Subarachnoid meloxicam does not inhibit the mechanical hypernociception on carrageenan test in rats

Moura, Lanucha Fidelis da Luz; Vidor, Silvana Bellini; Trindade, Anelise Bonilla; Mörschbächer, Priscilla Domingues; Oleskovicz, Nilson; Contesini, Emerson Antonio

doi:10.1016/j.bjane.2013.10.020

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Scientific Articles • Rev. Bras. Anestesiol. 65 (2) • Mar-Apr 2015 • https://doi.org/10.1016/j.bjane.2013.10.020 copy

Subarachnoid meloxicam does not inhibit the mechanical hypernociception on carrageenan test in rats ^☆ ☆ Work conducted at Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, RS, Brazil.

Authorship SCIMAGO INSTITUTIONS RANKINGS

BACKGROUND AND OBJECTIVE:

Evaluate the antinociceptive effects of subarachnoid meloxicam on the mechanical hypernociception induced by carrageenan in rats.

METHODS:

Randomized controlled trial. Eighteen adult male Wistar rats underwent a cannula implantation into the subarachnoid space and were randomly divided into two groups: Group I received saline solution 5 µL, while Group II received meloxicam 30 mg. The mechanical hypernociception was induced by intraplantar injection of carrageenan and evaluated using a digital analgesy meter every 30 min during a 4-h period. The results were recorded as the Δ withdrawal threshold (in g), calculated by subtracting the measurement value after treatment from baseline.

RESULTS:

The Δ withdrawal threshold mean values were lower in the group of patients treated with meloxicam over all time points between 45 and 165 min, however, there was no statistical significance (p = 0.835) for this difference.

CONCLUSION:

Subarachnoid meloxicam at a dose of 30 µg animal^-1 did not suppress the mechanical hypernociception in a model of inflammatory pain induced by intraplantar administration of carrageenan in rats. The data suggest that other dosages should be investigated the drug effect is discarded.

NSAIDs; Carrageenan; Pain; Spinal cord

Time points	Estimated mean difference	Standard error	p
30–60 min	-4.13	3.38	0.914
30–90 min	-5.60	3.82	0.813
30–120 min	-7.59	2.96	0.234
30–150 min	-13.64	4.03	0.055
30–180 min	-15.30	4.24	0.036
30–210 min	-23.50	3.68	<0.001
30–240 min	-27.76	2.53	<0.001
60–90 min	-1.47	2.42	0.998
60–120 min	-3.46	2.58	0.872
60–150 min	-9.51	3.13	0.104
60–180 min	-11.16	3.67	0.104
60–210 min	-19.37	2.71	<0.001
60–240 min	-23.63	2.88	<0.001
90–120 min	-1.99	2.84	0.996
90–150 min	-8.04	2.67	0.111
90–180 min	-9.70	3.35	0.136
90–210 min	-17.90	2.71	<0.001
90–240 min	-22.16	2.99	<0.001
120–150 min	-6.06	2.41	0.254
120–180 min	-7.71	3.81	0.497
120–210 min	-15.92	2.22	<0.001
120–240 min	-20.18	2.80	<0.001
150–180 min	-1.65	3.37	1.000
150–210 min	-9.86	2.60	0.025
150–240 min	-14.12	3.02	0.004
180–210 min	-8.21	2.36	0.046
180–240 min	-12.47	3.03	0.013
210–240 min	-4.26	2.48	0.677

Sociedade Brasileira de Anestesiologia R. Professor Alfredo Gomes, 36, 22251-080 Botafogo RJ Brasil, Tel: +55 21 2537-8100, Fax: +55 21 2537-8188 - Campinas - SP - Brazil
E-mail: bjan@sbahq.org

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[1] * Corresponding author. E-mail: lanucha moura@terra.com.br (L.F.L. Moura)

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Subarachnoid meloxicam does not inhibit the mechanical hypernociception on carrageenan test in rats ☆ ☆ Work conducted at Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, RS, Brazil.

BACKGROUND AND OBJECTIVE:

METHODS:

RESULTS:

CONCLUSION:

Subarachnoid meloxicam does not inhibit the mechanical hypernociception on carrageenan test in rats ^☆ ☆ Work conducted at Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, RS, Brazil.