Al Kubaisi & Alousi, Iraq [3030 Al-Kubaisi AHMA, Al-Alouse WS. Dental caries experience among patients with congenital coagulation disorders. J Fac Medd Baghdad Jol 2006; 48(1):17-20.] |
Comparative Cross-Section |
Total: [5-42] |
Total: 314
Hemophilia A and B and Congenital Coagulation Disorders: 157
Control: 157
|
Case: Al-Mansour Hospital for children in Baghdad City Control: NR |
Dental Caries (DMFS/dmfs) |
97.8% |
91.9% |
Baskirt et al., Turkey [7] |
Comparative Cross-Section |
Total: [6-12]
Case: 9.54±2.39
Control: 9.49±1.70
|
Total: 111
Case: Hemophilia A: 36 (Hemophilia Severity: Mild, 14; Moderate, 12; Severe, 10) Control group: 39
|
Case: Hemophilia Society of Turkey
Control: Istanbul University Faculty of Dentistry, Department of Pedodontics
|
Gingival Condition (GI- Loe & Silness)
Dental Plaque (Plaque Index - PI)
Dental Caries (DMFT/S–dmft/s)
|
0.39±0.48
0.88±0.42
DMFT: 3.44±3.30
DMFS: 5.78±6.64
dmft: 3.44±3.43
dmfs: 5.89±6.57
|
0.15±0.14
0.72±0.37
DMFT: 1.37±1.62
DFMS: 2.45±4.04
dmft: 3.24±2.62
dmfs: 6.32±6.84
|
Azhar et al., Pakistan [1212 Azhar S, Yazdanie N, Muhammad N. Periodontal status and IOTN interventions among young hemophiliacs. Haemophilia 2006; 12(4):401-4. https://doi.org/10.1111/j.1365-2516.2006.01305.x https://doi.org/10.1111/j.1365-2516.2006...
] |
Comparative Cross-Section |
Case: 16.59±3.24
Control: 16.70±2.95
|
Total: 244
Severe Hemophilia A and B: 52
Control: 192
|
Case: Hospital of Pakistan Hemophilia Society
Control: Lahore students
|
Dental caries (DMFT) With symptoms of Temporomandibular Joint Dysfunction Syndrome |
57.68%
13.45%
|
40.62%
2.08%
|
Babu et al., India [55 Leite RB, Nascimento RNM, Soares RSC, Marssoni ACLT, Barboza CAG, Gomes RCB. Knowledge of dentists in the care of patients with hereditary coagulopathies. RFO UPF 2018; 23(2):150-5. https://doi.org/10.5335/rfo.v23i2.8202 https://doi.org/10.5335/rfo.v23i2.8202...
] |
Comparative Cross-Section |
Total: [6-16] |
Total: 200
Hemophilia A: 98
Hemophilia B: 2 (Hemophilia Severity: Mild, 32; Moderate, 20; Severe, 48)
Control: 100
|
Case: Hemophilia Society of Bangalore, India
Control: V.S. Dental College and Hospital, Bangalore
|
Dental Caries (DMFT/dmft)
Dental Plaque (Plaque Index - PI)
Gingival condition (Modified Gingival Index – MGI)
|
DMFT: 4.0 (2.0,5.0)
dmft: 3.0 (2.0,3.0)
1.0 (1.0,2.0)
2.0 (1.0,2.0)
|
DMFT: 1.0 (1.0,2.0)
dmft: 2.0 (1.0,3.0)
1.0 (1.0,1.0)
0 (0.0,1.0)
|
Boyd & Kinirons, Northern Ireland [99 Boyd D, Kinirons M. Dental caries experience of children with haemophilia in Northern Ireland. Int J Paediatr Dent 1997; 7(3):149-53. https://doi.org/10.1046/j.1365-263x.1997.00231.x https://doi.org/10.1046/j.1365-263x.1997...
] |
Comparative Cross-Section |
Total: [2-15] |
Total: NR
Hemophilia: 38
Control: NR
|
Case: Royal Belfast Hospital for Sick Children.
