Implications of Vitamin D Status for Children’s Bone Health: A Data Mining Analyses of Observational Studies

Martins, Mariana Leonel; Arrepia, Beatriz Fernandes; Jural, Lucas; Vicente-Gomila, José; Masterson, Daniele; Maia, Lucianne Cople; Visconti, Maria Augusta; Fonseca-Gonçalves, Andréa

doi:10.1590/pboci.2024.048

Mariana Leonel Martins

Formal Analysis

Data Curation

Writing - Original Draft

Writing - Review

Editing

Funding Acquisition.

Department of Pediatric Dentistry and Orthodontics, School of Dentistry, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil

https://orcid.org/0000-0001-6777-3225

Beatriz Fernandes Arrepia

Conceptualization

Methodology

Formal Analysis

Investigation

Data Curation

Writing - Original Draft.

Department of Pediatric Dentistry and Orthodontics, School of Dentistry, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil

https://orcid.org/0000-0001-5184-3006

Lucas Jural

Methodology

Formal Analysis

Investigation

Data Curation.

Department of Pediatric Dentistry and Orthodontics, School of Dentistry, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil

https://orcid.org/0000-0002-9772-1562

José Vicente-Gomila

Conceptualization

Software

Writing - Review

Editing.

Department of Enterprise Management, ESIC Business & Marketing School, Madrid, Spain

https://orcid.org/0000-0003-2001-8964

Daniele Masterson

Conceptualization

Writing - Review

Editing

Central Library of the Health Science Center, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil

https://orcid.org/0000-0001-7108-1117

Lucianne Cople Maia

Conceptualization

Software

Formal Analysis

Writing - Review

Editing

Department of Pediatric Dentistry and Orthodontics, School of Dentistry, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil

https://orcid.org/0000-0003-1026-9401

Maria Augusta Visconti

Conceptualization

Methodology

Formal Analysis

Data Curation

Writing - Review

Editing

Supervision

Project Administration

Department of Pathology and Oral Diagnosis, Dental School, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil

https://orcid.org/0000-0002-8837-8387

Andréa Fonseca-Gonçalves Corresponding author: Andréa Fonseca-Gonçalves E-mail:andrea.goncalves@odonto.ufrj.br

Conceptualization

Software

Formal Analysis

Data Curation

Writing - Review

Editing

Supervision

Project Administration

Department of Pediatric Dentistry and Orthodontics, School of Dentistry, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil

https://orcid.org/0000-0001-6467-7078

Corresponding author: Andréa Fonseca-Gonçalves E-mail:andrea.goncalves@odonto.ufrj.br

