In the last decade we have seen improved a powerfull tool to medicinal chemistry: the Solid Phase Organic Synthesis (SPOS). This metodology can be used to synthesize a large library of compounds in a short time by combinatorial chemistry, where simple chemical substances can be combinated one to each other building a library of complex compounds. In this work we present the solid phase organic synthesis and their advantage upon the tradicional organic synthesis methodology, as well as the main polimers used in the SPOS technique.
solid phase organic synthesis; polymer; drug design
