Há diferenças entre os gêneros no remodelamento ventricular
                        esquerdo após infarto do miocárdio em ratos?

Antonio, Ednei Luiz; Serra, Andrey Jorge; Santos, Alexandra Alberta dos; Vieira, Stella Sousa; Silva, Jairo Montemor Augusto; Yoshizaki, Amanda; Sofia, Renato Rodrigues; Tucci, Paulo José Ferreira

doi:10.5935/1678-741.20140093

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Brasil

Brazilian Journal of Cardiovascular Surgery

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Brasil

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Sumário

ORIGINAL ARTICLES • Rev Bras Cir Cardiovasc 30 (1) • Jan-Mar 2015 • https://doi.org/10.5935/1678-741.20140093 copiar

Há diferenças entre os gêneros no remodelamento ventricular esquerdo após infarto do miocárdio em ratos?

Autoria SCIMAGO INSTITUTIONS RANKINGS

Objetivo:

A influência do gênero no remodelamento cardíaco após o infarto do miocárdio é uma questão em intenso debate. Nós avaliamos o remodelamento ventricular esquerdo em ratos infartados de ambos os gêneros.

Métodos:

O infarto do miocárdio foi induzido por oclusão da artéria coronária descendente anterior (fêmeas [FM]; machos [MC]). A ecocardiografia foi realizada na primeira e sexta semana pós-oclusão para determinar o tamanho do infarto do miocárdio e a função sistólica do ventricular esquerdo (mudança na área fracional [FAC]). A função diastólica derivou dos seguintes parâmetros: onda E; onda A; razão E/A. ANOVA duas vias com pós-teste de Bonferroni foi aplicado nas comparações (P≤=0,05).

Resultados:

Todas variáveis morfométricas foram similares (P>0,05) entre os gêneros com uma (infarto do miocárdio [FM: 44,0±5,0 vs. MC: 42,0±3,0, %]; diâmetro diastólico [FM: 0,04±0,003 vs. MC: 0,037±0,005, mm/g] e sistólico [FM: 0,03±0,0004 vs. MC: 0,028±0,005, mm/g] do VE) e seis (IM [FM: 44,0±5,0 vs. MC: 42,0±3,0, %]; diâmetro diastólico [FM: 0,043±0,01 vs. MC: 0,034±0,005, mm/g] e sistólico [FM: 0,035±0,01 vs. MC: 0,027±0,005, mm/g] do ventricular esquerdo) semanas. Achado similar ocorreu para os dados funcionais com uma (FAC [FM: 34,0±6,0 vs. MC: 32,0±4,0, %]; onda E [FM: 70,0±18,0 vs. MC: 73,0±14,0, cm/s]; onda A [FM: 20,0±12,0 vs. MC: 28,0±13,0, cm/s]; E/A [FM: 4,9±3,4 vs. MC: 3,3±1,8]) e seis (FAC [FM: 29,0±7,0 vs. MC: 31,0±7,0, %]; onda E [FM: 85,0±18,0 vs. MC: 87,0±20,0, cm/s]; onda A [FM: 20,0±11,0 vs. MC: 28,0±17,0 cm/s]; E/A [FM: 6,2±4,0 vs. MC: 4,6±3,4]) semanas.

Conclusão:

O gênero não é determinante para o remodelamento ventricular esquerdo pós-infarto do miocárdio em ratos.

Gênero e Saúde; Infarto do Miocárdio; Remodelação Ventricular

Abbreviations, acronyms & symbols
FE	Female
LV	Left ventricle
MA	Male
MI	Myocardial infarction

