Physicochemical characterization, drug release and mechanical analysis of ibuprofen-loaded uhmwpe for orthopedic applications

Abstract

In this study, the preparation of a novel functional material for orthopedic implants using compression molding was investigated. The new functional material is envisioned to avoid inflammatory reactions in vivo after prosthesis implantation. Ibuprofen-loaded UHMWPE samples were prepared in two concentrations (3% and 5%) and samples were characterized in terms of physicochemical and mechanical properties. In addition, the drug-release profile was investigated. The manufacturing process resulted in a homogeneous polymer matrix with homogeneous drug dispersion. The addition of ibuprofen had a minor effect on physicochemical properties but a more significant influence on the mechanical behavior of the specimens was observed. Drug release was demonstrated and overall the results obtained showed a positive outcome with regard to the intended use. The properties analyzed remained within an acceptable range for medical application and the drug-release profile obtained for the material developed shows promise for its use as an anti-inflammatory system.

Keywords:
UHMWPE; ibuprofen; biomaterial; drug delivery; orthopedic implants; material characterization