Control: Prior published population data for children in Northern Ireland
|
Dental Caries (DMFT/dmft) |
DMFT: 27%
dmft: 44%
|
DMFT: 59%
dmft: 55%
|
Daneswari & Reddy, India [3232 Daneswari V, Reddy A. Oral hygiene status and treatment needs among haemophilic children in Telangana State and Andhra Pradesh State. Ann Med Res 2017; 7(3):28-31.] |
Cross-Sectional |
Total: [5-15] |
Total: 328
Hemophilia: 328
|
Mamata Dental College, Khammam |
Debris (Debris Index - DI)
Calculus (Calculus Index - CI)
Oral hygiene (Simplified Oral Hygiene Index - OHI-S)
Dental Caries (DMFT/deft)
|
5-7 years: 1.60
11-15 years: 1.95
5-7 years: 1.61
11-15 years: 1.277
5-7 years: 3.21
11-15 years: 3.22
5-7 years: DMFT: 2.81
deft: 3.23
11-15 years: DMFT: 5.92
deft: 2.27
|
NR
NR
NR
NR
|
Dogan et al., Turkey [1717 Dogan C, Sasmaz I, Antmen B, Seydaoglu G, Yazicioglu I. Physical and perceptional oral health status of children with hemophilia A. Haemophilia 2010; 16:51.] |
Comparative Cross-Section |
Total: 9.5 ± 3.5 [4-16] |
Total: 60
Severe Hemophilia A: 30
Control: 30
|
Cukurova University, Istambul |
Dental Caries (DMFT/DMFS)
Gingival condition (Gingival Index - GI)
Severity of gingival inflammation (NR) 2.00±0.74
|
DMFT: 5.07±3.5
DMFS: 9.07±0.74
0.66±0.72
2.00±0.74
|
DMFT: 4.17±2.5
DMFS: 8.30±5.4
0.32±0.25
1.60±0.49
|
Evangelista et al., Brazil [3535 Evangelista LM, Lima CCB, Idalino RCL, Lima MDM, Moura LFAD. Oral health in children and adolescents with haemophilia. Haemophilia 2015; 21(6):778-83. https://doi.org/10.1111/hae.12717 https://doi.org/10.1111/hae.12717...
] |
Cross-Sectional |
Total: [2-18] |
Total: 40
Hemophilia: 40
|
Hematology and Hemotherapy Center of Piauí (HEMOPI) |
Gingival bleeding (Gingival Bleeding Index - GBI)
Dental Caries (DMFT/dmft)
|
0-5 years: 18.4%
6-10 years: 42.1%
11-18 years: 39.5%
0-5 years: dmft: 45%
6-10 years: DMFT: 38.5%
dmft: 87.5%
11-18 years: DMFT: 73.3%
|
NR
NR
|
Hermida Bruno et al., Uruguay [1818 Hermida Bruno ML, Álvarez Loureiro L, Lewis W, Gabriel L, Boggia Tutaglio B, Segovia A, et al. Situación de salud oral de niños uruguayos portadores de coagulopatías hereditarias: Centro Hospitalario Pereira Rossell, Montevideo, Uruguay. Univ Odontol 2011; 30(64):31-5. [In Spanish].] |
Retrospective of Cases and Control |
Case: 8.62±4.20 [2-12]
|
Total: 117
Hemophilia A: 17
Hemophilia B: 7
Others Congenital
Coagulation Disorders: 15
Control: 78
|
Case: Hemotherapy Service Montevideo
Control: Dental Polyclinic of same healthcare center
|
Dental Caries (DMFT/dmft)
Gingivitis (Gingival Index) Malocclusion
|
DMFT: 1.96±2.59
dmft: 2.85±2.41
43%
39%
|
DMFT: 2.85 ± 2.41
dmft: 2.13± 2.36
NR
NR
|
Jangra & Goswami, India [1010 Jangra B, Goswami M. Assessment of dental caries experience and periodontal health status among children with haemophilia in New Delhi, India - a case control study. Oral Health Prev Dent 2017; 15(2):131-7. https://doi.org/10.3290/j.ohpd.a37925 https://doi.org/10.3290/j.ohpd.a37925...