Academic Editor: Alessandro Leite Cavalcanti

Conflict of Interest

Database	Strategy
PubMed	((Vitamin D[Mesh] OR Vitamin D[Tiab] OR Cholecalciferol[Mesh]) OR Cholecalciferol[Tiab] OR Vitamin D3[Tiab] OR Ergocalciferols[Mesh] OR Ergocalciferol^[Tiab] OR Calcitriol[Mesh] OR Calcitriol[Tiab] OR "dihydroxyvitamin D" AND (child[mesh] OR child^[tiab] OR Child, Preschool[Mesh] OR Infant[mesh] OR Infant^[tiab] OR pre-school^[tiab] OR preschool^*[tiab])) AND (observational[tiab] OR Prospective studies[Mesh] OR prospective study[tiab] OR cohort studies[Mesh] OR cohort[tiab] OR follow-up studies[Mesh] OR follow-up study[tiab] OR case-control studies[Mesh] OR case control[tiab] OR retrospective studies[Mesh] OR cross-sectional studies[Mesh] OR cross-sectional[tiab] OR "Disease Frequency"[tiab] OR "prevalence study"[tiab])
Scopus	( ( ( TITLE-ABS-KEY ( "Vitamin D" ) OR TITLE-ABS-KEY ( "dihydroxyvitamin D" ) OR TITLE-ABS-KEY ( cholecalciferol ) OR TITLE-ABS-KEY ( "Vitamin D3" ) OR TITLE-ABS-KEY ( ergocalciferols ) OR TITLE-ABS-KEY ( calcitriol ) ) ) AND ( ( TITLE-ABS-KEY ( child^* ) OR TITLE-ABS-KEY ( preschool^* ) OR TITLE-ABS-KEY ( pre-school^* ) OR TITLE-ABS-KEY ( infant^* ) ) ) ) AND ( ( TITLE-ABS-KEY ( observational ) OR TITLE-ABS-KEY ( "prospective study" ) OR TITLE-ABS-KEY ( cohort ) OR TITLE-ABS-KEY ( "follow-up study" ) OR TITLE-ABS-KEY ( "case control" ) OR TITLE-ABS-KEY ( "retrospective study" ) OR TITLE-ABS-KEY ( "cross-sectional" ) OR TITLE-ABS-KEY ( "Disease Frequency" ) OR TITLE-ABS-KEY ( "prevalence study" ) ) )
Web of Science	((TS=(((((("Vitamin D") OR ("dihydroxyvitamin D")) OR (cholecalciferol)) OR ("Vitamin D3")) OR (ergocalciferol)) OR (calcitriol))) AND (TS=((((child^) OR (preschool^)) OR (pre-school^)) OR (infant^)))) AND (TS=(((((((((observational) OR ("prospective study")) OR (cohort)) OR ("follow-up study")) OR ("case-control")) OR ("retrospective study")) OR ("cross-sectional")) OR ("Disease Frequency")) OR ("prevalence study")))
Embase	('vitamin d':ti,ab,kw OR 'dihydroxyvitamin d':ti,ab,kw OR cholecalciferol:ti,ab,kw OR 'vitamin d3':ti,ab,kw OR ergocalciferols:ti,ab,kw OR calcitriol:ti,ab,kw) AND (child^:ti,ab,kw OR 'preschool^':ti,ab,kw OR infant^*:ti,ab,kw) AND (observational:ti,ab,kw OR 'prospective study':ti,ab,kw OR cohort:ti,ab,kw OR 'follow up':ti,ab,kw OR 'case control':ti,ab,kw OR 'retrospective study':ti,ab,kw OR 'cross-sectional':ti,ab,kw OR 'disease frequency':ti,ab,kw OR 'prevalence study':ti,ab,kw)

