Are there gender differences in left ventricular remodeling after
                    myocardial infarction in rats?

Antonio, Ednei Luiz; Serra, Andrey Jorge; Santos, Alexandra Alberta dos; Vieira, Stella Sousa; Silva, Jairo Montemor Augusto; Yoshizaki, Amanda; Sofia, Renato Rodrigues; Tucci, Paulo José Ferreira

doi:10.5935/1678-741.20140093

Acessibilidade / Reportar erro

Brasil

Brazilian Journal of Cardiovascular Surgery

Español English

Brasil

Español English

sumário « anterior atual seguinte »

Sumário

ORIGINAL ARTICLES • Rev Bras Cir Cardiovasc 30 (1) • Jan-Mar 2015 • https://doi.org/10.5935/1678-741.20140093 copy

Are there gender differences in left ventricular remodeling after myocardial infarction in rats?

Há diferenças entre os gêneros no remodelamento ventricular esquerdo após infarto do miocárdio em ratos?

Authorship SCIMAGO INSTITUTIONS RANKINGS

Objective:

An unclear issue is whether gender may influence at cardiac remodeling after myocardial infarction (MI). We evaluated left ventricle remodeling in female and male rats post-MI.

Methods:

Rats were submitted to anterior descending coronary occlusion. Echocardiographic evaluations were performed on the first and sixth week post-occlusion to determine myocardial infarction size and left ventricle systolic function (FAC, fractional area change). Pulsed Doppler was applied to analyze left ventricle diastolic function using the following parameters: E wave, A wave, E/A ratio. Two-way ANOVA was applied for comparisons, complemented by the Bonferroni test. A P≤=0.05 was considered significant.

Results:

There were no significant differences between genders for morphometric parameters on first (MI [Female (FE): 44.0±5.0 vs. Male (MA): 42.0±3.0%]; diastolic [FE: 0.04±0.003 vs. MA: 0.037±0.005, mm/g] and systolic [FE: 0.03±0.0004 vs. MA: 0.028±0.005, mm/g] diameters of left ventricle) and sixth (MI [FE: 44.0±5.0 vs. MA: 42.0±3.0, %]; diastolic [FE: 0.043±0.01 vs. MA: 0.034±0.005, mm/g] and systolic [FE: 0.035±0.01 vs. MA: 0.027±0.005, mm/g] of LV) week. Similar findings were reported for left ventricle functional parameters on first (FAC [FE: 34.0±6.0 vs. MA: 32.0±4.0, %]; wave E [FE: 70.0±18.0 vs. MA: 73.0±14.0, cm/s]; wave A [FE: 20.0±12.0 vs. MA: 28.0±13.0, cm/s]; E/A [FE: 4.9±3.4 vs. MA: 3.3±1.8]) and sixth (FAC [FE: 29.0±7.0 vs. MA: 31.0±7.0, %]; wave E [FE: 85.0±18.0 vs. MA: 87.0±20.0, cm/s]; wave A [FE: 20.0±11.0 vs. MA: 28.0±17.0, cm/s]; E/A [FE: 6.2±4.0 vs. MA: 4.6±3.4]) week.

Conclusion:

Gender does not influence left ventricle remodeling post-MI in rats.

Gender and Health; Myocardial Infarction; Ventricular Remodeling

Abbreviations, acronyms & symbols
FE	Female
LV	Left ventricle
MA	Male
MI	Myocardial infarction

