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AMB Guidelines: COVID –19

The Guidelines Project, an initiative of the Brazilian Medical Association, aims to combine information from the medical field in order to standardize producers to assist the reasoning and decision-making of doctors.

The information provided through this project must be assessed and criticized by the physician responsible for the conduct that will be adopted, depending on the conditions and the clinical status of each patient.

The Brazilian Medical Association comprises various Specialty Societies, interacts with the Health System, public and private, municipal, state, and federal, and actively participates in the international scientific community through the World Medical Association and many other health institutions involved in education, assistance, or research.

These characteristics provide the AMB (board of director, scientific board, and departments) with unique and updated knowledge, a broad and concrete perspective of the facts as they are and not as we are, which along with our willingness to contribute to the national health system, allows our technical body to draw up recommendations that are autonomous, unbiased, transparent, and based on scientific evidence, mainly and including in emergency, conflict, and serious situations, as is the case with the Coronavirus (COVID-19).

Thinking of these recommendations from a practical point of view to aid in the decision-making by the Brazilian health system, these were divided into 4 main areas: 1. Know where the cases are (early diagnosis and prevalence of COVID-19 patients); 2. Directed hospital or home isolation (early diagnosis) and social isolation (to prevent spread by undiagnosed cases); 3. Protection of healthcare professionals (protect the health of professionals, maintain the workforce, and avoid dissemination by professionals); 4. Develop a health care structure capable of properly handling more severe cases that require hospitalization, particularly in Intensive Care Units (ICU).

The evidence used to support these recommendations is based on the mistakes and successes of the international community in the management of COVID-19 cases and on the assumption of its consequences on the control of the epidemiological spread, the reduction of mortality, and in fighting the course of the disease up until the year 2021.

The seven propositional elements in this assessment expressed in the following sequence support the recommendations. However, it is important to remember that they may suffer changes and incorporations as required by the evidence available and the national context, singe these are undergoing daily dynamic changes:

1. Know where the cases are (early diagnosis and prevalence of COVID-19 patients); 2. Directed hospital or home isolation (early diagnosis) and social isolation (to prevent spread by undiagnosed cases); 3. Protection of healthcare professionals (protect the health of professionals, maintain the workforce, and avoid dissemination by professionals); 4. Pre- and intra-hospital treatment; 5. Shared decision making; 6. Mental health; 7. A health care structure capable of properly handling more severe cases that require hospitalization, particularly in Intensive Care Units (ICU), maintaining proper assistance to non-COVID-19 patients.

Issues related to the return to common activities of everyday life, both of health care or community life, are not the scope of these recommendations given its current degree of uncertainty as measured by the indices of national viral circulation, as well as the different realities in several regions of the country.

RECOMMENDATIONS

The 10 recommendations deal with some of the best practices for diagnosis, treatment, prevention, and protection to the population, patients, doctors, and health professionals, in scenarios of unpredictability, uncertainty and that require rapid decision-making as in primary care, emergency or intensive care, or even in community environments or elective assistance in the care of patients with suspected or confirmed COVID-19, as well as in the general population or with other diseases:

  1. The Brazilian health system must adopt and maintain austere, intense and constant measures to minimize the effects that now affect the Brazilian population in the context of the worldwide COVID-19 epidemic (pandemic);

  2. Ensure hospital infrastructure with specific and isolated areas to care for suspected and sick patients, with specific hygiene and transport measures, and a guaranteed sufficient number of beds, particularly for critically ill patients in intensive care units associated with a sufficient number of respirators for respiratory care. Ensure the appropriate hospital care, thus minimizing the risk of contagion for non-COVID-19 patients11. Remuzzi A, Remuzzi G. COVID-19 and Italy: what next? Lancet 2020 Mar 13. pii: S0140-6736(20)30627-9. doi: 10.1016/S0140-6736(20)30627-9. PMID: 32178769.

    2. A Estratégia Sul-Coreana de Combate do Surto de COVID-19. Givisiez LGVB, Kim P, Gorito CAC. Páginas 1-9.

    3. Emanuel EJ, Persad G, Upshur R, Thome B, Parker M, Glickman A, et al. Fair Allocation of Scarce Medical Resources in the Time of COVID-19. N Engl J Med. 2020 Mar 23. doi: 10.1056/NEJMsb2005114. PMID: 32202722.

    4. Truog RD, Mitchell C, Daley GQ. The Toughest Triage - Allocating Ventilators in a Pandemic. N Engl J Med. 2020 Mar 23. doi: 10.1056/NEJMp2005689. PMID: 32202721.

