|
Faria et al. (2009)Faria DR, Souza PE, Duraes FV, Carvalho EM, Gollob KJ, Machado PR, et al. Recruitment of CD8(+) T cells expressing granzyme A is associated with lesion progression in human cutaneous leishmaniasis. Parasite Immunol. 2009; 31(8): 432-9.
|
Lesion cells |
Leishmania braziliensis
|
CL |
Granzyme A |
Expression of granzyme A by CD8+ T cells is involved in tissue destruction. |
|
Santos et al. (2013)Santos CS, Boaventura V, Cardoso CR, Tavares N, Lordelo MJ, Noronha A, et al. CD8(+) granzyme B(+)-mediated tissue injury vs. CD4(+)IFNgamma(+)-mediated parasite killing in human cutaneous leishmaniasis. J Invest Dermatol. 2013; 133(6): 1533-40.
|
Ex-vivo/In-vitro: blood lesion cells |
L. braziliensis
|
CL |
Granzyme B CD107a |
Frequency of granzyme B+ correlates positively with lesion size; increased CD107a expression on CD8+ T cells upon infection. |
|
Dantas et al. (2013)Dantas ML, Oliveira JC, Carvalho L, Passos ST, Queiroz A, Machado P, et al. CD8+ T cells in situ in different clinical forms of human cutaneous leishmaniasis. Rev Soc Bras Med Trop. 2013; 46(6): 728-34.
|
In situ: lesion cells |
L. braziliensis
|
ECL, CL and DL |
Granzyme B |
ECL: positive correlation between granzyme B+ cells and inflammatory infiltrate in lesions. |
|
Novais et al. (2013)Novais FO, Carvalho LP, Graff JW, Beiting DP, Ruthel G, Roos DS, et al. Cytotoxic T cells mediate pathology and metastasis in cutaneous leishmaniasis. PLoS Pathog. 2013; 9(7): e1003504.
|
Ex-vivo lesion cells |
L. braziliensis
|
CL |
Granzyme B Perforin CD107a |
CD8+ T cells from lesions express more granzyme B, perforin and CD107a than CD8+ T cells from peripheral blood. |
|
Cardoso et al. (2015)Cardoso TM, Machado A, Costa DL, Carvalho LP, Queiroz A, Machado P, et al. Protective and pathological functions of CD8+ T Cells in Leishmania braziliensis infection. Infect Immun. 2015; 83(3): 898-906.
|
Ex-vivo/In-vitro: blood |
L. braziliensis
|
CL SC |
Granzyme B |
Granzyme B production in CD8+ T cells is higher in CL than in SC individuals. |
|
Novais et al. (2015)Novais FO, Carvalho LP, Passos S, Roos DS, Carvalho EM, Scott P, et al. Genomic profiling of human Leishmania braziliensis lesions identifies transcriptional modules associated with cutaneous immunopathology. J Invest Dermatol. 2015; 135(1): 94-101.
|
Lesion cells |
L. braziliensis
|
CL |
Granzyme B Perforin |
Transcripts associated the cytotoxicity and apoptosis (GZMB, PRF1, CASP3, CASP4, CASP5, CASP7 and BID). |
|
Ferraz et al. (2015)Ferraz R, Cunha CF, Gomes-Silva A, Schubach AO, Pimentel MI, Lyra MR, et al. Apoptosis and frequency of total and effector CD8+ T lymphocytes from cutaneous leishmaniasis patients during antimonial therapy. BMC Infect Dis. 2015; 19(15): 74.
|
Ex-vivo/In-vitro: blood |
L. braziliensis
|
CL-during treatment |
|
Positive correlation between frequency of apoptotic-effector CD8+ T cells and lesion size. |
|
Ferraz et al. (2017)Ferraz R, Cunha CF, Pimentel MIF, Lyra MR, Pereira-da-Silva T, Schubach AO, et al. CD3+CD4negCD8neg (double negative) T lymphocytes and NKT cells as the main cytotoxic-related-CD107a+ cells in lesions of cutaneous leishmaniasis caused by Leishmania (Viannia) braziliensis. Parasit Vectors. 2017; 10(1): 219.
|
Ex-vivo: blood |
L. braziliensis
|
CL |
CD107a |
NKT and double negative T cells are the main cell population of degranulating in CL lesions. |