	Female				Male
	Week 1	Week 1	Week 6	Week 6	Week 1	Week 1	Week 6	Week 6
	Sham	MI	Sham	MI	Sham	MI	Sham	MI
MI size(%)	----	44±5	----	42±9	----	42±3	----	42±7
SLA (mm)	4±0.5	4.9±1¹	4±0.2	6±1^* * P<0.05 vs. Sham on first and sixth week. ^# # P<0.05 vs. MI on first week	3±0.5	5±1^* * P<0.05 vs. Sham on first and sixth week.	3±0.4	6±1^* * P<0.05 vs. Sham on first and sixth week. ^# # P<0.05 vs. MI on first week
SLA/BW(mm/g)	0.02± 0.001	0.02±0.0005^* * P<0.05 vs. Sham on first and sixth week.	0.02±0.002	0.03±0.003^* * P<0.05 vs. Sham on first and sixth week.	0.01±0.002	0.02±0.0005^* * P<0.05 vs. Sham on first and sixth week.	0.01±0.0003	0.02±0.002^* * P<0.05 vs. Sham on first and sixth week.
LVDD(mm)	5±0.5	8±0.5^* * P<0.05 vs. Sham on first and sixth week.	5±1	9±1^* * P<0.05 vs. Sham on first and sixth week. ^# # P<0.05 vs. MI on first week	4±1	9±1^* * P<0.05 vs. Sham on first and sixth week.	5±1	10±0.01^* * P<0.05 vs. Sham on first and sixth week. ^# # P<0.05 vs. MI on first week
LVDD/BW(mm/g) 0.03± 0.002		0.04±0.003^* * P<0.05 vs. Sham on first and sixth week.	0.03±0.001	0.04±0.01^* * P<0.05 vs. Sham on first and sixth week.	0.03±0.001	0.04±0.005^* * P<0.05 vs. Sham on first and sixth week.	0.03±0.002	0.03±0.005^* * P<0.05 vs. Sham on first and sixth week.
LVSD(mm)	2±0.3	6±1^* * P<0.05 vs. Sham on first and sixth week.	3±1	7±1^* * P<0.05 vs. Sham on first and sixth week. ^# # P<0.05 vs. MI on first week	2±1	7±0.3^* * P<0.05 vs. Sham on first and sixth week.	3±1	8±0.3^* * P<0.05 vs. Sham on first and sixth week. ^# # P<0.05 vs. MI on first week
LVSD/BW(mm/g) 0.02± 0.002		0.03±0.0004^* * P<0.05 vs. Sham on first and sixth week.	0.02±0.0001	0.03±0.01^* * P<0.05 vs. Sham on first and sixth week.	0.02±0.0001	0.03±0.005^* * P<0.05 vs. Sham on first and sixth week.	0.02±0.0002	0.03±0.005^* * P<0.05 vs. Sham on first and sixth week.

	Female				Male
	Week 1	Week 1	Week 6	Week 6	Week 1	Week 1	Week 6	Week 6
	Sham	MI	Sham	MI	Sham	MI	Sham	MI
FAC (%)	63±4	34±6^* * P<0.05 vs. Sham on first and sixth week	67±3	29±7^* * P<0.05 vs. Sham on first and sixth week	66±7	32±4^* * P<0.05 vs. Sham on first and sixth week	63±4	31±7^* * P<0.05 vs. Sham on first and sixth week
E (cm/s)	69±2	70±2	73±6	85±2^* * P<0.05 vs. Sham on first and sixth week	59±2	73±1	67±4	87±2^* * P<0.05 vs. Sham on first and sixth week
A (cm/s)	24±1	20±1	29±5	20±1	30±5	28±1	30±6	28±2
E/A ratio	3±1	5±3	3±1	6±4^* * P<0.05 vs. Sham on first and sixth week	1±0.5	3±2	2±0.2	5±3^* * P<0.05 vs. Sham on first and sixth week

Authors’ roles & responsibilities
ELA	Data collection and analysis, experimental design and manuscript writing
AJS	Experimental design, statistical analysis and manuscript writing
AAS	Collection and analysis of data
SSV	Collection and analysis of data
JMAS	Collection and analysis of data
AY	Collection and analysis of data
RRS	Study design and manuscript writing
PJFT	Experimental design, getting funding for research, critical review of the manuscript

Sociedade Brasileira de Cirurgia Cardiovascular Rua Afonso Celso, 1178 Vila Mariana, CEP: 04119-061 - São Paulo/SP Brazil, Tel +55 (11) 3849-0341, Tel +55 (11) 5096-0079 - São Paulo - SP - Brazil
E-mail: bjcvs@sbccv.org.br

Acompanhe os números deste periódico no seu leitor de RSS

[1] Correspondence address: Andrey Jorge Serra, Postgraduate Program in Biophotonics Applied Health Sciences, Universidade Nove de Julho (UNINOVE), Rua Vergueiro, 235 , São Paulo, SP, Brazil Zip code: 01504-001. E-mail: andreyserra@gmail.com