    5. Estimativa da American Hospital Association sobre o impacto do Coronavírus no Sistema de Saúde dos EUA. Disponível em URL: https://www.businessinsider.com/presentation-us-hospitals-preparing-for-millions-of-hospitalizations-2020-3
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    6. Cenário dos hospitais o Brasil. Disponível em URL: http://fbh.com.br/wp-content/uploads/2019/05/CenarioDosHospitaisNoBrasil2019_10maio2019_web.pdf
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    - 77. Hospital beds (per 1,000 people). Disponível em URL: https://data.worldbank.org/indicator/SH.MED.BEDS.ZS
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  3. Constantly consider the index of system collapse (strain of the beds available, including ICU ones) in strategies for implementing additional beds to fill the gaps88. COVID-19 Projections – Institute for Health Metrics and Evaluation (IHME) – Disponível em URL: https://COVID-19.healthdata.org/projections. Acessado em 31 de março de 2020.
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    ;

  4. Ensure the provision and availability of protective equipment to health professionals, particularly those exposed to suspected or confirmed cases, with the following available for use during procedures: cap, mask (preferably N95), face shield, goggles, disposable and waterproof apron, and respirator99. The Lancet. COVID-19: protecting health-care workers. Lancet 2020; 395(10228):922. doi: 10.1016/S0140-6736(20)30644-9. PMID: 32199474.

    10. Coronavirus disease (COVID-19) outbreak: rights, roles and responsibilities of health workers, including key considerations for occupational safety and health. World Health Organization - Interim guidance 19 March 2020. Disponível em URL: https://www.who.int/docs/default-source/coronaviruse/who-rights-roles-respon-hw-COVID-19.pdf?sfvrsn=bcabd401_0. Acessado em 27 de março de 2020.
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    11. Advice on the use of masks in the community, during home care, and in health care settings in the context of COVID-19. World Health Organization - Interim guidance 19 March 2020. Disponível em URL: https://www.who.int/publications-detail/advice-on-the-use-of-masks-in-the-community-during-home-care-and-in-healthcare-settings-in-the-context-of-the-novel-coronavirus-(2019-ncov)-outbreak. Acessado em 27 03 2020.
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    12. Radonovich LJ Jr, Simberkoff MS, Bessesen MT, Brown AC, Cummings DAT, Gaydos CA, et al. N95 Respirators vs Medical Masks for Preventing Influenza Among Health Care Personnel: A Randomized Clinical Trial. JAMA. 2019; 322(9):824-833. doi: 10.1001/jama.2019.11645. PMID: 31479137.

    13. Rational use of personal protective equipment (PPE) for coronavirus disease (COVID-19). World Health Organization - Interim guidance 19 March 2020. Disponível em URL: https://apps.who.int/iris/handle/10665/331215. Acessado em 27 de março de 2020.
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    14. Schwartz J, King CC, Yen MY. Protecting Health Care Workers during the COVID-19 Coronavirus Outbreak -Lessons from Taiwan’s SARS response. Clin Infect Dis 2020. pii: ciaa255. doi: 10.1093/cid/ciaa255. PMID: 32166318.

    15. Yen MY, Schwartz J, Chen SY, King CC, Yang GY, Hsueh PR. Interrupting COVID-19 transmission by implementing enhanced traffic control bundling: Implications for global prevention and control efforts. J Microbiol Immunol Infect. 2020 Mar 14. pii: S1684-1182(20)30071-2. doi: 10.1016/j.jmii.2020.03.011. PMID: 32205090.

    16. Strategies to Optimize the Supply of PPE and Equipment. Centers for Disease Control and Prevention (CDC.gov). Coronavirus Disease 2019. Disponível em URL: https://www.cdc.gov/coronavirus/2019-ncov/hcp/ppe-strategy/index.html. Acessado em 27 de março de 2020.
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    17. Modes of transmission of virus causing COVID-19: implications for IPC precaution recommendations. World Health Organization. Scientific brief 27 March 2020. Disponível em URL: https://www.who.int/publications-detail/modes-of-transmission-of-virus-causing-COVID-19-implications-for-ipc-precaution-recommendations Acessado em 27 de março de 2020.
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    18. Parodi SM, Liu VX. From Containment to Mitigation of COVID-19 in the US. JAMA. 2020 Mar 13. doi: 10.1001/jama.2020.3882. PMID: 32167525. Table. Key Elements of a Proposed Plan for Coronavirus Disease 2019 Community Spread Mitigation in Kaiser Permanente Northern California.

