Comparison of obstetric and perinatal complications in intracytoplasmic sperm injection cycles with autologous oocytes and donated oocytes

Horta, Valéria Cristina Datrino; Sá, Renato Augusto Moreira de; Lourenço, Marco Antônio Pessanha; Horta, Raphael Datrino; Horta, Rodrigo Datrino; Maldonado, Luiz Guilherme Louzada; Peixoto, Alberto Borges; Araujo Júnior, Edward

doi:10.1590/1806-9282.20240357

Acessibilidade / Reportar erro

Brasil

Revista da Associação Médica Brasileira

Español English

Brasil

Español English

sumário « anterior atual seguinte »

Sumário

Original Article • Rev. Assoc. Med. Bras. 70 (8) • 2024 • https://doi.org/10.1590/1806-9282.20240357 copy

Comparison of obstetric and perinatal complications in intracytoplasmic sperm injection cycles with autologous oocytes and donated oocytes

Authorship SCIMAGO INSTITUTIONS RANKINGS

SUMMARY

OBJECTIVE:

The aim of this study was to compare the obstetric and perinatal complications in women who became pregnant with autologous oocytes and those who received donated oocytes (DO) in intracytoplasmic sperm injection cycles (ICSI).

METHODS:

A retrospective cohort study was carried out by collecting data from medical records between 2019 and 2022. Only patients who underwent ICSI in an induced cycle using their own or freshly DO, with male infertility factor and tubal factor, were included.

RESULTS:

A total of 120 patients were assessed, comprising 51 cases utilizing their own oocytes (control group) and 69 cases employing DO (study group). Patients receiving DO (n=69) exhibited a significantly higher mean age compared to those utilizing their own oocytes (n=51) (41.96±2.16 vs 38.54±1.42 years, p<0.001). There was no significant association between the source of oocytes and gestational age at delivery (p=0.296), birth weight (p=0.836), admission to neonatal intensive care unit (ICU) (p=0.120), or maternal admission to adult ICU (p=0.767). Additionally, the origin of oocytes did not demonstrate any significant association with the risk of pre-eclampsia (p=0.357), gestational diabetes mellitus (p=0.187), premature rupture of membranes (p=0.996), uterine atony (p=0.996), placenta previa (p=0.393), oligohydramnios (p=0.393), or gestational hypertension (p=0.393)."

CONCLUSION:

An increase in obstetric and perinatal complications was not observed in pregnancies with DO compared to pregnancies with autologous oocytes in women undergoing ICSI without prior comorbidities. Further studies with larger sample sizes are required to validate our findings.

KEYWORDS:
ICSI; Oocyte donation; Pregnancy outcomes; Neonatal intensive care units

		Donated oocytes (N=69)	Own oocytes (N=51)	p
Age (years ± SD)		41.96 ± 2.16	38.54 ± 1.42	<0.001^¥ ¥ Chi-squared: % (n/N)
Ethnicity
	White	59.4% (41/69)	74.5% (38/51)	0.119^∂ ∂ p<0.05.
	Mixed	20.3% (14/69)	17.6% (9/51)	0.816^∂ ∂ p<0.05.
	Black	20.3% (14/69)	7.8% (4/51)	0.072^∂ ∂ p<0.05.
Type of delivery
	Vaginal	2.9% (2/69)	7.8% (4/51)	0.399^∂ ∂ p<0.05.
	Cesarean section	97.1% (67/69)	92.2% (47/51)	0.399^∂ ∂ p<0.05.
	Gestational age at delivery (weeks±SE)	37.8±0.38	37.69 ± 0.35	0.296^¥ ¥ Chi-squared: % (n/N)
	Obstetric and perinatal complications	43.5% (30/69)	35.3% (18/51)	0.366^∂ ∂ p<0.05.
	Birth weight (g±SE)	3182.68±98.73	3036.43 ± 92.33	0.836^¥ ¥ Chi-squared: % (n/N)
	Admission to neonatal ICU	8.7% (6/69)	2.0% (1/51)	0.120^∂ ∂ p<0.05.
	Maternal ICU admission	7.2% (5/69)	5.9% (3/51)	0.767^∂ ∂ p<0.05.

Obstetric and perinatal complications	Donated oocytes (N=69)	Own oocytes (N=51)	OR (95%CI)	aOR (95%CI)
Preeclampsia	17.4% (12/69)	15.5% (8/51)	1.32 (0.42–3.06), p>0.999	1.74 (0.53–5.65), p=0.357
Gestational diabetes mellitus	10.1% (7/69)	3.9% (2/51)	2.76 (0.56–13.55), p=0.298	3.51 (0.54–22.69), p=0.187
Premature rupture of ovular membranes	1.4% (1/69)	2.0% (1/51)	0.73 (0.03–14.23), p>0.999	0.00 (0.0-infinite), p=0.996
Uterine atony	1.4% (1/69)	2.0% (1/51)	0.73 (0.03–14.23), p>0.999	0.00 (0.0-infinite), p=0.996
Placenta previa	1.4% (1/69)	3.9% (2/51)	0.36 (0.02–3.19), p=0.574	0.22 (0.008–6.72), p=0.393
Breech presentation	1.4% (1/69)	0.0% (0/51)	^* * It was not possible to use a statistical test due to the absence of at least one case in each group. p<0.05.
Polycystic kidneys	1.4% (1/69)	0.0% (0/51)	^* * It was not possible to use a statistical test due to the absence of at least one case in each group. p<0.05.
Oligohydramnios	1.4% (1/69)	3.9% (2/51)	0.36 (0.02–3.19), p=0.574	0.22 (0.008–6.72), p=0.393
Gestational hypertension	1.4% (1/69)	3.9% (2/51)	0.36 (0.02–3.19), p=0.574	0.22 (0.008–6.72), p=0.393
Eclampsia	1.4% (1/69)	0.0% (0/51)	^* * It was not possible to use a statistical test due to the absence of at least one case in each group. p<0.05.
HELLP syndrome	0.0% (0/69)	0.0% (0/51)	^* * It was not possible to use a statistical test due to the absence of at least one case in each group. p<0.05.
Polyhydramnios	1.4% (1/69)	0.0% (0/51)	^* * It was not possible to use a statistical test due to the absence of at least one case in each group. p<0.05.
Chorioamnionitis	1.4% (1/69)	0.0% (0/51)	^* * It was not possible to use a statistical test due to the absence of at least one case in each group. p<0.05.
Respiratory distress	1.4% (1/69)	0.0% (0/51)	^* * It was not possible to use a statistical test due to the absence of at least one case in each group. p<0.05.

Associação Médica Brasileira R. São Carlos do Pinhal, 324, 01333-903 São Paulo SP - Brazil, Tel: +55 11 3178-6800, Fax: +55 11 3178-6816 - São Paulo - SP - Brazil
E-mail: ramb@amb.org.br

Acompanhe os números deste periódico no seu leitor de RSS

[1] *Corresponding author: araujojred@terra.com.br