BACKGROUND: InspironTM, a chrome-cobalt sirolimus-eluting stent covered by a mixture of bioabsorbable polymers on its abluminal side is being developed in Brazil. Our objective was to compare in an experimental study the findings of optical coherence tomography for the InspironTM and BioMatrix™ stents. METHODS: Stents were implanted in porcine coronary arteries. Each individual received two types of stents, one in each artery (left anterior descending and left circumflex artery). After 28 days, a new angiography was performed and optical coherence tomography was used to assess neointimal hyperplasia. RESULTS: Seven Inspiron™ stents and 7 BioMatrixTM stents were implanted in 7 domestic pigs. The reference diameter of the treated vessels was 2.16 ± 0.37 mm and the balloon to artery ratio was 1.17 ± 0.16 atm, with no statistical difference between groups. In-stent late loss was 0.53 ± 0.56 mm and 0.32 ± 0.37 mm (P = 0.43) for the InspironTM and BioMatrixTM stents, respectively. There was one case of angiographic restenosis in the InspironTM group (14% vs 0; P = 0.2). Optical coherence tomography showed an instent neointimal area of 1.61 ± 0.57 mm² for the InspironTM stent and 1.36 ± 0.66 mm² for the BioMatrixTM stent (P = 0.47). The percentage of neointimal area was 31% for the InspironTM stent vs 23% for the BiomatrixTM stent (P = 0.21). CONCLUSIONS: Twenty-eight days after implantation in porcine coronary arteries the InspironTM stent showed a similar degree of neointimal hyperplasia as the BiomatrixTM stent.
Tomography, optical coherence; Drug-eluting stents; Neointima