    19. Adams JG, Walls RM. Supporting the Health Care Workforce During the COVID-19 Global Epidemic. JAMA. 2020 Mar 12. doi: 10.1001/jama.2020.3972. PMID: 32163102.

    20. Infection prevention and control during health care when COVID-19 is suspected. World Health Organization. Interim guidance 19 March 2020. Disponível em URL: https://reliefweb.int/report/world/infection-prevention-and-control-during-health-care-when-COVID-19-suspected-interim. Acessado em 27 de março de 2020.
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    21. The burning building. BMJ 2020;368:m1101 doi: 10.1136/bmj.m1101 (Published 19 March 2020). Disponível em URL: https://www.bmj.com/content/bmj/368/bmj.m1101.full.pdf.
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    22. COVID-19 Coronavirus Pandemic (Update live): Disponível em URL: https://www.worldometers.info/coronavirus/. Acessado em: 22.04.2020.
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  5. Actively test patients with suspected COVID-19 by PCR, as well as those close to them who could have been contaminated, isolating (block) and monitoring confirmed patients, whenever possible in a community environment or through hospitalization; community isolation (lockdown) proportional to the mortality and/or number of cases diagnosed in the area, particularly of patients in risk groups2424. Sharfstein JM, Becker SJ, Mello MM. Diagnostic Testing for the Novel Coronavirus. JAMA. 2020 Mar 9. doi: 10.1001/jama.2020.3864. PMID: 32150622.

    25. Loeffelholz MJ, Tang YW. Laboratory Diagnosis of Emerging Human Coronavirus Infections - The State of the Art. Emerg Microbes Infect 2020; 20:1-26. doi: 10.1080/22221751.2020.1745095. PMID: 32196430.

    26. Pfefferle S, Reucher S, Nörz D, Lütgehetmann M. Evaluation of a quantitative RT-PCR assay for the detection of the emerging coronavirus SARS-CoV-2 using a high throughput system. Euro Surveill 2020; 25. doi: 10.2807/1560-7917.ES.2020.25.9.2000152. PMID: 32156329.

    27. Corman VM, Landt O, Kaiser M, Molenkamp R, Meijer A, Chu DKW, et al. Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR. Euro Surveill 2020; 25(3). doi: 10.2807/1560-7917.ES.2020.25.3.2000045. PMID: 31992387.

    28. Reusken CBEM, Broberg EK, Haagmans B, Meijer A, Corman VM, et al. Laboratory readiness and response for novel coronavirus (2019-nCoV) in expert laboratories in 30 EU/EEA countries, January 2020. Euro Surveill 2020; 25. doi: 10.2807/1560-7917.ES.2020.25.6.2000082. PMID: 32046815.

    29. Cohen J, Kupferschmidt K. Countries test tactics in ‘war’ against COVID-19. Science 2020; 367(6484):1287-1288. doi: 10.1126/science.367.6484.1287. PMID: 32193299.

    30. Guo L, Ren L, Yang S, Xiao M, Chang, Yang F, et al. Profiling Early Humoral Response to Diagnose Novel Coronavirus Disease (COVID-19). Clin Infect Dis 2020. pii: ciaa310. doi: 10.1093/cid/ciaa310. PMID: 32198501.

    31. Konrad R, Eberle U, Dangel A, Treis B, Berger A, Bengs K, et al. Rapid establishment of laboratory diagnostics for the novel coronavirus SARS-CoV-2 in Bavaria, Germany, February 2020. Euro Surveill 2020; 25(9). doi: 10.2807/1560-7917.ES.2020.25.9.2000173. PMID: 32156330.

    32. Onder G, Rezza G, Brusaferro S. Case-Fatality Rate and Characteristics of Patients Dying in Relation to COVID-19 in Italy. JAMA 2020 Mar 23. doi: 10.1001/jama.2020.4683. PMID: 32203977.

    33. Spiteri G, Fielding J, Diercke M, Campese C, Enouf V, Gaymard A, et al. First cases of coronavirus disease 2019 (COVID-19) in the WHO European Region, 24 January to 21 February 2020. Euro Surveill 2020; 25(9). doi: 10.2807/1560-7917.ES.2020.25.9.2000178. PMID: 32156327.

