MHC region (class I-III) |
Cw7 |
SE Asian Hmong |
CL |
NA |
p = 0.01 |
Barbier et al. (1987) |
3478848 |
A28; Bw22 |
Venezuelan |
LCL |
24 families |
p = 0.0018; 0.0122 |
Lara et al. (1991) |
2022495 |
Bw22 |
Venezuelan |
LCL |
Ca = 26; Co = 26 |
RR = 12.5; p = 0.048 |
Lara et al. (1991) |
2022495 |
DQw8 |
Venezuelan |
LCL |
24 families |
p = 0.0364 |
Lara et al. (1991) |
2022495 |
DQw3 |
Venezuelan |
LCL |
Ca = 26; Co = 26 |
RR = 4.25; p = 0.036 |
Lara et al. (1991) |
2022495 |
DR2 |
Brazilian |
MCL |
Ca = 43; Co = 111 |
RR = 0.07; p = 0.004 |
Petzl-Erler et al. (1991) |
1783572 |
DQw3 |
Brazilian |
MCL |
Ca = 43; Co = 111 |
RR = 4.2; p = 0.006 |
Petzl-Erler et al. (1991) |
1783572 |
DR2; DR7/DRw9 |
Venezuelan |
CL |
Ca = 49; Co = 43 |
p < 0.05 |
Cabrera et al. (1995) |
7595196 |
LTA |
Venezuelan |
MCL |
Ca = 25; Co = 43 |
RR = 7.5; p < 0.001 |
Cabrera et al. (1995) |
7595196 |
TNF (-308) |
Venezuelan |
MCL |
Ca = 25; Co = 43 |
RR = 3.5; p < 0.05 |
Cabrera et al. (1995) |
7595196 |
DRB1*0407; DPA1*0401; DPB1*0101 |
Mexican mestizos |
LCL |
Ca = 65; Co = 100 |
OR = 2.92, 10.07, 5.99 |
Olivo-Diaz et al. (2004) |
15041165 |
DPB1*0401; DR2 |
Mexican mestizos |
LCL |
Ca = 65; Co = 100 |
OR = 0.38, 0.14 |
Olivo-Diaz et al. (2004) |
15041165 |
Non-MHC candidate genes |
|
|
|
|
|
IL6-174 |
Brazilian |
ML |
Ca = 60; Co = 180 |
OR = 2.29 (1.40-3.77); p = 0.001 |
Castellucci et al. (2006) |
16845637 |
IFNG+874 |
Iranian |
Chronic CL |
Ca = 58; Co = 688 |
χ2 = 12.53; p = 0.0019 |
Kamali-Sarvestani et al. (2006) |
16950634 |
IL-4-590 |
Iranian |
LCL |
Ca = 201; Co = 92 |
χ2 = 8.64; p = 0.003 |
Kamali-Sarvestani et al. (2006) |
16950634 |
IL-10-819 |
Brazilian |
CL |
30 families |
OR = 2.5 (1.12-5.7); p = 0.003 |
Salhi et al. (2008) |
18424735 |
CXCR1 rs2854386 |
Brazilian |
CL |
Ca = 60; Co = 60 |
OR = 2.38 (1.23-4.57); p = 0.009 |
Castellucci et al. (2010) |
20089160 |
CXCR1 rs2854386 |
Brazilian |
ML |
104 families |
p = 0.046 |
Castellucci et al. (2010) |
20089160 |
SLC11A1 rs17235416 |
Brazilian |
CL |
104 families |
p = 0.011 |
Castellucci et al. (2010) |
20089160 |
CCL2-2518 |
Brazilian |
ML |
Ca = 67; Co = 120 |
OR = 4.40 (1.42-13.65); p = 0.010 |
Ramasawmy et al. (2010) |
20430117 |
FLI1 rs7930515 |
Brazilian |
CL |
209 transmissions |
OR = 1.62 (1.26-2.09); p = 1.8 x 10-4
|
Castellucci et al. (2011) |
21633373 |
TLR4 Asp299Gly |
Iranian |
Chronic CL |
Ca = 22; Co = 75 |
OR = 25.3 (5.2-115.6); p < 0.001 |
Ajdary et al. (2011) |
21056683 |
TLR4 Asp299Gly |
Iranian |
Acute CL |