] |
Case-Control |
Total: [2-14] |
Total: 110
Hemophilia A: 50
Hemophilia B: 5
Control: 55
|
Maulana Azad Institute of Dental Sciences, New Delhi-Department of Pedodontics and Preventive Dentistry |
Dental Caries (DMFT/S -dmft/s)
Dental Plaque (Plaque Index -Silness & Löe)
|
DMFT: 0.47±0.87
DMFS: 0.56±1.17
dmft: 2.02±2.4
dmfs: 4.71± 7.3
1.37±0.56
|
DMFT: 0.96±1.32
DMFS: 1.60±2.97
dmft: 4.38±4.2
dmfs: 9.85±11.2
1.29±0.52
|
Kozma et al., Romania [1313 Kozma A, Clevet O, Traila A, Ursu E, Jinca C, Oancea R, et al. The impact of replacement therapy on dental health in haemophilia. Rom J Leg Med 2019; 27(2):200-4. https://doi.org/10.4323/rjlm.2019.200 https://doi.org/10.4323/rjlm.2019.200...
] |
Comparative Cross-Section |
Case:
Children: 9.4±3.8
Adults: 34.8 ± 9.8
Control:
Children: 9.2±3.7
Adults: 38.2±8.5
|
Total: 94
Hemophilia A: 42
Hemophilia B: 5 (12 children)
Control: 47 (12 children)
|
NR |
Dental Caries (DMFT)
Dental Plaque (Plaque Index - PI)
|
3.5±3.5
1.5±0.5
|
3.8±3.2
0.8±0.7
|
Kumar et al., India [1414 Kumar M, Pai KM, Kurien A, Vineetha R. Oral hygiene and dentition status in children and adults with hemophilia: A case-control study. Spec Care Dentist 2018; 38(6):391-4. https://doi.org/10.1111/scd.12324 https://doi.org/10.1111/scd.12324...
] |
Case-Control |
Case: [2-71]
Control: [2-73]
|
Total: 200
Hemophilia: 100 (41 children)
Control: 100 (36 children)
|
Hemophilia Society, and Oral Diagnosis Clinic |
Dental Caries (DMFT - dmft)
Oral hygiene/Dental Plaque (OHI-S/PI)
|
3.51± 3.48
2.176±1.58
|
3.50±3.20
1.721± 1.36
|
Mazzoni & Pignatari, Brazil [1515 Mazzoni A, Pignatari SSN. Prevalência de cárie e aspectos periodontais em crianças e adolescentes portadores de hemofilia tipo A e B. Rev Paul Odontol 2009; 31(2):27-30. [In Portuguese].] |
Case-Control |
Total: 7.24 [3-12] |
Total: 58
Hemophilia A: 28
Hemophilia B: 1 (Hemophilia Severity: Mild, 3; Moderate, 10; Severe, 16)
Control: 29
|
Pediatric Otorhinolaryngology Clinic at UNIFESP and Hemophilia Clinic at Faculty of the Paulista School of Medicine |
Dental Caries (DMFT/dmft)
Gingival Condition (Gingival Bleeding Index – GBI - Ainano Bay)
Dental Plaque (Bacterial Plaque Index- O´Leary)
|
DMFT: 1.05 ± 1.50
dmft: 5.04±4.71
9.47±4.51
55.18±13.63
|
DMFT: 1.45 ± 2.04
dmft: 4.08± 3.45
9.97±6.18
48.13±13.28
|
Mielnik-Blaszczak, Poland [1616 Mielnik-Blaszczak M. Evaluation of dentition status and oral hygiene in Polish children and adolescents with congenital haemorrhagic diatheses. Int J Paediatr Dent 1999; 9(2):99-103. https://doi.org/10.1046/j.1365-263x.1999.00112.x https://doi.org/10.1046/j.1365-263x.1999...