	Female				Male
	Week 1	Week 1	Week 6	Week 6	Week 1	Week 1	Week 6	Week 6
	Sham	MI	Sham	MI	Sham	MI	Sham	MI
MI size(%)	----	44±5	----	42±9	----	42±3	----	42±7
SLA (mm)	4±0.5	4.9±1¹	4±0.2	6±1^* * P<0.05 vs. Sham on first and sixth week. ^# # P<0.05 vs. MI on first week	3±0.5	5±1^* * P<0.05 vs. Sham on first and sixth week.	3±0.4	6±1^* * P<0.05 vs. Sham on first and sixth week. ^# # P<0.05 vs. MI on first week
SLA/BW(mm/g)	0.02± 0.001	0.02±0.0005^* * P<0.05 vs. Sham on first and sixth week.	0.02±0.002	0.03±0.003^* * P<0.05 vs. Sham on first and sixth week.	0.01±0.002	0.02±0.0005^* * P<0.05 vs. Sham on first and sixth week.	0.01±0.0003	0.02±0.002^* * P<0.05 vs. Sham on first and sixth week.
LVDD(mm)	5±0.5	8±0.5^* * P<0.05 vs. Sham on first and sixth week.	5±1	9±1^* * P<0.05 vs. Sham on first and sixth week. ^# # P<0.05 vs. MI on first week	4±1	9±1^* * P<0.05 vs. Sham on first and sixth week.	5±1	10±0.01^* * P<0.05 vs. Sham on first and sixth week. ^# # P<0.05 vs. MI on first week
LVDD/BW(mm/g) 0.03± 0.002		0.04±0.003^* * P<0.05 vs. Sham on first and sixth week.	0.03±0.001	0.04±0.01^* * P<0.05 vs. Sham on first and sixth week.	0.03±0.001	0.04±0.005^* * P<0.05 vs. Sham on first and sixth week.	0.03±0.002	0.03±0.005^* * P<0.05 vs. Sham on first and sixth week.
LVSD(mm)	2±0.3	6±1^* * P<0.05 vs. Sham on first and sixth week.	3±1	7±1^* * P<0.05 vs. Sham on first and sixth week. ^# # P<0.05 vs. MI on first week	2±1	7±0.3^* * P<0.05 vs. Sham on first and sixth week.	3±1	8±0.3^* * P<0.05 vs. Sham on first and sixth week. ^# # P<0.05 vs. MI on first week
LVSD/BW(mm/g) 0.02± 0.002		0.03±0.0004^* * P<0.05 vs. Sham on first and sixth week.	0.02±0.0001	0.03±0.01^* * P<0.05 vs. Sham on first and sixth week.	0.02±0.0001	0.03±0.005^* * P<0.05 vs. Sham on first and sixth week.	0.02±0.0002	0.03±0.005^* * P<0.05 vs. Sham on first and sixth week.

	Female				Male
	Week 1	Week 1	Week 6	Week 6	Week 1	Week 1	Week 6	Week 6
	Sham	MI	Sham	MI	Sham	MI	Sham	MI
FAC (%)	63±4	34±6^* * P<0.05 vs. Sham on first and sixth week	67±3	29±7^* * P<0.05 vs. Sham on first and sixth week	66±7	32±4^* * P<0.05 vs. Sham on first and sixth week	63±4	31±7^* * P<0.05 vs. Sham on first and sixth week
E (cm/s)	69±2	70±2	73±6	85±2^* * P<0.05 vs. Sham on first and sixth week	59±2	73±1	67±4	87±2^* * P<0.05 vs. Sham on first and sixth week
A (cm/s)	24±1	20±1	29±5	20±1	30±5	28±1	30±6	28±2
E/A ratio	3±1	5±3	3±1	6±4^* * P<0.05 vs. Sham on first and sixth week	1±0.5	3±2	2±0.2	5±3^* * P<0.05 vs. Sham on first and sixth week

Authors’ roles & responsibilities
ELA	Data collection and analysis, experimental design and manuscript writing
AJS	Experimental design, statistical analysis and manuscript writing
AAS	Collection and analysis of data
SSV	Collection and analysis of data
JMAS	Collection and analysis of data
AY	Collection and analysis of data
RRS	Study design and manuscript writing
PJFT	Experimental design, getting funding for research, critical review of the manuscript

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[1] Correspondence address: Andrey Jorge Serra, Postgraduate Program in Biophotonics Applied Health Sciences, Universidade Nove de Julho (UNINOVE), Rua Vergueiro, 235 , São Paulo, SP, Brazil Zip code: 01504-001. E-mail: andreyserra@gmail.com