Ca = 61; Co = 75 |
OR = 8.03 (1.7-37.7); p = 0.006 |
Ajdary et al. (2011) |
21056683 |
TLR4 Thr399Ile |
Iranian |
Chronic CL |
Ca = 22; Co = 75 |
p < 0.001 |
Ajdary et al. (2011) |
21056683 |
TLR4 Thr399Ile |
Iranian |
Acute CL |
Ca = 61; Co = 75 |
p = 0.016 |
Ajdary et al. (2011) |
21056683 |
CTGF rs6918698 |
Brazilian |
CL |
271 transmissions |
OR = 1.67 (1.10-2.54); p = 0.016 |
Castellucci et al. (2012) |
22554650 |
FLII rs2071242 |
Brazilian |
CL |
268 transmissions |
OR = 1.60 (1.14-2.24); p = 0.005 |
Castellucci et al. (2012) |
22554650 |
TGFBR2 rs1962859 |
Brazilian |
CL |
295 transmissions |
OR = 1.50 (1.12-1.99); p = 0.005 |
Castellucci et al. (2012) |
22554650 |
SMAD2 rs1792658 |
Brazilian |
CL |
210 transmissions |
OR = 1.57 (1.04-2.38); p = 0.03 |
Castellucci et al. (2012) |
22554650 |
SMAD7 rs4464148 |
Brazilian |
CL |
278 transmissions |
OR = 2.80 (1.00-7.87); p = 0.05 |
Castellucci et al. (2012) |
22554650 |
SMAD3 rs1465841 |
Brazilian |
ML |
52 transmissions |
OR = 2.15 (1.13-4.07); p = 0.018 |
Castellucci et al. (2012) |
22554650 |
SMAD7 rs2337107 |
Brazilian |
ML |
50 transmissions |
OR = 3.70 (1.27-10.7); p = 0.016 |
Castellucci et al. (2012) |
22554650 |
IL-1β-511 |
Mexican mestizos |
LCL |
Ca = 58; Co = 123 |
OR = 3.23 (1.2-8.7); p = 0.0167 |
Fernández-Figueroa et al. (2012) |
22629474 |
MIF-173 |
Brazilian |
CL |
Ca = 110; Co = 682 |
OR = 1.79 (1.15-2.78); p = 0.008 |
Covas et al. (2013) |
23068083 |
Papers reporting no significant linkage or association
|
Candidate gene |
Population |
Phenotype |
Sample size |
Reported result |
Reference |
PMID |
|
MHC region (class I-III) |
TNF rs1800629 |
Sri Lankan |
CL |
Ca = 200; Co = 200 |
NS |
Samaranayake et al. (2010) |
20214763 |
LTA rs909253 |
Sri Lankan |
CL |
Ca = 200; Co = 200 |
NS |
Samaranayake et al. (2010) |
20214763 |
Non-MHC candidate genes |
|
|
|
|
|
IFNG+874 |
Brazilian |
CL |
Ca = 136; Co = 609 |
NS |
Matos et al. (2007) |
17456233 |
SLC11A1 rs2276631 |
Sri Lankan |
CL |
Ca = 200; Co = 200 |
NS |
Samaranayake et al. (2010) |
20214763 |
SLC11A1 rs3731865 |
Sri Lankan |
CL |
Ca = 200; Co = 200 |
NS |
Samaranayake et al. (2010) |
20214763 |
SLC11A1 rs17235409 |
Sri Lankan |
CL |
Ca = 200; Co = 200 |
NS |
Samaranayake et al. (2010) |
20214763 |
TLR2 Arg753Gln |
Iranian |
CL |
Ca = 84; Co = 120 |
NS |
Ajdary et al. (2010) |
20388552 |
TLR2 Arg677Trp |
Iranian |
CL |
Ca = 84; Co = 120 |
NS |
Ajdary et al. (2010) |
20388552 |
FcyRIIA-H/R131 |
Brazilian |
CL |
Ca = 88; Co = 98 |
NS |
Oliveira et al. (2011) |
21324097 |