Assessment of neutrophil and neutrophil/lymphocyte ratio in coronary collateral developed patients with acute coronary syndrome

Mansiroglu, Asli Kurtar; Sincer, Isa; Gunes, Yilmaz

doi:10.1590/1806-9282.66.7.954

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Sumário

ORIGINAL ARTICLE • Rev. Assoc. Med. Bras. 66 (7) • July 2020 • https://doi.org/10.1590/1806-9282.66.7.954 copy

Assessment of neutrophil and neutrophil/lymphocyte ratio in coronary collateral developed patients with acute coronary syndrome

Authorship SCIMAGO INSTITUTIONS RANKINGS

SUMMARY

OBJECTIVE

Inflammation-related markers provide diagnostic and prognostic information for coronary artery disease and acute coronary syndrome. We aimed to compare neutrophil count and neutrophil/lymphocyte ratio (NLR) in acute coronary syndrome patients with coronary collateral development in our study.

METHODS

A total of 426 patients (102 unstable angina pectoris (USAP), 223 non-ST-elevation myocardial infarction (non-STEMI), 103 ST-elevation myocardial infarction (STEMI) were compared regarding hemoglobin, platelet, lymphocyte, neutrophil count, and NLR.

RESULTS

Neutrophil count and NLR were significantly lower in USAP patients and higher in STEMI patients; 5.14± 1.79 vs. 7.21± 3.05 vs. 9.93±4.67 and 2.92±2.39 vs. 5.19±4.80 vs. 7.93±6.38, p <0.001. Other parameters, i.e., hemoglobin, platelet, and lymphocyte count, were not significantly different between the groups.

CONCLUSIONS

In our study, it was concluded that there may be a statistically significant difference in the number of neutrophil counts and NLR among the types of acute coronary syndromes with coronary collateral development.

Acute coronary syndrome; Collateral circulation; Neutrophils; Lymphocytes

Baseline characteristics	USAP ( n=102)	Non-STEMI (n=221)	STEMI (n=103)	p
	MEAN
Age (mean ±SD) (years)	64 ±12	67±12	67±13	0.11
Body mass index (kg/m²)	25±4	26 ± 4	25±3	0.43
Male/female	79/23	146/75	76/27	0.08
Hypertension (%)	67(65%)	139(63%)	53(51%)	0.07
Smoking(%)	42(41%)	81(37%)	35(34%)	0.56
Family history(%)	16(16%)	26(12%)	(88%)	0.21
Diabetes mellitus(%)	39(38%)	83(37%)	27(26%)	0.10
Acetylsalicylate (%)	35(34%)	70(32%)	29(28%)	0.63
Clopidogrel(%)	17(17%)	25(11%)	13(12%)	0.41
Statin(%)	25(24%)	46(21%)	13(13%)	0.08
Calcium channel blocker(%)	15(14%)	44(20%)	12(12%)	0.15
ACE inhibitor(%)	27(26%)	41(19%)	14(14%)	0.06
ARB (%)	21(21%)	36(16%)	18(17%)	0.64
Beta-blocker(%)	38(37%)	63(28%)	30(29%)	0.26

	USAP (n=102)	Non-STEMI (n=221)	STEMI (n=103)	p
	MEAN
Creatinine (mg/dl)	1.0±0.3	1.0 ± 0.8	1.0± 0.3	0.50
Fasting plasma glucose (mg/dl)	130±42	138 ± 50	139±50	0.32
LDL-cholesterol (mg/dl)	113±44	115±41	118± 44	0.68
HDL-cholesterol (mg/dl)	42±9	45±11	43± 10	0.12
Triglyceride (mg/dl)	159±91	151± 92	157±102	0.76
Total cholesterol (mg/dl)	185±49	189±49	191± 51	0.74
Hemoglobin	13.6±1.6	13.5± 2.0	13.6± 1.9	0.84
Platelet counts (k/mm³)	224±71	235±67	237±72	0.29
Lymphocyte (u/mm³)	2.18±0.90	1.92±1.09	1.76±1.05	0.013*
Neutropil(u/mm³)	5.14± 1.79	7.21± 3.05	9.93±4.67	<0.001*
NLR	2.92±2.39	5.19±4.80	7.93±6.38	<0.001*

Coronary artery	USAP (n=102)	Non-STEMI (n=221)	STEMI (n=103)	p
LMCA	12(12%)	18(8%)	8(8%)	0.098
LAD	86(84%)	193(87%)	90(87%)	0.281
CX	62(60%)	158(71%)	77(75%)	0.305
RCA	91(91%)	195(88%)	96(93%)	0.015

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[1] CORRESPONDING AUTHOR: Asli Kurtar Mansiroglu Abant Izzet Baysal University Hospital, Department of Cardiology, Golkoy, Bolu, Turkey – 14280 Tel: +90 374 253-4656 / Fax: +90 374 253-4615 E-mail: dr.asli.kurtar@gmail.com