	Outcome			Vitamin D		Exams					Results
Authors	Bone Quality	Bone Fracture	Anthropometric Measures	Serum levels^* * 25-hydroxyvitamin D; +With association; -Without association.	Intake levels	Dual-Energy X-ray Absorptiometry	Radiograph	Peripheral Quantitative Computed Tomography	Ultrasound	No images	Association (Positive or Negative)
Al-Ghamdi et al. [¹¹[11] Al-Ghamdi MA, Lanham-New SA, Kahn JA. Differences in vitamin D status and calcium metabolism in Saudi Arabian boys and girls aged 6 to 18 years: effects of age, gender, extent of veiling and physical activity with concomitant implications for bone health. Public Health Nutr 2012;15(10):1845-53. https://doi.org/10.1017/S1368980011003612 https://doi.org/10.1017/S136898001100361... ]	+			+		+			+		º
Breen et al.[¹²[12] Breen ME, Laing EM, Hall DB, Hausman DB, Taylor RG, Isales CM, et al. 25-hydroxyvitamin D, insulin-like growth factor-I, and bone mineral accrual during growth. J Clin Endocrinol Metab 2011; 96(1):E89-98. https://doi.org/10.1210/jc.2010-0595 https://doi.org/10.1210/jc.2010-0595... ]	+		+	+		+					•
Das et al. [¹³[13] Das S, Sanchez JJ, Alam A, Haque A, Mahfuz M, Ahmed T, et al. Dietary Magnesium, Vitamin D, and Animal Protein Intake and Their Association to the Linear Growth Trajectory of Children from Birth to 24 Months of Age: Results From MAL-ED Birth Cohort Study Conducted in Dhaka, Bangladesh. Food Nutr Bull 2020; 41(2):200-210. https://doi.org/10.1177/0379572119892408 https://doi.org/10.1177/0379572119892408... ]			+		+						•
El-Sakka et al. [¹⁴[14] El-Sakka A, Penon C, Hegazy A, Elbatrawy S, Gobashy A, Moreira A. Evaluating bone health in Egyptian children with forearm fractures: A case control study. Int J Pediatr 2016; 2016:7297092. https://doi.org/10.1155/2016/7297092 https://doi.org/10.1155/2016/7297092... ]	+		+	+	+	+					º
Filteau et al. [¹⁵[15] Filteau S, Rehman AM, Yousafzai A, Chugh R, Kaur M, Sachdev HP, et al. Associations of vitamin D status, bone health and anthropometry, with gross motor development and performance of school-aged Indian children who were born at term with low birth weight. BMJ Open 2016; 6(1):e009268. https://doi.org/10.1136/bmjopen-2015-009268 https://doi.org/10.1136/bmjopen-2015-009... ]	+		+	+					+	•	º
Fu et al. [¹⁶[16] Fu Y, Hu Y, Qin Z, Zhao Y, Yang Z, Li Y, et al. Association of serum 25-hydroxyvitamin D status with bone mineral density in 0-7 year old children. Oncotarget 2016; 7(49):80811-80819. https://doi.org/10.18632/oncotarget.13097 https://doi.org/10.18632/oncotarget.1309... ]	+			+							º
Garcia et al. [¹⁷[17] Garcia AH, Erler NS, Jaddoe VWV, Tiemeier H, van den Hooven EH, Franco OH, et al. 25-hydroxyvitamin D concentrations during fetal life and bone health in children aged 6 years: a population-based prospective cohort study. Lancet Diabetes Endocrinol 2017; 5(5):367-376. https://doi.org/10.1016/S2213-8587(17)30064-5 https://doi.org/10.1016/S2213-8587(17)30... ]	+			+		+					º
Herrmann et al. [¹⁸[18] Herrmann D, Pohlabeln H, Gianfagna F, Konstabel K, Lissner L, Mårild S, et al. Association between bone stiffness and nutritional biomarkers combined with weight-bearing exercise, physical activity, and sedentary time in preadolescent children. A case-control study. Bone. 2015; 78:142-9. https://doi.org/10.1016/j.bone.2015.04.043 https://doi.org/10.1016/j.bone.2015.04.0... ]	+		+	+					+		-
James et al. [¹⁹[19] James JR, Massey PA, Hollister AM, Greber EM. Prevalence of hypovitaminosis D among children with upper extremity fractures. J Pediatr Orthop 2013; 33(2):159-62. https://doi.org/10.1097/BPO.0b013e3182770bf7 https://doi.org/10.1097/BPO.0b013e318277... ]		+		+						+	+
Mäyränpää et al. [²⁰[20] Mäyränpää MK, Viljakainen HT, Toiviainen-Salo S, Kallio PE, Mäkitie O. Impaired bone health and asymptomatic vertebral compressions in fracture-prone children: a case-control study. J Bone Miner Res 2012; 27(6):1413-24. https://doi.org/10.1002/jbmr.1579 https://doi.org/10.1002/jbmr.1579... ]	+	+		+		+					+
McVey et al. [²¹[21] McVey MK, Geraghty AA, O'Brien EC, McKenna MJ, Kilbane MT, Crowley RK, et al. The impact of diet, body composition, and physical activity on child bone mineral density at five years of age-findings from the ROLO Kids Study. Eur J Pediatr 2020; 179(1):121-131. https://doi.org/10.1007/s00431-019-03465-x https://doi.org/10.1007/s00431-019-03465... ]			+	+		+					-
Mercy et al. [²²[22] Mercy J, Dillon B, Morris J, Emmerson AJ, Mughal MZ. Relationship of tibial speed of sound and lower limb length to nutrient intake in preterm infants. Arch Dis Child Fetal Neonatal Ed 2007; 92(5):F381-5. https://doi.org/10.1136/adc.2006.105742 https://doi.org/10.1136/adc.2006.105742... ]			+		+				+		+
