51-55 |
Iqbal et al.[2323 Iqbal J, Ghaffar A, Shahbaz A, Abid AR. Stroke after coronary artery bypass surgery with and without cardiopulmonary bypass. J Ayub Med Coll Abbottabad. 2014;26(2):123-8.], 2014 Pakistan |
100 (100) |
53.5 ± 10 (51.6 ± 10.3) |
NR |
Encephalopathy Hospital stay ICU stay MI Mortality Renal failure Stroke Ventilation time |
56-60 |
Bicer et al.[2424 Bicer M, Senturk T, Yanar M, Tutuncu A, Oral AY, Ulukaya E, et al. Effects of off-pump versus on-pump coronary artery bypass grafting: apoptosis, inflammation, and oxidative stress. Heart Surg Forum. 2014;17(5):E271-6. doi:10.1532/HSF98.2014326. https://doi.org/10.1532/HSF98.2014326...
], 2014 Turkey |
25 (25) |
56.9 ± 10.7 (57.7 ± 8.4) |
88 (88) |
Mortality MDA hs-CRP M30 M65 |
|
Gerola et al.[2525 Gerola LR, Buffolo E, Jasbik W, Botelho B, Bosco J, Brasil LA, et al. Off-pump versus on-pump myocardial revascularization in low-risk patients with one or two vessel disease: perioperative results in a multicenter randomized controlled trial. Ann Thorac Surg. 2004;77(2):569-73. doi:10.1016/S0003-4975(03)01353-5. https://doi.org/10.1016/S0003-4975(03)01...
], 2004 Brazil |
80 (80) |
58.9 ± 8.9 (59.1 ± 9.7) |
68 (64) |
Atrial fibrillation CK-MB Hospital stay ICU stay MI Mortality Stroke |
|
Kobayashi et al.[2626 Kobayashi J, Tashiro T, Ochi M, Yaku H, Watanabe G, Satoh T, et al. Early outcome of a randomized comparison of off-pump and on-pump multiple arterial coronary revascularisation. Circulation. 2005;112(9 Suppl):I338-43. doi:10.1161/CIRCULATIONAHA.104.524504. https://doi.org/10.1161/CIRCULATIONAHA.1...
] (JOCRI), 2005 Japan |
86 (81) |
59 ± 10 (60 ± 7) |
86 (87) |
Atrial fibrillation CK-MB Graft patency ICU stay MI Mortality Neuron specific enolase S-100 protein Stroke Ventilation time |
|
Penttila et al.[2727 Penttilä HJ, Lepojärvi MV, Kiviluoma KT, Kaukoranta PK, Hassinen IE, Peuhkurinen KJ. Myocardial preservation during coronary surgery with and without cardiopulmonary bypass. Ann Thorac Surg. 2001;71(2):565-71. doi:10.1016/s0003-4975(00)02002-6. https://doi.org/10.1016/s0003-4975(00)02...
], 2001 Finland |
11 (11) |
59.2 59.5 |
NR |
MI Myocardial markers Myocardial metabolism |
61-65 |
Al-Ruzzeh et al.[2828 Al-Ruzzeh S, George S, Bustami M, Wray J, Ilsley C, Athanasiou T, et al. Effect of off-pump coronary artery bypass surgery on clinical, angiographic, neurocognitive, and quality of life outcomes: randomised controlled trial. BMJ. 2006;332(7554):1365. doi:10.1136/bmj.38852.479907.7C. https://doi.org/10.1136/bmj.38852.479907...
], 2006 UK |
84 (84) |
63.1 ± 9.6 (63.1 ± 11) |
84 (83) |
Atrial fibrillation Blood transfusions Graft patency Health-related quality of life Hospital stay ICU stay Mortality Neurocognitive function Stroke Ventilation time |
|
Angelini et al.[2929 Angelini GD, Taylor FC, Reeves BC, Ascione R. Early and midterm outcome after off-pump and on-pump surgery in beating heart against cardioplegic arrest studies (BHACAS 1 and 2): a pooled analysis of two randomised controlled trials. Lancet 2002;359(9313):1194-9. doi:10.1016/S0140-6736(02)08216-8. https://doi.org/10.1016/S0140-6736(02)08...
