Bryan & Kohler 19742424. Bryan EM, Kohler HG. The missing umbilical artery. I. Prospective
study based on a maternity unit. Arch Dis Child. 1974;49(11):844-52.
|
prospective |
113 |
PN examination |
<10th centile |
22.1 |
NS |
Heifetz 198444. Heifetz SA. Single umbilical artery. A statistical analysis of 237
autopsy cases and review of the literature. Perspect Pediatr Pathol.
1984;8(4):345-78.
|
Retrospective case-control |
69 |
Autopsy |
SGA |
43.5 versus 23.8 (p<0.01) |
NS |
Lilja 199155. Lilja M. Infants with single umbilical artery studied in a national
registry. General epidemiological characteristics. Paediatr Perinat Epidemiol.
1991;5(1):27-36.
|
Retrospective case-control |
1674 |
PN examination |
<2500g |
11.4 versus 3.6 (p <0.0001) |
NS |
Jones et al. 199366. Jones TB, Sorokin Y, Bhatia R, Zador IE, Bottoms SF. Single umbilical
artery: accurate diagnosis? Am J Obstet Gynecol. 1993;169(3):538-40.
|
Retrospective case-control |
37 |
US + PN confirmation |
Birth weight |
2750 g versus 3170 g (p<0.01) |
NS |
Catanzarite et al. 19952020. Catanzarite VA, Hendricks SK, Maida C, Westbrook C, Cousins L,
Schrimmer D. Prenatal diagnosis of the two-vessel cord: implications for patient
counselling and obstetric management. Ultrasound Obstet Gynecol.
1995;5(2):98-105.
|
Retrospective |
38 |
US + PN confirmation |
<10th centile |
18.0 |
Yes |
Parilla et al. 19952121. Parilla BV, Tamura RK, MacGregor SN, Geibel LJ, Sabbagha RE. The
clinical significance of a single umbilical artery as an isolated finding on prenatal
ultrasound. Obstet Gynecol. 1995;85(4):570-2.
|
Retrospective |
50 |
US + PN confirmation |
<2500g |
12.0 |
No |
Geipel et al. 20002222. Geipel A, Germer U, Welp T, Schwinger E, Gembruch U. Prenatal
diagnosis of single umbilical artery: determination of the absent side, associated
anomalies, Doppler findings and perinatal outcome. Ultrasound Obstet Gynecol.
2000;15(2):114-7.
|
Retrospective |
59 |
US + PN confirmation |
<10th centile |
10.2 |
NS |
Rinehart et al. 20002323. Rinehart BK, Terrone DA, Taylor CW, Isler CM, Larmon JE, Roberts WE.
Single umbilical artery is associated with an increased incidence of structural and
chromosomal anomalies and growth restriction. Am J Perinatol.
2000;17(5):229-32.
|
Retrospective |
6 |
US |
NS |
50.0 |
Yes |
Gornall et al. 200377. Gornall AS, Kurinczuk JJ, Konje JC. Antenatal detection of a single
umbilical artery: does it matter? Prenat Diagn. 2003;23(2):117-23.
|
Retrospective case-control |
83 |
US + PN confirmation |
<10th centile |
22.0 versus 12.0 (p <0.007) |
Yes |
Predanic et al. 20051313. Predanic M, Perni SC, Friedman A, Chervenak FA, Chasen ST. Fetal
growth assessment and neonatal birth weight in fetuses with an isolated single
umbilical artery. Obstet Gynecol. 2005;105(5 Pt 1):1093-7.
|
Retrospective case-control |
84 |
US + PN confirmation |
<10th centile |
7.1 versus 4.8 (p= 0.75) |
No |
Mu et al. 200888. Mu SC, Lin CH, Chen YL, Sung TC, Bai CH, Jow GM. The perinatal
outcomes of asymptomatic isolated single umbilical artery in full-term neonates.
Pediatr Neonatol. 2008;49(6):230-3.
|
Retrospective case-control |
14 |
PN |
<10th centile |
35.7 versus 3.6 (p= 0.01) |
Yes |
Bombrys et al. 20081414. Bombrys AE, Neiger R, Hawkins S, Sonek J, Croom C, McKenna D, et al.
Pregnancy outcome in isolated single umbilical artery. Am J Perinatol.
2008;25(4):239-42.
|
Retrospective case-control |
255 |
US + PN confirmation |
<10th centile |
13.7 versus 13.1 (p- 0.84) |
No |
Burshtein et al. 200999. Burshtein S, Levy A, Holcberg G, Zlotnik A, Sheiner E. Is single
umbilical artery an independent risk factor for perinatal mortality? Arch Gynecol
Obstet. 2011;283(2):191-4.
|
Retrospective population based |
243 |
PN |
NS |
9.5 versus 1.9 (p <0.001) OR 5.4 (95% CI 3.5-8.4) |
Yes |
Bugatto et al. 20101818. Bugatto F, Quintero-Prado R, Melero-Jiménez V, Fajardo-Expósito MA,
Hervías-Vivancos B, Bartha JL. Ultrasound predictors of birth weight in euploid
fetuses with isolated single umbilical artery. Ultrasound Obstet Gynecol.
2010;36(6):724-7.
|
NS |
60 |
US + PN confirmation |
<10th centile |
30.0 |
Yes |
Chetty-John et al. 20101010. Chetty-John S, Zhang J, Chen Z, Albert P, Sun L, Klebanoff M, et al.
Longterm physical and neurologic development in newborn infants with isolated single
umbilical artery. Am J Obstet Gynecol. 2010;203(4):368.e1-7.
|
Prospective cohort |
263 |
PN |
birth weight |
3.1 kg versus 3.2 kg (p <0.0001) |
NS |
Horton et al. 20101515. Horton AL, Barroilhet L, Wolfe HM. Perinatal outcomes in isolated
single umbilical artery. Am J Perinatol. 2010;27(4):321-4.
|
Retrospective case-control |
68 |
US + PN confirmation |
<10th centile |
17.6 versus 8.8 (p- 0.06) |
Yes |
Hua et al. 20101111. Hua M, Odibo AO, Macones GA, Roehl KA, Crane JP, Cahill AG. Single
umbilical artery and its associated findings. Obstet Gynecol.
2010;115(5):930-4.
|
Retrospective cohort |
281 |
US + PN confirmation |
<10th centile |
OR 1.9 (95% CI: 1.4 - 2.5) |
Yes |
Murphy-Kaulbeck et al. 20101212. Murphy-Kaulbeck L, Dodds L, Joseph KS, Van den Hof M. Single
umbilical artery risk factors and pregnancy outcomes. Obstet Gynecol.
2010;116(4):843-50.
|
Retrospective population based-cohort |
725 |
PN |
<3rd centile |
11.1 versus 3.7 OR 2.5 (95% CI 1.9-3.2) |
Yes |
<10th centile |
25.0 versus 10.9 OR 2.2 (95% CI 1.8-2.7) |
Present study |
Retrospective cases and prospective controls |
131 |
US + PN confirmation |
<5th centile |
21.4 versus 13.6 (p-0.03) |
Yes (high-risk pregnancies only) |
<10th centile |
30.5 versus 23.2 (p-0.06) |