Minkowitz et al. [²³[23] Minkowitz B, Cerame B, Poletick E, Nguyen JT, Formoso ND, Luxenberg SL, et al. Morris-Essex Pediatric Bone Health Group. Low vitamin D lLevels are associated with need for surgical correction of pediatric fractures. J Pediatr Orthop 2017; 37(1):23-29. https://doi.org/10.1097/BPO.0000000000000587 https://doi.org/10.1097/BPO.000000000000... ]		+		+						+	+
Nguyen et al. [²⁴[24] Nguyen PM, Pham LV, Nguyen KT, Nguyen DP, Nguyen HD, Lai NV, et al. Vitamin D and bone mineral density status, and their correlation with bone turnover markers in healthy children aged 6-14 in Vietnam. Curr Pediatr Res 2020; 24(3):204-209.]		+	+	+		+					-
Oladosu et al. [²⁵[25] Oladosu MA, Esan O, Oginni LM, Adegbehingbe OO, Adedeji TA. (2021). Predictive value of serum vitamin D3 level for forearm fractures among children in a tropical country: A case control study. J Clin Diag Res 2021; 15(1):RC01-RC04. https://doi.org/10.7860/JCDR/2021/44836.14453 https://doi.org/10.7860/JCDR/2021/44836.... ]		+		+						+	+
Rajakumar et al. [²⁶[26] Rajakumar K, Fernstrom JD, Janosky JE, Greenspan SL. Vitamin D insufficiency in preadolescent African American children. Clin Pediatr 2005; 44(8):683-692. https://doi.org/10.1177/000992280504400806 https://doi.org/10.1177/0009922805044008... ]	+		+	+	+					+	-
Ren et al. [²⁷[27] Ren J, Brann LS, Bruening KS, Scerpella TA, Dowthwaite JN. Relationships among diet, physical activity, and dual plane dual-energy X-ray absorptiometry bone outcomes in pre-pubertal girls. Arch Osteoporos 2017; 12(1):19. https://doi.org/10.1007/s11657-017-0312-9 https://doi.org/10.1007/s11657-017-0312-... ]	+	+	+		+	+					+
Ryan et al. [²⁸[28] Ryan LM, Teach SJ, Brandoli C, Singer SA, Wood R, Freishtat RJ, et al. Predictors of forearm fracture risk in African American children. J Investig Med 2011; 59(3):634-635.]	+	+	+	+	+	+					+
Ryan et al. [²⁹[29] Ryan LM, Chamberlain JM, Singer SA, Wood R, Tosi LL, Freishtat RJ, et al. Genetic influences on vitamin D status and forearm fracture risk in African American children. J Investig Med 2012a; 60(6):902-906. https://doi.org/10.2310/JIM.0b013e3182567e2a https://doi.org/10.2310/JIM.0b013e318256... ]	+	+		+	+	+					-
Ryan et al.[³⁰[30] Ryan LM, Teach SJ, Singer SA, Wood R, Freishtat R, Wright JL, et al. Bone mineral density and vitamin D status among African American children with forearm fractures. Pediatrics 2012b; 130(3):e553-560. https://doi.org/10.1542/peds.2012-0134 https://doi.org/10.1542/peds.2012-0134... ]	+	+		+		+					-
Ryan et al. [³¹[31] Ryan LM, Devaney JM, Gordish-Dressman H, Stevens MW, Tosi L. Clinical factors associated with vitamin d deficiency in African American children with forearm fractures. J Investig Med 2014; 62(4):769-769.]	+	+		+		+					+
Sakamoto et al. [³²[32] Sakamoto Y, Ishijima M, Nakano S, Suzuki M, Liu L, Tokita A, et al. Physiologic leg bowing is not a physiologic condition but instead is associated with vitamin D disorders in toddlers. Calcif Tissue Int 2020; 106(2):95-103. https://doi.org/10.1007/s00223-019-00619-9 https://doi.org/10.1007/s00223-019-00619... ]	+			+			+				+
Sayers et al. [³³[33] Sayers A, Fraser WD, Lawlor DA, Tobias JH. 25-Hydroxyvitamin-D3 levels are positively related to subsequent cortical bone development in childhood: Findings from a large prospective cohort study. Osteoporos Int 2012; 23(8):2117-28. https://doi.org/10.1007/s00198-011-1813-9 https://doi.org/10.1007/s00198-011-1813-... ]	+			+				+			+
Sharawat at al. [³⁴[34] Sharawat IK, Dawman L. Bone mineral density and its correlation with vitamin D status in healthy school-going children of Western India. Arch Osteoporos 2019;14(1):13. https://doi.org/10.1007/s11657-019-0568-3 https://doi.org/10.1007/s11657-019-0568-... ]	+		+	+		+					+
Videhult et al. [³⁵[35] Videhult FK, Öhlund I, Hernell O, West CE. Body mass but not vitamin D status is associated with bone mineral content and density in young school children in northern Sweden. Food Nutr Res 2016; 60:30045. https://doi.org/10.3402/fnr.v60.30045 https://doi.org/10.3402/fnr.v60.30045... ]	+			+	+	+					-
White et al. [³⁶[36] White Z, White S, Dalvie T, Kruger MC, Van Zyl A, Becker P. Bone health, body composition, and vitamin D status of black preadolescent children in South Africa. Nutrients 2019; 11(6):1243. https://doi.org/10.3390/nu11061243 https://doi.org/10.3390/nu11061243... ]	+			+		+					-
Yorifuji et al. [³⁷[37] Yorifuji J, Yorifuji T, Tachibana K, Nagai S, Kawai M, Momoi T, et al. Craniotabes in normal newborns: the earliest sign of subclinical vitamin D deficiency. J Clin Endocrinol Metab 2008; 93(5):1784-8. https://doi.org/10.1210/jc.2007-2254 https://doi.org/10.1210/jc.2007-2254... ]	+		+	+			+				-