], 2002 UK |
BHACAS 1 100 (100) BHACAS 2 101 (100) |
BHACAS 1 61.7 ± 8.6 (62.2 ± 9.6) BHACAS 2 61.2 ± 9.2 (63.8 ± 8.5) |
BHACAS 1 79 (82) BHACAS 2 85 (82) |
Atrial fibrillation MI Mortality Stroke |
|
Ascione et al.[3030 Ascione R, Caputo M, Calori G, Lloyd CT, Underwood MJ, Angelini GD. Predictors of atrial fibrillation after conventional and beating heart coronary surgery: a prospective, randomized study. Circulation. 2000;102(13):1530-5. doi:10.1161/01.cir.102.13.1530. https://doi.org/10.1161/01.cir.102.13.15...
], 2000 UK |
100 (100) |
63 (63) |
79 (82) |
Atrial fibrillation Hospital stay ICU stay MI Mortality Stroke Ventilation time |
|
Fattouch et al.[3131 Fattouch K, Guccione F, Dioguardi P, Sampognaro R, Corrado E, Caruso M, et al. Off-pump versus on-pump myocardial revascularization in patients with ST-segment elevation myocardial infarction: a randomized trial. J Thorac Cardiovasc Surg. 2009;137(3):650-6; discussion 656-7. doi:10.1016/j.jtcvs.2008.11.033. https://doi.org/10.1016/j.jtcvs.2008.11....
], 2009 Italy |
65 (63) |
61 ± 18 (63 ± 16) |
77 (61) |
cTnI Cardiac contractile function Hospital stay ICU stay Mortality Ventilation time |
|
Jongman et al.[3232 Jongman RM, Zijlstra JG, Kok WF, van Harten AE, Mariani MA, Moser J, et al. Off-pump CABG surgery reduces systemic inflammation compared with on-pump surgery but does not change systemic endothelial responses: a prospective randomized study. Shock. 2014;42(2):121-8. doi:10.1097/SHK.0000000000000190. https://doi.org/10.1097/SHK.000000000000...
], 2014 The Netherlands |
29 (30) |
63 (63) |
90 (90) |
Cardiac failure Inflammatory markers Major bleeding Pulmonary embolism Renal failure Stroke |
|
Khan et al.[3333 Khan NE, De Souza A, Mister R, Flather M, Clague J, Davies S, et al. A randomized comparison of off-pump and on-pump multivessel coronary- artery bypass surgery. N Engl J Med. 2004;350(1):21-8. doi:10.1056/NEJMoa031282. https://doi.org/10.1056/NEJMoa031282...
], 2004 UK |
50 (54) |
64.7 |
82 (93) |
Blood loss Extubation time Hospital stay ICU stay Infection Low cardiac output MI Mortality Repeat surgery |
|
Kok et al.[3434 Kok WF, van Harten AE, Koene BM, Mariani MA, Koerts J, Tucha O, et al. A pilot study of cerebral tissue oxygenation and postoperative cognitive dysfunction among patients undergoing coronary artery bypass grafting randomised to surgery with or without cardiopulmonary bypass. Anaesthesia. 2014;69(6):613-22. doi:10.1111/anae.12634. https://doi.org/10.1111/anae.12634...
], 2014 The Netherlands |
29 (30) |
62.6 ± 9.9 (63 ± 9) |
90 (90) |
Cerebral oxygenation Cognitive dysfunction Hospital stay ICU stay Stroke |
|
Légaré et al.[3535 Légaré JF, Buth KJ, King S, Wood J, Sullivan JA, Hancock Friesen C, et al. Coronary bypass surgery performed off pump does not result in lower in-hospital morbidity than coronary artery bypass grafting performed on pump. Circulation. 2004;109(7):887-92. doi:10.1161/01.CIR.0000115943.41814.7D. https://doi.org/10.1161/01.CIR.000011594...
