Podocin |
Podocytes injury |
Urine |
RT-QPCR |
21 DN patients by biopsy |
9 |
- |
Increased |
[
4242 Hara M, Yamagata K, Tomino Y, Saito A, Hirayama Y, Ogasawara S, et al. Urinary podocalyxin is an early marker for podocyte injury in patients with diabetes: establishment of a highly sensitive ELISA to detect urinary podocalyxin. Diabetologia. 2012; 55(11):2913-9.
]
|
Synaptopodin |
Podocytes injury |
Urine |
RT-QPCR |
21 DN patients by biopsy |
9 |
- |
Increased |
[
4242 Hara M, Yamagata K, Tomino Y, Saito A, Hirayama Y, Ogasawara S, et al. Urinary podocalyxin is an early marker for podocyte injury in patients with diabetes: establishment of a highly sensitive ELISA to detect urinary podocalyxin. Diabetologia. 2012; 55(11):2913-9.
]
|
|
|
Urine |
ELISA |
71 (39 normo/17 micro/15 macro) |
69 |
- |
Increased
|
[
4343 Jim B, Ghanta M, Qipo A, Fan Y, Chuang PY, Cohen HW, et al. Dysregulated nephrin in diabetic nephropathy of type 2 diabetes: a cross sectional study. PLoS One. 2012; 7(5):e36041.
]
|
Nephrin |
Podocytes injury |
Urine |
RT-QPCR |
21 DN patients by biopsy |
9 |
- |
Increased |
[
4242 Hara M, Yamagata K, Tomino Y, Saito A, Hirayama Y, Ogasawara S, et al. Urinary podocalyxin is an early marker for podocyte injury in patients with diabetes: establishment of a highly sensitive ELISA to detect urinary podocalyxin. Diabetologia. 2012; 55(11):2913-9.
]
|
|
|
Urine |
ELISA |
66 (26 normo/11 micro/29 macro) |
10 |
- |
Increased
|
[
4444 Tomino Y, Suzuki S, Azushima C, Shou I, Iijima T, Yagame M, et al. Asian multicenter trials on urinary type IV collagen in patients with diabetic nephropathy. J Clin Lab Anal. 2001; 15(4):188-92.
]
|
Type IV collagen |
Basement membrane injury |
Urine |
ELISA |
698 DM (264 normo/169 micro/181 macro/84 renal failure) |
191 |
- |
Increased |
[
4545 Jensen T. Increased plasma concentration of von Willebrand factor in insulin dependent diabetics with incipient nephropathy. BMJ. 1989; 298(6665):27-8.
]
|
vWF |
Endothelial cells injury |
Plasma |
ELISA |
109 (66 normo/26 micro/17 macro) |
- |
31 nondiabetic |
Increased |
[
4747 Hirano T, Ookubo K, Kashiwazaki K, Tajima H, Yoshino G, Adachi M. Vascular endothelial markers, von Willebrand factor and thrombomodulin index, are specifically elevated in type 2 diabetic patients with nephropathy: comparison of primary renal disease. Clin Chim Acta. 2000; 299(1-2):65-75.
]
|
|
|
Plasma |
ELISA |
24 (12 normo/12 micro) |
12 |
- |
Increased |
[
4848 Fang YH, Zhang JP, Zhou SX, Zheng JF, Yu YW, Yan SG, et al. [Relationship between serum vWF and PAF in type 2 diabetic patients and diabetic nephropathy]. Di Yi Jun Yi Da Xue Xue Bao. 2005; 25(6):729-31.
]
|
|
|
Serum |
ELISA |
60 (30 DN/30 without DN) |
60 |
- |
Increased |
[
4949 Nong S, Ke L, Zhang X, Huang X, Man Y, Wang S, et al. Mechanism underlying up-regulation of ICAM-1 and VCAM-1 expressions induced by high glucose in endothelial cells. Chinese J Cardiovasc Med. 2010; 15(3):219-22.
]
|
VEGF |
Endothelial cells injury |
plasma |
ELISA |
387 T1DM (188 normo/199 DN) |
- |
- |
Increased |
[
5252 Kim NH, Kim KB, Kim DL, Kim SG, Choi KM, Baik SH, et al. Plasma and urinary vascular endothelial growth factor and diabetic nephropathy in Type 2 diabetes mellitus. Diabet Med. 2004; 21(6):545-51.
]
|
|
|
Urine |
ELISA |
107 (37 normo/37 micro/ 33 proteinuria) |
47 |
- |
Increased
|
[
5353 Tamaki K, Okuda S. Role of TGF-beta in the progression of renal fibrosis. Contrib Nephrol. 2003; 139:44-65.
]
|
TGF-b1 |
Mesangial expansion/fibrosis |
Serum/urine |
ELISA |
54 (20 normo/34 micro) |
30 |
- |
Increased |
[
5555 Wang JJ, Zhang SX, Lu K, Chen Y, Mott R, Sato S, et al. Decreased expression of pigment epithelium-derived factor is involved in the pathogenesis of diabetic nephropathy. Diabetes. 2005; 54(1):243-50.
]
|
PEDF |
Mesangial expansion/fibrosis |
Urine |
ELISA |
228 (59 normo/130 micro/ 39 macro) |
46 |
- |
Increased |
[
5757 Cohen-Bucay A, Viswanathan G. Urinary markers of glomerular injury in diabetic nephropathy. Int J Nephrol. 2012; 2012:146987.
]
|