Brain metastasis as initial presentation of papillary adenocarcinoma of the lung: case report

The authors describe the case of a 33-year-old patient with history of seizures alone without any previous symptom, being diagnosed with brain metastases from primary papillary adenocarcinoma of the lung. Emphasis is given to the diagnostic investigation for brain metastasis and prognostic evaluation of papillary adenocarcinoma of the lung, and a brief literature review on such diseases is performed.

Neoplastic metastasis; Papillary adenocarcinoma; Immunohistochemistry

Authorship

Irving Gabriel Araújo Bispo

MD, Resident of Medical Practice, Hospital Universitário – Universidade Federal de Sergipe (HU-UFS), Aracaju, SE, BrazilUniversidade Federal de SergipeBrazilAracaju, SE, BrazilMD, Resident of Medical Practice, Hospital Universitário – Universidade Federal de Sergipe (HU-UFS), Aracaju, SE, Brazil

Diego Teixeira Nascimento

MD, Resident of Radiology and Imaging Diagnosis, Hospital Universitário – Universidade Federal de Sergipe (HU-UFS), Aracaju, SE, BrazilUniversidade Federal de SergipeBrazilAracaju, SE, BrazilMD, Resident of Radiology and Imaging Diagnosis, Hospital Universitário – Universidade Federal de Sergipe (HU-UFS), Aracaju, SE, Brazil

Karina Oliveira Ferreira

MD, Clinical Oncologist, Hospital Universitário – Universidade Federal de Sergipe (HU-UFS), Aracaju, SE, BrazilUniversidade Federal de SergipeBrazilAracaju, SE, BrazilMD, Clinical Oncologist, Hospital Universitário – Universidade Federal de Sergipe (HU-UFS), Aracaju, SE, Brazil

Ricardo Fakhouri

Associate Professor of General Pathology and Pathological Anatomy, Universidade Federal de Sergipe (UFS), Aracaju, SE, BrazilUniversidade Federal de SergipeBrazilAracaju, SE, BrazilAssociate Professor of General Pathology and Pathological Anatomy, Universidade Federal de Sergipe (UFS), Aracaju, SE, Brazil

Atilano Salvador Godinho

MD, Radiologist, Residency Coordinator, Department of Radiology and Imaging Diagnosis, Hospital Universitário – Universidade Federal de Sergipe (HU-UFS), Aracaju, SE, BrazilUniversidade Federal de SergipeBrazilAracaju, SE, BrazilMD, Radiologist, Residency Coordinator, Department of Radiology and Imaging Diagnosis, Hospital Universitário – Universidade Federal de Sergipe (HU-UFS), Aracaju, SE, Brazil

Thiago de Oliveira Ferrão

Titular Member of Colégio Brasileiro de Radiologia e Diagnóstico por Imagem (CBR), Fellow PhD Degree and Residency Preceptor, Department of Radiology and Imaging Diagnosis, Hospital Universitário – Universidade Federal de Sergipe (HU-UFS), Aracaju, SE, BrazilUniversidade Federal de SergipeBrazilAracaju, SE, BrazilTitular Member of Colégio Brasileiro de Radiologia e Diagnóstico por Imagem (CBR), Fellow PhD Degree and Residency Preceptor, Department of Radiology and Imaging Diagnosis, Hospital Universitário – Universidade Federal de Sergipe (HU-UFS), Aracaju, SE, Brazil

Mailing Address: Dr. Irving Gabriel Araújo Bispo. Avenida Augusto Franco, 3553, Condomínio Recanto dos Pássaros, Bloco I, ap. 504, Bairro Ponto Novo. Aracaju, SE, Brazil, 49047-040. E-mail: irvingbispo@yahoo.com.br.

SCIMAGO INSTITUTIONS RANKINGS

Figures

Figures (2)

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Figure 1.
Cranial MRI. A: Axial, T1-weighted image – cortical-subcortical, expansile, nodular lesion in the left temporal lobe with a central isointense component and hypersignal halo. B: Axial, T2-weighted image – mild central hypersignal and peripheral hyposignal. C: Axial, contrast-enhanced T1-weighted image with fatsat – subtle peripheral gadolinium enhancement. D: Axial, T2-weighted image – marked and slightly heterogeneous hyposignal. E: Axial, FLAIR image – mild hypersignal in the central component and hyposignal halo, with perilesional edema. F: Axial, diffusion-weighted image. G: Axial, ADC mapping. H: Axial, T2-weighted gradient image – multiple lesions with peripheral hyposignal. I: Sagittal, contrast-enhanced T1-weighted image – multiple lesions with ring-shaped uptake.

Thumbnail

Figure 2.
Image showing immunohistochemistry test results with positive markers for TTF-1 (A) and napsin-A (B).

Figure 1. Cranial MRI. A: Axial, T1-weighted image – cortical-subcortical, expansile, nodular lesion in the left temporal lobe with a central isointense component and hypersignal halo. B: Axial, T2-weighted image – mild central hypersignal and peripheral hyposignal. C: Axial, contrast-enhanced T1-weighted image with fatsat – subtle peripheral gadolinium enhancement. D: Axial, T2-weighted image – marked and slightly heterogeneous hyposignal. E: Axial, FLAIR image – mild hypersignal in the central component and hyposignal halo, with perilesional edema. F: Axial, diffusion-weighted image. G: Axial, ADC mapping. H: Axial, T2-weighted gradient image – multiple lesions with peripheral hyposignal. I: Sagittal, contrast-enhanced T1-weighted image – multiple lesions with ring-shaped uptake.

Figure 2. Image showing immunohistochemistry test results with positive markers for TTF-1 (A) and napsin-A (B).

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E-mail: radiologiabrasileira@cbr.org.br

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