], 2004 Canada |
150 (150) |
63.7 ± 10 (62.1 ± 10.1) |
79 (81) |
Atrial fibrillation Hospital stay ICU stay MI Mortality Stroke Transfusion requirement Ventilation time Wound infection |
|
Lingaas et al.[3636 Lingaas PS, Hol PK, Lundblad R, Rein KA, Tønnesen TI, Svennevig JL, et al. Clinical and angiographic outcome of coronary surgery with and without cardiopulmonary bypass: a prospective randomized trial. Heart Surg Forum. 2004;7(1):37-41.], 2004 Norway |
60 (60) |
65 ± 8.3 64 ± 7.8 |
72 (85) |
CPB time Ventilation time Reintubation Bleeding Blood transfusions Atrial fibrillation CK-MB Aspartate aminotransferase Stroke Mortality Mediastinitis Graft patency |
|
Lund et al.[3737 Lund C, Hol PK, Lundblad R, Fosse E, Sundet K, Tennøe B, et al. Comparison of cerebral embolization during off-pump and on-pump coronary artery bypass surgery. Ann Thorac Surg. 2003;76(3):765-70; discussion 770. doi:10.1016/s0003-4975(03)00679-9. https://doi.org/10.1016/s0003-4975(03)00...
], 2003 Norway |
22 (29) |
64 (62) |
73.9 (89.7) |
Cerebral blood flow Cerebral MRI Neuropsychologic tests Stroke |
|
Michaux et al.[3838 Michaux I, Filipovic M, Skarvan K, Bolliger D, Schumann R, Bernet F, et al. A randomized comparison of right ventricular function after on-pump versus off-pump coronary artery bypass graft surgery. J Thorac Cardiovasc Surg. 2011;141(2):361-7. Erratum in: J Thorac Cardiovasc Surg. 2011;142(3):726. doi:10.1016/j.jtcvs.2010.02.023. https://doi.org/10.1016/j.jtcvs.2010.02....
], 2011 Switzerland |
25 (25) |
65 ± 8 (61 ± 9) |
84 (84) |
Atrial fibrillation cTnI Hospital stay ICU stay MI Mortality Right ventricular function Ventilation time >12 hours |
|
Motallebzdah et al.[3939 Motallebzadeh R, Kanagasabay R, Bland JM, Kaski JC, Jahangiri M. S100 protein and its relation to cerebral microemboli in on-pump and off-pump coronary artery bypass surgery. Eur J Cardiothorac Surg. 2004;25(3):409-14. doi:10.1016/j.ejcts.2003.12.018. https://doi.org/10.1016/j.ejcts.2003.12....
], 2004 UK |
20 (15) |
63 (65) |
90 (93) |
Cerebral blood flow S100 protein Stroke |
|
Motallebzdah et al.[4040 Motallebzadeh R, Bland JM, Markus HS, Kaski JC, Jahangiri M. Neurocognitive function and cerebral emboli: randomized study of on-pump versus off-pump coronary artery bypass surgery. Ann Thorac Surg. 2007;83(2):475-82. doi:10.1016/j.athoracsur.2006.09.024. https://doi.org/10.1016/j.athoracsur.200...
], 2007 UK |
104 (108) |
65.1 ± 0.9 (63.9 ± 0.9) |
91 (87) |
Cerebral emboli Mortality Neurocognitive function Stroke |
|
Nathoe et al.[4141 Nathoe HM, van Dijk D, Jansen EW, Suyker WJ, Diephuis JC, van Boven WJ, et al. A comparison of on-pump and off-pump coronary bypass surgery in low-risk patients. N Engl J Med. 2003;348(5):394-402. doi:10.1056/NEJMoa021775. https://doi.org/10.1056/NEJMoa021775...