] |
Comparative Cross-Section |
Total: [4-18] |
Total: 160
Hemophilia A: 70
Hemophilia B: 7 (Hemophilia Severity: Mild, 5; Moderate, 23; Severe, 49)
Others Congenital
Coagulation Disorders: 3
Control: 80
|
Regions of Lublin, Zamosc and Rzeszów |
Dental Caries (DMFT/S-dmft/s)
Oral hygiene (Simplified Oral Hygiene Index - OHI-S)
|
DMFT: 5.8
dmft: 4.1
DMFS: 9.6±10.5
dmfs: 10.1± 13.0
1.04
|
DMFT: 5.4
dmft: 4.6
DMFS: 8.5 ± 8.42
dmfs: 10.2±8.62
0.81
|
Mythri et al., India [3333 Mythri H, Jagdish GR, Chandu GN. Dental caries experience among haemophilic children. RJPBCS 2013; 4(4):1233-8.] |
Cross-Sectional |
Total: [2-15] |
Total: 20
Hemophilia A: 11
Hemophilia B: 7
Hemophilia C: 2 (Hemophilia Severity: Mild, 1; Moderate, 9; Severe, 10)
|
Karnataka hemophilia society at Davangere city |
Dental Caries (DMFT/dft) |
2-12 years 82.36%
7-15 years 28.52%
|
NR |
Othman et al., Malaysia [44 Othman NA, Sockalingam SN, Mahyuddin A. Oral health status in children and adolescents with haemophilia. Haemophilia 2015; 21(5):605-11. https://doi.org/10.1111/hae.12657 https://doi.org/10.1111/hae.12657...
] |
Case-Control |
Total: [7-16]
Case group:
11.74±0.36
Control group:
12.02±0.22
|
Total: 100
Hemophilia A: 41
Hemophilia B: 8
Other type of hemophilia: 1
Control: 50
|
Case group: National Blood Centre, Kuala Lumpur
Control group: subjects were selected during an oral health-screening program
|
Dental caries (DMFT/dtf)
Oral Hygiene (Simplified Oral Hygiene Index - OHI-S)
Simplified Debris Index (DI-S)
Simplified Calculus Index (CI-S)
Gingival Condition (Modified Gingival Index - MGI)
|
DMFT: 0.66±1.30
dft: 1.71± 2.69
1.02±0.86
0.87±0.62
0.15±0.39
0.33±0.39
|
DMFT: 0.74±1.07
dft: 1.27 ± 1.62
1.23±0.81
0.95±0.51
0.28±0.39
0.50±0.47
|
Rajantie et al., Finland [3838 Rajantie H, Alapulli H, Makipernaa A, Ranta S. Oral health care in children with haemophilia in Helsinki, Finland. European Archives of Paediatric Dentistry 2013; 14(5):339-43. https://doi.org/10.1007/s40368-013-0090-z https://doi.org/10.1007/s40368-013-0090-...
] |
Retrospective |
Total: 11.4 [5.3-17.4] |
Total: 28
Hemophilia A: 21
Hemophilia B: 7 (Hemophilia Severity: Mild, 4; Moderate, 5; Severe, 19)
*Group comprised 17.079 boys (public dental clinics in the Helsinki region)
|
Children’s Hospital, Helsinki University Central Hospital |
Dental Caries (DMFT/dmft)
Periodontal Condition (Community Periodontal Index - CPI)
Gingivitis Condition (Community Periodontal Index - CPI)
|
61%
29%
32%
|
NR
NR
NR
|
Reddy et al., India [3434 Reddy KS, Reddy NV, Niharika P, Reddy MA, Danaeswari V, Noorjahan M. Oral health status and treatment needs among hemophilic children in Hyderabad, Telangana, India. Int J Clin Pediatr Dent 2019; 12(1):30-2. https://doi.org/10.5005/jp-journals-10005-1585 https://doi.org/10.5005/jp-journals-1000...
] |
Cross-Sectional |
Total: [7-16] |
Total: 60
Hemophilia: 60
|
Hyderabad Haemophilic Society |
Dental Caries (DMFT/DEFT)
Oral Hygiene (Simplified Oral Hygiene Index - OHI-S)
|
DMFT + DEFT
3.90±1.972
1.52±0.776
|
NR
NR
|
Rodrigues et al., Brazil [3737 Rodrigues LV, Camelo Moreira MDS, de Oliveira CR, de Medeiros JJ, Lima Neto EA, Gondim Valenca AM. Factors associated with toothache in patients affected by hereditary coagulopathies. Pesqui Bras Odontopediatria Clin Integr 2017; 17(1):e3699. https://doi.org/10.4034/PBOCI.2017.171.37 https://doi.org/10.4034/PBOCI.2017.171.3...
