Narayan et al.[2020 Narayan P, Kshirsagar SN, Mandal CK, Ghorai PA, Rao YM, Das D, et al. Preoperative glycosylated hemoglobin: a risk factor for patients undergoing coronary artery bypass. Ann Thorac Surg. 2017;104(2):606-12. doi:10.1016/j.athoracsur.2016.12.020. https://doi.org/10.1016/j.athoracsur.201...
], 2017 |
Retrospective |
Single centre (India) |
4,678 patients |
• |
30-day mortality was significantly higher in patients with HbA1c ≥6.5% when compared to those with HbA1c <6.5% (4.22% vs. 3.07%, P=0.0035), but in the multivariable analysis there was no significant difference in mortality (OR 1.36, 95%, CI 0.95-1.953, P=0.08) |
van den Boom et al.[2121 van den Boom W, Schroeder RA, Manning MW, Setji TL, Fiestan GO, Dunson DB. Effect of A1C and glucose on postoperative mortality in noncardiac and cardiac surgeries. Diabetes Care. 2018;41(4):782-8. doi:10.2337/dc17-2232. https://doi.org/10.2337/dc17-2232...
], 2018 |
Retrospective |
Single centre (USA) |
6,393 patients |
• |
HbA1c was found to not be a significant predictor of post-operative mortality in cardiac surgery (P=0.88) |
Tsuruta et al.[2222 Tsuruta R, Miyauchi K, Yamamoto T, Dohi S, Tambara K, Dohi T, et al. Effect of preoperative hemoglobin A1c levels on long-term outcomes for diabetic patients after off-pump coronary artery bypass grafting. J Cardiol. 2011;57(2):181-6. doi:10.1016/j.jjcc.2010.11.003. https://doi.org/10.1016/j.jjcc.2010.11.0...
], 2011 |
Prospective |
Single centre (Japan) |
306 patients |
• |
No significant difference in all-cause mortality or cardiac mortality between patients with HbA1c <6.5%, 6.5-7.5% and ≥7.5% (HR 0.80, 95% CI 0.49-1.23, P=0.26 and P=0.17, respectively) |
• |
Multivariate analysis showed that HbA1c did not predict mortality |
Ramadan et al.[2323 Ramadan M, Abdelgawad A, Elshemy A, Sarawy E, Emad A, Mazen M, et al. Impact of elevated glycosylated hemoglobin on hospital outcome and 1 year survival of primary isolated coronary artery bypass grafting patients. Egypt Heart J. 2018;70(2):113-8. doi:10.1016/j.ehj.2017.09.002. https://doi.org/10.1016/j.ehj.2017.09.00...
], 2018 |
Prospective |
Single centre (Egypt) |
80 patients |
• |
There was no statistically significant difference for in-hospital mortality between patients with HbA1c ≤7.0% and HbA1c >7.0% (2.5% vs. 7.5%, P=0.608) |
• |
There was no statistically significant difference for one-year mortality between patients with HbA1c ≤7.0% and HbA1c >7.0% (5.13% vs. 8.11%, P=0.600) |
Subramaniam et al.[2424 Subramaniam B, Lerner A, Novack V, Khabbaz K, Paryente-Wiesmann M, Hess P, et al. Increased glycemic variability in patients with elevated preoperative HbA1C predicts adverse outcomes following coronary artery bypass grafting surgery. Anesth Analg. 2014;118(2):277-87. doi:10.1213/ANE.0000000000000100.n.24 https://doi.org/10.1213/ANE.000000000000...
], 2014 |
Prospective |
Single centre (Israel) |
1,461 patients |
• |
No statistically significant difference in the incidence of death between patients with HbA1c <6.5% and with HbA1c ≥6.5% (3% vs. 2.6%, P=0.90) |
Biskupski et al.[2828 Biskupski A, Waligórski S, Kowalik B, Żych A, Sielicki P, Mirecki O, et al. Glycated hemoglobin HbA1c - a new risk marker for the outcome of cardiac surgery? Kardiochir Torakochirurgia Pol. 2014;11(1):7-11. doi:10.5114/kitp.2014.41922. n.28 https://doi.org/10.5114/kitp.2014.41922...
], 2014 |
Retrospective |
Single centre (Poland) |
350 patients |
• |
There was no significant difference in the incidence of death between patients with HbA1c <7.0% compared to HbA1c 7.0-8.0% (1.02% vs. 2.27%, P=0.78) |
• |
There was no significant difference in the incidence of death between patients with HbA1c <7.0% and with HbA1c >8.0% (1.02% vs. 4.74%, P=0.20) |
Finger et al.[3030 Finger B, Brase J, He J, Gibson WJ, Wirtz K, Flynn BC. Elevated hemoglobin A1c is associated with lower socioeconomic position and increased postoperative infections and longer hospital stay after cardiac surgical procedures. Ann Thorac Surg. 2017;103(1):145-51. doi:10.1016/j.athoracsur.2016.05.092. https://doi.org/10.1016/j.athoracsur.201...
], 2017 |
Retrospective |
Single centre (USA) |
531 patients+D21:D24D19:D24 |
• |
There was no statistically significant difference in 30-day mortality between patients with HbA1c ≤7.0% or with HbA1c >7.0% (2.74% vs. 3.51%, P=0.670) |