    34. Zhao S, Lin Q, Ran J, Musa SS, Yang G, Wang W, et al. Preliminary estimation of the basic reproduction number of novel coronavirus (2019-nCoV) in China, from 2019 to 2020: A data-driven analysis in the early phase of the outbreak. Int J Infect Dis. 2020 Mar; 92:214-217. doi: 10.1016/j.ijid.2020.01.050. PMID: 32007643.

    35. Salathé M, Althaus CL, Neher R, Stringhini S, Hodcroft E, Fellay J, et al. COVID-19 epidemic in Switzerland: on the importance of testing, contact tracing and isolation. Swiss Med Wkly. 2020; 150: w20225. doi: 10.4414/smw.2020.20225. PMID: 32191813.

    36. Wang CJ, Ng CY, Brook RH. Response to COVID-19 in Taiwan: Big Data Analytics, New Technology, and Proactive Testing. JAMA 2020 Mar 3. doi: 10.1001/jama.2020.3151. PMID: 32125371.

    37. Prioridades para realização de testes em pacientes com suspeitas de COVID- 19. Disponível em URL: https://www.cdc.gov/coronavirus/2019-ncov/downloads/priority-testing-patients.pdf.
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    38. The Global Impact of COVID-19 and Strategies for Mitigation and Suppression. Imperial College COVID-19 Response Team. 26 March 2020. Disponível em URL: https://www.imperial.ac.uk/media/imperial-college/medicine/sph/ide/gida-fellowships/Imperial-College-COVID-19-Global-Impact-26-03-2020.pdf. Acessado em 27 de março de 2020.
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    39. Impact of non-pharmaceutical interventions (NPIs) to reduce COVID-19 mortality and healthcare demand. Imperial College COVID-19 Response Team. 16 March 2020. Disponível em URL: https://www.imperial.ac.uk/media/imperial-college/medicine/sph/ide/gida-fellowships/Imperial-College-COVID-19-NPI-modelling-16-03-2020.pdf. Acessado em 27 de março de 2020.
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  6. Organize multi-professional committees to discuss the care priorities and community strategies according to scientific and ethical criteria to assist in decision-making in the context of the national epidemic;

  7. There is no evidence to support the use of any pre-hospital treatment, both as a prophylactic (to reduce the incidence of new cases) or in suspected or confirmed cases (to reduce mortality) 4141. Siemieniuk RA, Bartoszko JJ, Ge L, Zeraatkar D, Izcovich A, Pardo-Hernandez H, et al. Drug treatments for COVID-19: living systematic review and network meta-analysis. BMJ. 2020 Jul 30;370:m2980. doi: 10.1136/bmj.m2980. PMID: 32732190; PMCID: PMC7390912.

    42. Borba MGS, Val FFA, Sampaio VS, Alexandre MAA, Melo GC, Brito M, et al. Effect of High vs Low Doses of Chloroquine Diphosphate as Adjunctive Therapy for Patients Hospitalized With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection: A Randomized Clinical Trial. JAMA Netw Open 2020; 3(4):e208857. doi:10.1001/jamanetworkopen.2020.8857. PMID: 32330277.

    43. Boulware DR, Pullen MF, Bangdiwala AS, Pastick KA, Lofgren SM, Okafor EC, et al. A Randomized Trial of Hydroxychloroquine as Postexposure Prophylaxis for COVID-19. N Engl J Med 2020: NEJMoa2016638. doi: 10.1056/NEJMoa2016638. PMID: 32492293.

    44. Chen L, Zhang ZY, Fu JG, Feng ZP, Zhang SZ, Han QY, et al. Efficacy and safety of chloroquine or hydroxychloroquine in moderate type of COVID-19: a prospective open-label randomized controlled study. Disponível em: medRxiv preprint doi: https://doi.org/10.1101/2020.06.19.20136093.this version posted June 22, 2020.
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    45. Chen Z, Hu J, Zhang Z, Jiang S, Han S, Dandan Y, et al. Efficacy of hydroxychloroquine in patients with COVID-19: results of a randomized clinical trial. Disponível em: medRxiv preprint doi: https://doi.org/10.1101/2020.03.22.20040758.this version posted April 10, 2020.
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    46. Jun C, Danping L, Li L, Ping L, Qingnian X, Lu X, et al. A pilot study of hydroxychloroquine in treatment of patients with common coronavirus disease-19 (COVID-19). Journal of the University of Zhejiang 2020; 49 (2): 215-19. DOI: 10.3785/j.issn.1008-9292.2020.03.03.