] |
Cross-Sectional |
Total: 23.34 |
Total: 106
Hemophilia A: 81
Others Congenital
Coagulation Disorders: 25
|
Two Blood Centers of the state of Paraiba (cities of João Pessoa and Campina Grande) |
Dental Caries (DMFT) |
50% |
NR |
Rodrigues et al., Brazil [3636 Rodrigues MJ, Luna ACA, Leal LC, Lira SS, Marques KM. Prevalence of caries and associated factors in hemophiliac children. Rev Bras Hematol Hemoter 2008; 30(2):114-9. https://doi.org/10.1590/S1516-84842008000200008 https://doi.org/10.1590/S1516-8484200800...
] |
Cross-Sectional |
Total: [3-12] |
Total: 40
Hemophilia: 40
|
Pernambuco Hemotherapy Center (HEMOPE) |
Dental Caries (DMFT/dmft) |
DMFT: 0.67±1.22
dmft: 2.00±2.32
|
NR |
Salem & Eshghi, Iran [3131 Salem K, Eshghi P. Dental health and oral health-related quality of life in children with congenital bleeding disorders. Haemophilia 2013; 19(1):65-70. https://doi.org/10.1111/hae.12002 https://doi.org/10.1111/hae.12002...
] |
Comparative Cross-Section |
Total: [2-15]
Case group:
7.6±4.20
Control group:
7.5± 3.4
|
Total: 92
Hemophilia A: 35
Hemophilia B: 4
Others Congenital Coagulation Disorders: 7
Control: 46
|
Centre for CBD in Tehran |
Dental Caries (DMFT/DMFTS/dmft/dmfs)
History of Oral Bleeding Occlusion
TJD (WHO)
Hypoplasia (WHO)
Oral hygiene (Simplified Oral Hygiene Index - OHI-S)
|
DMFT: 1.13±2.18
dmft: 4.88±4.57
DMFS: 1.30±2.43
dmfs: 10.58±12.23
DMFT: 1.34±2.08
dmft: 4.95±4.31
55%
Protusion: 15.2%
Retrusion: 0%
8.7%
14.28%
0.82±0.41
|
DMFS: 1.62±2.7
dfms: 12.71 ± 15.31
NR
Protusion: 19.6%
Retrusion: 4.3%
13%
17.85%
0.91±0.62
|
Salem et al., Iran [1919 Salem K, Seyyedkhamesi S, Aminian M. Evaluation of oral and dental health status in hemophilic children and adolescents in the city of Rasht. J Pediatr Res 2018; 5(4):182-6. https://doi.org/10.4274/jpr.80037 https://doi.org/10.4274/jpr.80037...
] |
Case-Control |
Total: [2-15] |
Total: 106
Hemophilia A: 49
Hemophilia B: 3
Factor XII: 1 (Hemophilia Severity: Mild, 11; Moderate, 14; Severe, 28)
Control group: 53
|
Rasht, Iran |
Dental Caries (DMFT/DMFS -dmft/dmfs)
Dental Plaque (Plaque Index - PI – The O’Leary index)
Gingival Condition (Modified Gingival Index – Loe and Silness)
|
DMFT: 2.75±2.71
dmft: 2.83±3.06
DMFS: 3.79±4.1
dmfs: 4.9±6.2
81.87±15.43
1.86±0.8
|
DMFT: 1.98±2.51
dmft: 3.13±3.21
DMFS: 2.03±4.05
dmfs: 6.58±7.33
72.78±18.94
1.75±1.1
|
Sonbol et al., England [2020 Sonbol H, Pelargidou M, Lucas VS, Gelbier MJ, Mason C, Roberts GJ. Dental health indices and caries-related microflora in children with severe haemophilia. Haemophilia 2001; 7(5):468-74. https://doi.org/10.1046/j.1365-2516.2001.00536.x https://doi.org/10.1046/j.1365-2516.2001...