Journal	Years		Total	IF^* * IF: Impact Factor; The International Journal of Pediatrics doesn't have an IF classification.
	2002-2010	2011-2022
Journal of Investigative Medicine	0	3	3	3.235
Archives of Osteoporosis	0	2	2	3.236
Journal of Pediatric Orthopaedics	0	2	2	2.537
Journal of Clinical Endocrinology and Metabolism	1	1	2	4.756
Archives of Disease in Childhood: Fetal and Neonatal Edition	1	0	1	6.643
BMJ Open	0	1	1	3.007
Bone	0	1	1	4.626
Calcified Tissue International	0	1	1	4.227
Current Pediatric Research	0	1	1	2.05
European Journal of Pediatrics	0	1	1	3.860
Food and Nutrition Bulletin	0	1	1	2.751
Food and Nutrition Research	0	1	1	3.894
International Journal of Pediatrics	0	1	1	-
Journal of Bone and Mineral Research	0	1	1	6.390
Journal of Clinical and Diagnostic Research	0	1	1	1.148
Nutrients	0	1	1	7.185
Oncotarget	0	1	1	2.678
Osteoporosis International	0	1	1	4.507
Pediatrics	0	1	1	7.124
Pediatrics International	0	1	1	1.617
Public Health Nutrition	0	1	1	4.022
The Lancet Diabetes and Endocrinology	0	1	1	44.867

[1] Corresponding author: Andréa Fonseca-Gonçalves E-mail:andrea.goncalves@odonto.ufrj.br

Brasil

Brasil

Implications of Vitamin D Status for Children’s Bone Health: A Data Mining Analyses of Observational Studies

ABSTRACT

Objective:

Material and Methods:

Results:

Conclusion: