Vitamin D levels in patients with seborrheic dermatitis

Akbaş, Ayşe; Kılınç, Fadime; Şener, Sertaç; Hayran, Yıldız

doi:10.1590/1806-9282.20230022

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Revista da Associação Médica Brasileira

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ORIGINAL ARTICLE • Rev. Assoc. Med. Bras. 69 (7) • 2023 • https://doi.org/10.1590/1806-9282.20230022 copy

Vitamin D levels in patients with seborrheic dermatitis

Authorship SCIMAGO INSTITUTIONS RANKINGS

SUMMARY

OBJECTIVE:

Seborrheic dermatitis is a common papulosquamous skin disease with unknown pathogenesis. The aim of our study was to determine the serum level of 25-hydroxy vitamin D in patients with seborrheic dermatitis SD.

METHODS:

A total of 53 patients and 60 healthy controls were included in the study. Serum vitamin D, calcium, phosphorus, and parathormone levels were measured in the patient and control groups, and a comparison was made between the two groups regarding these parameters.

RESULTS:

Severe vitamin D deficiency was more frequent among patients with seborrheic dermatitisSD compared to controls (52.8 vs. 25.8%, p=0.003). In patients with severe vitamin D deficiency, seborrheic dermatitis SD was detected more frequently at an early age (p=0048) and in women (p=0.015). No correlation was found between the seborrheic dermatitis skin involvement site and vitamin D level.

CONCLUSION:

The fact that vitamin D levels decreased in patients with seborrheic dermatitis SD and patients with severe vitamin D deficiency develop seborrheic dermatitis SD earlier suggests that the low levels of vitamin D are related to seborrheic dermatitis.

Keywords
Seborrheic dermatitis; Vitamin D; Calcium; Phosphorus; Parathormone

	Patients with severe vit D deficiency	Patients without severe vit D deficiency	p-value
Age, average (standard deviation)	28.9 (9.7)	35.2 (13.1)	0.048
Sex, n (%)
Female	16 (57.1)	6 (24)	0.015
Male	12 (42.9)	19 (76)	0.015
Disease duration, years, median (IQR)	3 (1–5)	3 (1.7–8.5)	0.34
Age of onset, median (IQR)	23 (18.9–28.4)	26 (22–34.5)	0.14
Number of sites involved, median (IQR)	1.5 (1–3.8)	2 (1–2.5)	0.85
Scalp involvement, n (%)
Yes	26 (92.9)	22 (88)	0.55
No	2 (7.1)	3(12)	0.55
Facial involvement, n (%)
Yes	8 (28.6)	6 (24)	0.71
No	20 (71.4)	19 (76)	0.71
Nasolabial involvement, n (%)
Yes	3 (10.7)	1 (4)	0.36
No	25 (89.3)	24 (96)	0.36
Eyebrow involvement, n (%)
Yes	6 (21.4)	5 (20)	0.89
No	22 (78.6)	20 (80%)	0.89
Ear involvement, n (%)
Yes	6 (21.4)	5 (20)	0.89
No	22 (78.6)	20 (80%)	0.89
Chin involvement, n (%)
Yes	2 (7.1)	2 (8)	0.91
No	26 (92.9)	23 (92)	0.91
Chest involvement, n (%)
Yes	6 (21.4)	4 (16)	0.61
No	22 (78.6)	21 (84)	0.61
Smoking status, n (%)
Yes	7 (25)	3 (12)	0.23
No	21 (75)	22 (88)	0.23
Alcohol use, n (%)
Yes	3 (10.7)	2 (8)	0.73
No	25 (89.3)	23 (92)	0.73
Additional systemic disease, n (%)
Yes	10 (35.7)	7 (28)	0.55
No	18 (64.3)	18 (72)	0.55
Additional skin disease, n (%)
Yes	1 (3.6)	5(20)	0.089
None	27 (96.4)	20 (80%)	0.089
Subjective stress, n (%)
Yes	17 (60.7)	14 (56)	0.73
No	11 (39.3)	11 (44)	0.73

	Patient group	Control group	p-value
Calcium (mg/dL), average (standard deviation) (n=8.7–10.4)	9.61 (0.76)	9.69 (0.61)	0.52
Phosphorus (mg/dL), average (standard deviation) (n=2.4–5.1)	3.47 (0.52)	3.75 (0.54)	0.013
Parathormone (ng/L), median (IQR) (n=18.4–80.1)	35.7 (28–55.3)	40.5 (32.5–54.5)	0.63

	Those with severe vit D deficiency	Those without severe vit D deficiency	p-value
Calcium (mg/dL), average (standard deviation)	9.61 (0.79)	9.8 (0.59)	0.75
Phosphorus (mg/dL), average (standard deviation	3.63 (0.57)	3.66 (0.54)	0.72
Parathormone (ng/L), median (IQR)	39.9 (30.8–53)	36.7 (28.5–56.8)	0.87

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[1] *Corresponding author: fykilinc@yahoo.com