] (Octopus), 2003 USA |
139 (142) |
60.8 ± 8.8 61.7 ± 9.2 |
71 (66) |
Cost MI Mortality Quality of life Repeat revascularisation Stroke |
|
Puskas et al.[4242 Puskas JD, Williams WH, Duke PG, Staples JR, Glas KE, Marshall JJ, et al. Off-pump coronary artery bypass grafting provides complete revascularization with reduced myocardial injury, transfusion requirements, and length of stay: a prospective randomized comparison of two hundred unselected patients undergoing off-pump versus conventional coronary artery bypass grafting. J Thorac Cardiovasc Surg. 2003;125(4):797-808. doi:10.1067/mtc.2003.324. https://doi.org/10.1067/mtc.2003.324...
] (SMART), 2003 USA |
99 (98) |
62.5 ± 9.5 (62.2 ± 11.1) |
77 (78) |
Atrial fibrillation Coagulopathy and transfusion Hospital stay ICU stay MI Mortality Stroke |
|
Rastan et al.[4343 Rastan AJ, Bittner HB, Gummert JF, Walther T, Schewick CV, Girdauskas E, et al. On-pump beating heart versus off-pump coronary artery bypass surgery-evidence of pump-induced myocardial injury. Eur J Cardiothorac Surg. 2005;27(6):1057-64. doi:10.1016/j.ejcts.2005.03.007. https://doi.org/10.1016/j.ejcts.2005.03....
], 2005 Germany |
20 (20) |
65.3 ± 3.9 (63 ± 6) |
80 (80) |
CK-MB C-reactive protein cTnI Intraoperative myocardial ischaemia MI Mortality NT-proBNP Oxidative stress Stroke |
|
Sahlman et al.[4444 Sahlman A, Ahonen J, Nemlander A, Salmenperä M, Eriksson H, Rämö J, et al. Myocardial metabolism on off-pump surgery; a randomized study of 50 cases. Scand Cardiovasc J. 2003;37(4):211-5. doi:10.1080/14017430310001726. https://doi.org/10.1080/1401743031000172...
], 2003 Finland |
26 (24) |
61.5 ± 8.1 (64 ± 9) |
77 (88) |
Extubation time Bleeding CK-MB ICU stay Hospital stay Weight gain Complement C3 C4 Protein carbonyls Wound infection Low cardiac output syndrome Cerebral infarction Oxidative stress markers |
|
Shroyer et al.[4545 Shroyer AL, Grover FL, Hattler B, Collins JF, McDonald GO, Kozora E, et al. On-pump versus off-pump coronary-artery bypass surgery. N Engl J Med. 2009;361(19):1827-37. doi:10.1056/NEJMoa0902905. https://doi.org/10.1056/NEJMoa0902905...
] (ROOBY), 2009 USA |
1099 (1104) |
62.5 ± 8.5 (63 ± 8.5) |
99 (99) |
Cardiac arrest Coma Hospital stay ICU stay Mediastinitis Mortality New mechanical support Renal failure Reoperation Stroke Tracheostomy Ventilation time |
|
Straka et al. [4646 Straka Z, Widimsky P, Jirasek K, Stros P, Votava J, Vanek T, et al. Off-pump versus on-pump coronary surgery: final results from a prospective randomized study PRAGUE-4. Ann Thorac Surg. 2004;77(3):789-93. doi:10.1016/j.athoracsur.2003.08.039. https://doi.org/10.1016/j.athoracsur.200...
] (PRAGUE-4), 2004 Czech Republic |
184 (204) |
62 (63) |
86 (77) |
Atrial fibrillation Hospital stay ICU stay MI Mortality Renal failure Stroke Ventilation time |
|
Vedin et al.[4747 Vedin J, Nyman H, Ericsson A, Hylander S, Vaage J. Cognitive function after on or off pump coronary artery bypass grafting. Eur J Cardiothorac Surg. 2006;30(2):305-10. doi:10.1016/j.ejcts.2006.03.037. https://doi.org/10.1016/j.ejcts.2006.03....
], 2006 [4747 Vedin J, Nyman H, Ericsson A, Hylander S, Vaage J. Cognitive function after on or off pump coronary artery bypass grafting. Eur J Cardiothorac Surg. 2006;30(2):305-10. doi:10.1016/j.ejcts.2006.03.037. https://doi.org/10.1016/j.ejcts.2006.03....
