Comparison of neutrophil lymphocyte ratio, platelet lymphocyte ratio, and mean platelet volume and PCR test in COVID-19 patients

Özsari, Süleyman; Özsari, Emine; Emin Demirkol, Muhammet

doi:10.1590/1806-9282.67.Suppl1.20200630

home Sumário navigate_before Anterior Atual Seguinte navigate_next

home Sumário

Original Article • Rev. Assoc. Med. Bras. 67 (Suppl 1) • 2021 • https://doi.org/10.1590/1806-9282.67.Suppl1.20200630 linkcopy

Comparison of neutrophil lymphocyte ratio, platelet lymphocyte ratio, and mean platelet volume and PCR test in COVID-19 patients

Authorship SCIMAGO INSTITUTIONS RANKINGS

SUMMARY

OBJECTIVE: The polymerase chain reaction test, used in the diagnosis of COVID-19, can be positive with delay, and thorax tomography is used for the diagnosis of the disease. We aimed to compare the relation between thorax tomography findings, PCR test results, and neutrophil lymphocyte ratio; platelet lymphocyte ratio and mean platelet volume neutrophil lymphocyte ratio; platelet lymphocyte ratio and mean platelet volume in COVID-19 patients.

METHODS: COVID-19 patients were divided into three groups, according to baseline laboratory and thorax tomography findings: Group A: thorax tomography finding positive – polymerase chain reaction test positive; Group B: thorax tomography finding negative – polymerase chain reaction test positive; and Group C: thorax tomography finding positive – polymerase chain reaction test negative. Neutrophil lymphocyte ratio, platelet lymphocyte ratio, and mean platelet volume values were compared between these three groups.

RESULTS: Group C neutrophil lymphocyte ratio level and polymerase chain reaction level were statistically higher than that of group B (p<0.001 in both). Mean platelet volume was not statistically significant between groups (p>0.005 for all). A positive correlation was detected between neutrophil lymphocyte ratio and C-reactive protein (r=0.421, p<0.001). Similarly, positive correlation was found with polymerase chain reaction and C-reactive protein (r=0.243, p=0.001).

CONCLUSIONS: The thorax tomography finding can be detected earlier in the disease before the polymerase chain reaction test. The sensitivity of the polymerase chain reaction test varies according to the tester, the way of performing it, and the quality of the test. Therefore, especially in patients with polymerase chain reaction negative and thorax tomography findings, neutrophil lymphocyte ratio and platelet lymphocyte ratio levels should be evaluated, and patients should be followed up upon suspicion of COVID-19 diagnosis.

KEYWORDS: Neutrophils; Lymphocytes; Blood platelets; Mean platelet volume; Polymerase chain reaction; Coronavirus infections

	Group A	Group B	Group C	p
Mean±SD
Age (years old)	55.4±15	53.1±16.6	54.8±16.6	0.07
Urea (mg/dL)	33.9±1.1	32.2±1.4	44±2.2	<0.001
ALT (U/L)	37.1±3.7	23.8±1.5	38.8±3.7	0.1
GGT (U/L)	42.2±5.6	50±3.2	45±7.3	0.9
Total bilirubin (mg/dL)	0.91±0.25	0.90±0.33	0.97±0.34	0.4
Median (min–max)
NLR	2.1 (0.45–60)	1.92 (0.51–17.4)	3.5 (0.633–44.8)	0.004
PLR	144 (44–1000)	128 (12.8–323)	165 (49–650)	0.009
WBC (uL)	5.05 (2.5–10.6)	6.3 (2.1–19.8)	7.5 (2.6–28)	<0.001
NEU (uL)	3.25 (1.2–7.6)	3.3 (1.2–8.3)	4.6 (1.1–15.3)	<0.001
Lymp (uL)	1.4 (0.1–4.7)	1.7 (0.5–16)	1.35 (0.4–4.4)	0.06
MPV (fL)	8 (6.7–10)	8.32 (5.4–11)	8.05 (5.9–10)	0.89
RDW (%)	15.3 (12.5–27)	15.05 (11.9–24.5)	15.02 (12–20.1)	0.76
AST (U/L)	28 (11–90)	29 (14–90)	26 (9–130)	0.02
ALP (U/L)	86 (50–140)	76 (23–181)	77 (39–137)	0.76
CRP (mg/L)	21 (0.1–135)	4.45 (0.1–292)	43.4 (0.1–450)	0.001

vertical_align_top file_download show_chart

more_horizclose
- image
- translate
- link
- article
- vertical_align_top
- file_download
- show_chart
- image
- translate
- link
- article

location_on

Associação Médica Brasileira R. São Carlos do Pinhal, 324, 01333-903 São Paulo SP - Brazil, Tel: +55 11 3178-6800, Fax: +55 11 3178-6816 - São Paulo - SP - Brazil
E-mail: ramb@amb.org.br

rss_feed Acompanhe os números deste periódico no seu leitor de RSS

Acessibilidade / Reportar erro