] |
Case-Control |
Case group: 8.8±3.4 [3-13.6]
Control group:
9.8± 3.1 [4-15.3]
|
Total: 60
Severe Hemophilia: 30
Control: 30
|
Case: Great Ormond Street Hospital for Children
Control: Eastman Dental Institute
|
Dental Caries (DMFT/S-dmft/s)
Dental Plaque (Plaque Index - PI – The O’Leary index)
Gingivitis (Simplified Gingival Index)
|
DMFT: 0.7±1.3
dmft: 2.3±2.8
DMFS: 0.8±1.5
dmfs: 6.1±11.1
Primary dentition: 20.8±18.8
Permanent dentition: 15.8±19.5
Primary dentition: 1.3±5.4
Permanent dentition: 1.7±5.8
|
DMFT: 2.4±2.8
dmft: 2.9±3.7
DMFS: 3.6±3.8
dmfs: 5.5±6.2
Primary dentition: 20.5±21.8
Permanent dentition: 34.7±19.9
Primary dentition: 2.5±6.5
Permanent dentition: 5±10.7
|
Vujkov et al., Serbia [3939 Vujkov S, Bajkin B, Blagojevic D, Petrovic B, Konstantinidis N, Rajic N, et al. Oral health in children and young adults with hemophilia in Serbia. Haemophilia 2014; 20:128.] |
Case-Control |
[10-25] |
Total: 73
Hemophilia: 33
Control: 40
|
NR |
Dental Caries (DMF)
Gingival condition (Gingival Index)
Oral hygiene (Oral Hygiene Index)
|
4.21± 4.14
1.57±0.77
1.54±0.70
|
4.45±4.19
0.12±0.35
0.28±0.48
|
Yazicioglu et al., Turkey [2121 Yazicioglu I, Deveci C, Çiftçi V, Antmen B, Doğan MC. Parent’s report on oral health-related quality of life of children with haemophilia. Haemophilia 2019; 25(2):229-35. https://doi.org/10.1111/hae.13678 https://doi.org/10.1111/hae.13678...
] |
Comparative Cross-Section |
Total: [2-14] |
Total: 300
Hemophilia: 76
Control: 224
|
NR |
Dental Caries (DFMT/dmft)
Oral hygiene (NR)
|
DMFT: 1.30
dmft: 3.5
Good: 34.2%
Fair: 43.4%
Bad: 22.4%
|
DMFT: 0.91
dmft: 2.6
Good: 36.2%
Fair: 41.1%
Bad: 22.8%
|
Zaliuniene et al., Lithuania [1111 Zaliuniene R, Aleksejuniene J, Peciuliene V, Brukiene V. Dental health and disease in patients with haemophilia - a case-control study. Haemophilia 2014; 20(3):e194-e8. https://doi.org/10.1111/hae.12325 https://doi.org/10.1111/hae.12325...
] |
Case-Control |
Total: 26.1 ± 14.4 [4-58] |
Total: 155
Hemophilia: 76 (27 children)
Control: 79 (30 children)
|
Case: National Register of Hemophilia patients
Control: General population
|
Dental Caries (DMFT/dft) |
DMFT: 9.4±7.6
dft: 2.6±2.6
|
DMFT: 9.3±7.0
Dft: 6.1±2.5
|
Zaliuniene et al., Lithuania [2222 Zaliuniene R, Aleksejuniene J, Brukiene V, Peciuliene V. Do hemophiliacs have a higher risk for dental caries than the general population? Medicina 2015; 51(1):46-56. https://doi.org/10.1016/j.medici.2015.01.003 https://doi.org/10.1016/j.medici.2015.01...
] |
Case-Control |
Total: 26.1±14.4 [4-58] |
Total: 155
Hemophilia: 76 (27 children)
Control: 79 (30 children)
|
Case: National Register of Hemophilia patients
Control: General population
|
Dental Caries (DMFT/dft)
Dental Plaque (Quantitative Plaque Percent Index - P% index)
|
DMFT: 9.4±7.6
dft: 2.6±2.6
32.0±20.2
|
DMFT: 9.3±7.0
dft: 6.1±2.5
28.2±15.2
|