] Sweden |
37 (33) |
65 (65) |
84 (78) |
Anxiety Cognitive function Depression MI Stroke |
66-70 |
Carrier et al.[4848 Carrier M, Perault LP, Jeanmart H, Martineau R, Cartier R, Page P. Randomized trial comparing off-pump to on-pump coronary artery bypass grafting in high risk patients. Heart Surg Forum. 2003;6(6):E89-92.], 2003 Canada |
37 (28) |
70 ± 6 (70 ± 8) |
84 (68) |
Mortality MI Stroke Renal insufficiency Respiratory failure/infection Bleeding Blood transfusions ICU stay Hospital stay |
|
Lamy et al [4949 Lamy A, Devereaux PJ, Prabhakaran D, Taggart DP, Hu S, Paolasso E, et al. Off-pump or on-pump coronary-artery bypass grafting at 30 days. N Engl J Med. 2012;366(16):1489-97. doi:10.1056/NEJMoa1200388. https://doi.org/10.1056/NEJMoa1200388...
] (CORONARY), 2012 Canada |
2377 (2375) |
67.5 ± 6.9 (67.6 ± 6.7) |
82 (80) |
Atrial fibrillation MI Mortality New renal failure Stroke |
|
Lee et al [5050 Lee JD, Lee SJ, Tsushima WT, Yamauchi H, Lau WT, Popper J, et al. Benefits of off-pump bypass on neurologic and clinical morbidity: a prospective randomized trial. Ann Thorac Surg. 2003;76(1):18-25; discussion 25-6. doi:10.1016/s0003-4975(03)00342-4. https://doi.org/10.1016/s0003-4975(03)00...
], 2003Hawaii |
30 (30) |
66 ± 11.2 (65.5 ± 9.6) |
73 (80) |
Cerebral microemboli Cerebral perfusion Cost Hospital stay Mortality Neurological function Stroke |
|
Muneretto et al.[5151 Muneretto C, Bisleri G, Negri A, Manfredi J, Metra M, Nodari S, et al. Off-pump coronary artery bypass surgery technique for total arterial myocardial revascularization: a prospective randomized study. Ann Thorac Surg. 2003;76(3):778-82; discussion 783. doi:10.1016/s0003-4975(03)00564-2. https://doi.org/10.1016/s0003-4975(03)00...
], 2003 Italy |
88 (88) |
66 ± 9 (67 ± 8) |
59 (63) |
Abdominal infarction Atrial fibrillation Hospital stay ICU stay MI Mortality Stroke Ventilation time |
|
Nesher et al.[5252 Nesher N, Frolkis I, Vardi M, Sheinberg N, Bakir I, Caselman F, et al. Higher levels of serum cytokines and myocardial tissue markers during on-pump versus off-pump coronary artery bypass surgery. J Card Surg. 2006;21(4):395-402. doi:10.1111/j.1540-8191.2006.00272.x. https://doi.org/10.1111/j.1540-8191.2006...
], 2006 Israel |
60 (60) |
68 ± 5 (67 ± 1) |
77 (73) |
CK-MB cTnI Cytokines Hospital stay Stroke Ventilation time |
|
Niranjan et al.[5353 Niranjan G, Asimakopoulos G, Karagounis A, Cockerill G, Thompson M, Chandrasekaran V. Effects of cell saver autologous blood transfusion on blood loss and homologous blood transfusion requirements in patients undergoing cardiac surgery on- versus off-cardiopulmonary bypass: a randomised trial. Eur J Cardiothorac Surg. 2006;30(2):271-7. doi:10.1016/j.ejcts.2006.04.042. https://doi.org/10.1016/j.ejcts.2006.04....