    47. Tang W, Cao Z, Han M, Wang Z, Chen J, Sun W, et al. Hydroxychloroquine in patients with mainly mild to moderate coronavirus disease 2019: open label, randomised controlled trial. BMJ 2020; 369:m1849. doi: 10.1136/bmj.m1849. PMID: 32409561.

    48. Horby P and Landray M. Statement from the Chief Investigators of the Randomised Evaluation of COVid-19 thERapY (RECOVERY) Trial on hydroxychloroquine, 5 June 2020. Disponível em: https://www.recoverytrial.net/files/hcq-recovery-statement-050620-final-002.pdf
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    49. Interrupção precoce do braço de HCQ no estudo “Solidarity” da OMS. Disponível em: https://www.who.int/news-room/detail/04-07-2020-who-discontinues-hydroxychloroquine-and-lopinavir-ritonavir-treatment-arms-for-COVID-19.
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  8. The use of dexamethasone in hospitalized patients who require oxygen supplementation seems to reduce mortality5151. RECOVERY Collaborative Group, Horby P, Lim WS, Emberson JR, Mafham M, Bell JL, Linsell L, et al. Dexamethasone in Hospitalized Patients with COVID-19 - Preliminary Report. N Engl J Med. 2020 Jul 17. doi: 10.1056/NEJMoa2021436. Epub ahead of print. PMID: 32678530. ;

  9. Provide emotional support for healthcare professionals and patients, as necessary and as symptoms of psychological/psychiatric nature are identified5252. Lai J, Ma S, Wang Y, Cai Z, Hu J, Wei N, et al. Factors Associated with Mental Health Outcomes Among Health Care Workers Exposed to Coronavirus Disease. 2019. JAMA Netw Open 2020; 3: e 203976. doi:10.1001/jamanetworkopen.2020.3976. PMID: 32202646.

    53. Xiao H, Zhang Y, Kong D, Li S, Yang N. Social Capital and Sleep Quality in Individuals Who Self-Isolated for 14 Days During the Coronavirus Disease 2019 (COVID-19) Outbreak in January 2020 in China. Med Sci Monit 2020; 26: e 923921. doi: 10.12659/MSM.923921. PMID: 32194290.

    54. Brooks SK, Webster RK, Smith LE, Woodland L, Wessely S, Greenberg N, et al. The psychological impact of quarantine and how to reduce it: rapid review of the evidence. Lancet 2020; 395: 912-920. doi: 10.1016/S0140-6736(20)30460-8. PMID: 32112714.

    55. Depression and Other Common Mental Disorders: Global Health Estimates. Geneva: World Health Organization; 2017. Licence: CC BY-NC-SA 3.0 IGO.

    56. Estimated DALYs, YLL and YLD (‘000) by cause, sex and WHO Member State (1), 2016. World Health Organization. Department of Information, Evidence and Research. June 2018. Disponível em: https://www.who.int/healthinfo/globalburden_disease/estimates/en/index1.html. Acessado em 09 de abril de 2020.
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    57. Yao H, Chen JH, Xu YF. Patients with mental health disorders in the COVID-19 epidemic. Lancet Psychiatry 2020; 7: e21. doi: 10.1016/S2215-0366(20)30090-0. PMID: 32199510.

    58. Wang C, Pan R, Wan X, Tan Y, Xu L, Ho CS, et al. Immediate Psychological Responses and Associated Factors during the Initial Stage of the 2019 Coronavirus Disease (COVID-19) Epidemic among the General Population in China. Int J Environ Res Public Health 2020; 17. pii: E1729. doi: 10.3390/ijerph17051729. PMID: 32155789.

    59. Li W, Yang Y, Liu ZH, Zhao YJ, Zhang Q, Zhang L, et al. Progression of Mental Health Services during the COVID-19 Outbreak in China. Int J Biol Sci 2020; 16: 1732-1738. doi: 10.7150/ijbs.45120. PMID: 32226291.

    60. Yang Y, Li W, Zhang Q, Zhang L, Cheung T, Xiang YT. Mental health services for older adults in China during the COVID-19 outbreak. Lancet Psychiatry 2020; 7: e19. doi: 10.1016/S2215-0366(20)30079-1. PMID: 32085843.

    61. Bo HX, Li W, Yang Y, Wang Y, Zhang Q, Cheung T, et al. Posttraumatic stress symptoms and attitude toward crisis mental health services among clinically stable patients with COVID-19 in China. Psychol Med 2020; 27:1-7. doi: 10.1017/S0033291720000999. PMID: 32216863.

