Morse et al., 2015 88. Morse CG, McLaughlin M, Matthews L, Proschan M, Thomas F, Gharib AM, et al. Nonalcoholic steatohepatitis and hepatic fibrosis in HIV-1-monoinfected adults with elevated aminotransferase levels on antiretroviral therapy. Clin Infect Dis. 2015;60(10):1569-78.
|
USA |
Biopsy |
62 |
IR/DM (+); Hepatic steatosis (+); Aminotransferases elevation (+); Polymorphyms PNPLA3. |
Vodkin et al., 2015 22. Vodkin I, Valasek MA, Bettencourt R, Cachay E, Loomba R. Clinical, biochemical and histological differences between HIV- associated NAFLD and primary NAFLD: a case-control study. Aliment Pharmacol Ther. 2015;41(4):368-78.
|
USA |
Biopsy |
86 |
Dyslipidemia (+); aminotransferases elevation (+); Canalicular enzymes (+); ART (-); HIV (+) |
Nishijima et al., 2014 1515. Nishijima T, Gatanaga H, Shimbo T, Komatsu H, Nozaki Y, Nagata N, et al. Traditional but not HIV-related factors are associated with nonalcoholic fatty liver disease in Asian patients with HIV-1 infection. PLoS One. 2014;9(1):e87596.
|
Japan |
Ultrasonography |
485 |
IR/DM (-); BMI/WC (+); Dyslipidemia (+), hypertriglyceridemia and elevated LDL levels; aminotransferases elevation (+), elevated ALT; ART (-);Elevated CD4+ (+) |
Price et al., 2014 1919. Price JC, Seaberg EC, Latanich R, Budoff MJ, Kingsley LA, Palella FJ Jr, et al. Risk factors for fatty liver in the Multicenter AIDS Cohort Study. Am J Gastroenterol. 2014;109(5):695-704.
|
USA |
Computer Tomography |
719 |
IR/DM (+); BMI/WC (+); Elevation of aminotransferases (+), elevated ALT; ART (+), greater cumulative exposure to Dideoxynucleoside analogues (Stavudina, Didanosine, Zalcitabine); HIV (-); CD4+ (-) |
Rivero-Juarez et al., 2013 1717. Rivero-Juárez A, Camacho A, Merchante N, Pérez-Camacho I, Macias J, Ortiz-Garcia C, et al; Grupo para el estudio de las hepatitis vı´ricas (HEPAVIR) de la Sociedad Andaluza de Enfermedades Infecciosas (SAEI). Incidence of liver damage of uncertain origin in HIV patients not co-infected with HCV/HBV. PLoS One. 2013;8(7):e68953.
|
Spain |
Biopsy |
10 |
IR/DM (+); BMI/WC (+); Dyslipidemia (+), hypertriglyceridemia; Hepatic steatosis (+); ART (-); CD4+ plus hypertriglyceridemia (+) |
Sterling et al., 2013 99. Sterling RK, Smith PG, Brunt EM. Hepatic steatosis in human immunodeficiency virus: a prospective study in patients without viral hepatitis, diabetes, or alcohol abuse. J Clin Gastroenterol. 2013;47(2):182-7.
|
USA |
Biopsy |
14 |
IR/DM (+); Canalicular enzymes (+) plus hypertriglyceridemia |
Crum-Cianflone et al., 2009 1111. Crum-Cianflone N, Dilay A, Collins G, Asher D, Campin R, Medina S, et al. Nonalcoholic fatty liver disease among HIV-infected persons. J Acquir Immune Defic Syndr. 2009;50(5):464-73.
|
USA |
Ultrasonography |
216 |
BMI/WC plus Hypertriglyceridemia (+); Dyslipidemia (+), hypertriglyceridemia and decreased HDL levels; ART (-); HIV (-); CD4+ (-) |
Ingiliz et al., 2009 1818. Ingiliz P, Valantin MA, Duvivier C, Medja F, Dominguez S, Charlotte F, et al. Liver damage underlying unexplained transaminase elevation in human immunodeficiency virus-1 mono-infected patients on antiretroviral therapy. Hepatology. 2009;49(2):436-42.
|
France |
Biopsy |
30 |
IR/DM (+); BMI/WC (-); Dyslipidemia (-); ART (-); HIV (-) |
Akhtar et al., 2008 1212. Akhtar MA, Mathieson K, Arey B, Post J, Prevette R, Hillier A, et al. Hepatic histopathology and clinical characteristics associated with antiretroviral therapy in HIV patients without viral hepatitis. Eur J Gastroenterol Hepatol. 2008;20(12):1194-204.
|
USA |
Biopsy |
23 |
BMI/WC (+); ART (+), all patients who presented DHGNA were exposed to NRTIs; HIV (+) |
Guaraldi et al., 2008 1616. Guaraldi G, Squillace N, Stentarelli C, Orlando G, D’Amico R, Ligabue G, et al. Nonalcoholic fatty liver disease in HIV-infected patients referred to a metabolic clinic: prevalence, characteristics, and predictors. Clin Infect Dis. 2008;47(2):250-7.
|
Italy |
Computer Tomography |
225 |
IR/DM (+); BMI/WC and Visceral Adipose Tissue (+); Dyslipidemia (+); aminotransferases elevation (+); ART (+), exposure to NRTIs |
Mohammed et al., 2007 1313. Mohammed SS, Aghdassi E, Salit IE, Avand G, Sherman M, Guindi M, et al. HIV-positive patients with nonalcoholic fatty liver disease have a lower body mass index and are more physically active than HIV-negative patients. J Acquir Immune Defic Syndr. 2007;45(4):432-8.
|
Canada |
Biopsy |
26 |
BMI/WC (-); Dyslipidemia (+), hypertriglyceridemia; |