], 2006 UK |
40 (40) |
|
|
Atrial fibrillation Blood transfusion requirements Clotting tests Hospital stay ICU stay Mortality Postoperative blood loss Stroke Ventilation time |
71-75 |
Hlavicka et al.[5454 Hlavicka J, Straka Z, Jelinek S, et al. PPRAGUE-6 trial: off-pump versus on-pump coronary artery bypass graft surgery in patients with EuroSCORE 6. Prague: Third Faculty of Medicine, Charles University Prague; 2013 [cited 2019 Jul 21]. Available from: http://clinicaltrialresults.org/Slides/ACC%202013/Hlavicka_PRAGUE-6_ACC%202013.pdf http://clinicaltrialresults.org/Slides/A...
] (PRAGUE-6), 2016 Czech Republic |
108 (98) |
73.6 ± 7.4 74.7 ± 6.5 |
57.4 (59.2) |
MI Mortality Renal failure Stroke |
|
Houlind et al.[5555 Houlind K, Kjeldsen BJ, Madsen SN, Rasmussen BS, Holme SJ, Nielsen PH, et al. On-pump versus off-pump coronary artery bypass surgery in elderly patients: results from the Danish on-pump versus off-pump randomization study. Circulation. 2012;125(20):2431-9. doi:10.1161/CIRCULATIONAHA.111.052571. https://doi.org/10.1161/CIRCULATIONAHA.1...
] (DOORS), 2012 Denmark |
450 (450) |
75 (75) |
78 (76) |
Hospital stay ICU stay MI Mortality Quality of life Stroke |
|
Lemma et al.[5656 Lemma MG, Coscioni E, Tritto FP, Centofanti P, Fondacone C, Salica A, et al. On-pump versus off-pump coronary artery bypass surgery in high-risk patients: operative results of a prospective randomized trial (on-off study). J Thorac Cardiovasc Surg. 2012;143(3):625-31. doi:10.1016/j.jtcvs.2011.11.011. https://doi.org/10.1016/j.jtcvs.2011.11....
] (ON-OFF), 2012 Italy |
203 (208) |
73 (74) |
69 (70) |
MI Mortality Renal failure Stroke Reoperation for bleeding ARDS |
76-80 |
Diegeler et al. [1010 Diegeler A, Börgermann J, Kappert U, Breuer M, Böning A, Ursulescu A, et al. Off-pump versus on-pump coronary-artery bypass grafting in elderly patients. N Engl J Med. 2013;368(13):1189-98. doi:10.1056/NEJMoa1211666. https://doi.org/10.1056/NEJMoa1211666...
] (GOPCABE), 2013 Germany |
1207 (1187) |
78.4 ± 2.9 (78.6 ± 3.0) |
68 (69) |
Hospital stay ICU stay MI Mortality New renal-replacement therapy Repeat revascularisation Stroke Ventilation time |
|
Møller et al. [5757 Møller CH, Perko MJ, Lund JT, Andersen LW, Kelbaek H, Madsen JK, et al. No major differences in 30-day outcomes in high-risk patients randomized to off-pump versus on-pump coronary bypass surgery: the best bypass surgery trial. Circulation. 2010;121(4):498-504. doi:10.1161/CIRCULATIONAHA.109.880443. https://doi.org/10.1161/CIRCULATIONAHA.1...
] (BBS), 2010 Denmark |
163 (176) |
75.6 ± 4.9 (76.1 ± 5.2) |
64 (65) |
Cardiac arrest with successful resuscitation Coronary reintervention Low cardiac output syndrome MI Mortality Stroke |
|
Rogers et al.[5858 Rogers CA, Pike K, Campbell H, Reeves BC, Angelini GD, Gray A, et al. Coronary artery bypass grafting in high-RISk patients randomised to off- or on-pump surgery: a randomised controlled trial (the CRISP trial). Health Technol Assess. 2014;18(44):v-xx,1-157. doi:10.3310/hta18440. https://doi.org/10.3310/hta18440...
] (CRISP), 2014 UK |
53 (53) |
75.7 ± 7.7 (76.4 ± 5.8) |
76 (78) |
MI Mortality Prolonged initial ventilation Renal failure Sternal wound dehiscence Stroke |