    62. Qiu J, Shen B, Zhao M, Wang Z, Xie B, Xu Y. A nationwide survey of psychological distress among Chinese people in the COVID-19 epidemic: implications and policy recommendations. Gen Psychiatr 2020; 33: e100213.doi: 10.1136/gpsych-2020-100213. PMID: 32215365.
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  10. The decisions between doctor and patient must follow the principles of shared decision-making, in which the patient is adequately informed of the benefits or absence of benefits, as well as the risks, to actively participate in the medical decision6464. Hoffmann TC; Del Mar C. Patients’ Expectations of the Benefits and Harms of Treatments, Screening, and Tests. A Systematic Review. JAMA Intern Med 2015;175(2):274-286.

    65. Coylewright M, Montori V, Ting HH. Patient-centered Shared Decision-making: A Public Imperative. The American Journal of Medicine, Vol 125, No 6, June 2012.

    66. Bouma AB, Tiedje K, Poplau S, Boehm DH, Shah ND, Commers MJ, et al. Shared decision making in the safety net: where do we go from here? J Am Board Fam Med. 2014 Mar-Apr;27(2):292-4. doi: 10.3122/jabfm.2014.02.130245. PMID: 24610192.

    67. Kuppermann M, Sawaya GF. Shared Decision-Making. Easy to Evoke, Challenging to Implement. JAMA Internal Medicine February 2015 Volume 175, Number 2.

    68. Gulbrandsen P. What’s in shared decision-making for the physician? Patient Education and Counseling 97 (2014) 145–6.

    69. Hoffmann TC, Del Mar CB. Shared decision making: what do clinicians need to know and why should they bother? Med J Aust. 2014 Nov 3;201(9):513-4. doi: 10.5694/mja14.01124. PMID: 25358570.

    70. Bot AG, Bossen JK, Herndon JH, Ruchelsman DE, Ring D, Vranceanu AM. Informed shared decision-making and patient satisfaction. Psychosomatics. 2014 Nov-Dec; 55(6):586-94. doi: 10.1016/j.psym.2013.12.013. Epub 2014 Jan 3. PMID: 24836165.

    71. Durand MA, Moulton B, Cockle E, Mann M, Elwyn G. Can shared decision-making reduce medical malpractice litigation? A systematic review. BMC Health Serv Res. 2015 Apr 18; 15:167. doi: 10.1186/s12913-015-0823-2. PMID: 25927953; PMCID: PMC4409730.

    72. Légaré F, Thompson-Leduc P. Twelve myths about shared decision making. Patient Educ Couns. 2014 Sep;96(3):281-6. doi: 10.1016/j.pec.2014.06.014. Epub 2014 Jul 3. PMID: 25034637.

    73. Epstein RM, Gramling RE. What is shared in shared decision making? Complex decisions when the evidence is unclear. Med Care Res Rev. 2013 Feb;70(1 Suppl):94S-112S. doi: 10.1177/1077558712459216. Epub 2012 Oct 2. PMID: 23035055.

    74. Elwyn G, Fisher E. Higher integrity health care: evidence-based shared decision making. Circ Cardiovasc Qual Outcomes. 2014 Nov;7(6):975-80. doi: 10.1161/CIRCOUTCOMES.114.000688. Epub 2014 Sep 30. PMID: 25271048.
    - 7575. Elwyn G, Frosch D, Thomson R, Joseph-Williams N, Lloyd A, Kinnersley P, et al. Shared decision making: a model for clinical practice. J Gen Intern Med. 2012 Oct;27(10):1361-7. doi: 10.1007/s11606-012-2077-6. Epub 2012 May 23. PMID: 22618581; PMCID: PMC3445676. . In addition, the AMB stands firmly in favor of the autonomy of doctors and patients, under the terms of the Helsinki Declaration, of which we are signatory7676. WMA declaration of Helsinki – ethical principles for medical research involving human subjects. Disponível em: https://www.wma.net/policies-post/wma-declaration-of-helsinki-ethical-principles-for-medical-research-involving-human-subjects/
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    .

Acknowledgments

Luca Bernardo, Filipe Bernardo, and Fernanda Bley for aiding in the search and selection of evidence and drafting.

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Publication Dates

  • Publication in this collection
    21 Sept 2020
  • Date of issue
    2020

History

  • Received
    July 2020
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