing-regulated genes are modulated without affecting lasRI, rhlRI or the production of N-acyl-L-homoserine lactones. Mol Microbiol. 2005; 55(4): 998-1014. |
vqsM
|
65 |
vqsM
|
61 |
QS, control production of virulence factors8787. Liang H, Deng X, Li X, Ye Y, Wu M. Molecular mechanisms of master regulator VqsM mediating quorum-sensing and antibiotic resistance in Pseudomonas aeruginosa. Nucleic Acids Res. 2014; 42(16): 10307-20. |
mvfR
|
62 |
anr
|
58 |
Regulation of oxidoreductase activity8888. Rompf A, Hungerer C, Hoffmann T, Lindenmeyer M, Römling U, Gross U, et al. Regulation of Pseudomonas aeruginosa hemF and hemN by the dual action of the redox response regulators Anr and Dnr. Mol Microbiol. 1998; 29(4): 985-97. |
pchR
|
57 |
rhlR
|
56 |
QS, regulation of lipid biosynthetic and proteolysis8989. Ochsner UA, Koch AK, Fiechter A, Reiser J. Isolation and characterization of a regulatory gene affecting rhamnolipid biosurfactant synthesis in Pseudomonas aeruginosa. J Bacteriol. 1994; 176(7): 2044-54.,9090. Brint JM, Ohman DE. Synthesis of multiple exoproducts in Pseudomonas aeruginosa is under the control of RhlR-RhlI, another set of regulators in strain PAO1 with homology to the autoinducer-responsive LuxR-LuxI family. J Bacteriol. 1995; 177(24): 7155-63. |
anr
|
53 |
mexT
|
53 |
Antibiotic efflux pump9191. Köhler T, Epp SF, Curty LK, Pechère JC. Characterization of MexT, the regulator of the MexE-MexF-OprN multidrug efflux system of Pseudomonas aeruginosa. J Bacteriol. 1999; 181(20): 6300-5. |
mexT
|
51 |
pchR
|
47 |
Regulation of pyochelin siderophore, ferripyochelin receptor synthesis9292. Heinrichs DE, Poole K. Cloning and sequence analysis of a gene (pchR) encoding an AraC family activator of pyochelin and ferripyochelin receptor synthesis in Pseudomonas aeruginosa. J Bacteriol. 1993; 175(18): 5882-9. |
argR
|
46 |
argR
|
46 |
Controls arginine uptake and metabolism9393. Lu CD, Yang Z, Li W. Transcriptome analysis of the ArgR regulon in Pseudomonas aeruginosa. J Bacteriol. 2004; 186(12): 3855-61. |
fecI
|
44 |
gbdR
|
44 |
Regulation of cellular amino acid metabolic process9494. Wargo MJ, Ho TC, Gross MJ, Whittaker LA, Hogan DA. GbdR regulates Pseudomonas aeruginosa plcH and pchP transcription in response to choline catabolites. Infect Immun. 2009; 77(3): 1103-11. |
gbdR
|
42 |
pmrA
|
43 |
Antibiotic efflux pump9595. Piddock LJ, Johnson MM, Simjee S, Pumbwe L. Expression of efflux pump gene pmrA in fluoroquinolone-resistant and -susceptible clinical isolates of Streptococcus pneumoniae. Antimicrob Agents Chemother. 2002; 46(3): 808-12.,9696. McPhee JB, Lewenza S, Hancock RE. Cationic antimicrobial peptides activate a two-component regulatory system, PmrA-PmrB, that regulates resistance to polymyxin B and cationic antimicrobial peptides in Pseudomonas aeruginosa. Mol Microbiol. 2003; 50(1): 205-17. |
rhlR
|
40 |
fecI
|
41 |
Regulation of iron ion transport9797. Miyazaki H, Kato H, Nakazawa T, Tsuda M. A positive regulatory gene, pvdS, for expression of pyoverdin biosynthetic genes in Pseudomonas aeruginosa PAO. Mol Gen Genet. 1995; 248(1): 17-24. |
phoB
|
40 |
soxR
|
40 |
Antibiotic efflux pump9898. Palma M, Zurita J, Ferreras JA, Worgall S, Larone DH, Shi L, et al. Pseudomonas aeruginosa SoxR does not conform to the archetypal paradigm for SoxR-dependent regulation of the bacterial oxidative stress adaptive response. Infect Immun. 2005; 73(5): 2958-66. |
pmrA
|
40 |
phoB
|
40 |
Cell motility, regulation of cellular response to phosphate starvation9999. Faure LM, Llamas MA, Bastiaansen KC, de Bentzmann S, Bigot S. Phosphate starvation relayed by PhoB activates the expression of the Pseudomonas aeruginosa svreI ECF factor and its target genes. Microbiology (Reading). 2013; 159(Pt 7): 1315-27.,100100. Blus-Kadosh I, Zilka A, Yerushalmi G, Banin E. The effect of pstS and phoB on quorum sensing and swarming motility in Pseudomonas aeruginosa. PLoS One. 2013; 8(9): e74444. |
soxR
|
39 |
vfr
|
37 |
QS, exotoxin A regulator, cell motility101101. Beatson SA, Whitchurch CB, Sargent JL, Levesque RC, Mattick JS. Differential regulation of twitching motility and elastase production by Vfr in Pseudomonas aeruginosa. J Bacteriol. 2002; 184(13): 3605-13. |
dnr
|
34 |
dnr
|
34 |
Regulation of nitrogen compound metabolic process102102. Trunk K, Benkert B, Quäck N, Münch R, Scheer M, Garbe J, et al. Anaerobic adaptation in Pseudomonas aeruginosa: definition of the Anr and Dnr regulons. Environ Microbiol. 2010; 12(6): 1719-33. |
himA
|
30 |
rsaL
|
34 |
QS, biofilm formation, regulation of virulence factors103103. Rampioni G, Schuster M, Greenberg EP, Zennaro E, Leoni L. Contribution of the RsaL global regulator to Pseudomonas aeruginosa virulence and biofilm formation. FEMS Microbiol Lett. 2009; 301(2): 210-7. |
himD
|
30 |