Bailey et al.11 Bailey S, Carmean M, Cinat M, Burton K, Lane C, Malinoski D. A randomized comparison study of Aquacel Ag and Glucan II as donor site dressings with regard to healing time, cosmesis, infection rate, and patient’s perceived pain: a pilot study. J Burn Care Res. 2011;32(6):627-32. DOI: http://dx.doi.org/10.1097/BCR.0b013e31822dc409 http://dx.doi.org/10.1097/BCR.0b013e3182...
|
Sodium carboxymethyl cellulose impregnated with 1.2% silver (Aquacel Ag®) and composed of betaglucan (Glucan II®) |
Pain, healing time, infection rate, and aesthetic result |
20 |
- |
180 days |
Healing time, infection rates, or cosmetic results showed no significant difference; the Aquacel Ag® presented better reduction of the referred pain |
Dornseifer et al.33 Dornseifer U, Lonic D, Gerstung TI, Herter F, Fichter AM, Holm C, et al. The ideal split-thickness skin graft donor-site dressing: a clinical comparative trial of a modified polyurethane dressing and aquacel. Plast Reconstr Surg. 2011;128(4):918-24. PMID: 21681125 DOI: http://dx.doi.org/10.1097/PRS.0b013e3182268c02 http://dx.doi.org/10.1097/PRS.0b013e3182...
|
Sodium carboxymethyl cellulose impregnated with 1.2% silver (Aquacel Ag®) and modified polyurethane (microperforated) |
Re- epithelialization, pain, cost, and aesthetic result |
50 |
- |
60 days |
Modified polyurethane showed better results than Aquacel Ag® at the time of re-epithelialization and producing less referred pain; no statistical difference in aesthetics |
Kaartinen & Kuokkanen1313 Kaartinen IS, Kuokkanen HO. Suprathel(®) causes less bleeding and scarring than Mepilex(®) Transfer in the treatment of donor sites of split-thickness skin grafts. J Plast Surg Hand Surg. 2011;45(4-5):200-3. PMID: 22150140 DOI: http://dx.doi.org/10.3109/2000656X.2011.583515 http://dx.doi.org/10.3109/2000656X.2011....
|
Copolymer of polylactide, trimethylene carbonate and ɛ-caprolactone (Suprathel®) and polyurethane foam (Mepilex® Transfer) |
Healing, pain, and aesthetic result |
22 |
Thighs |
90 days |
Suprathel® produced less pain and bleeding, and better aesthetic results |
Khorasani et al.66 Khorasani G, Ahmadi A, Jalal Hosseinimehr S, Ahmadi A, Taheri A, Fathi H. The Effects of Aloe Vera Cream on Split-thickness Skin Graft Donor Site Management: A Randomized, Blinded, Placebocontrolled Study. Wounds. 2011;23(2):44-8.
|
Gauze with cream base + Aloe vera, gauze with cream base, or gauze only |
Healing and infection |
45 |
Thighs |
- |
Gauze only presented the longest time to heal; however, healing with gauze with cream base was faster than that with gauze with base cream + Aloe vera |
Muangman et al.1414 Muangman P, Nitimonton S, Aramwit P. Comparative clinical study of Bactigras and Telfa AMD for skin graft donor-site dressing. Int J Mol Sci. 2011;12(8):5031-8. DOI: http://dx.doi.org/10.3390/ijms12085031 http://dx.doi.org/10.3390/ijms12085031...
|
Paraffin-impregnated gauze with chlorhexidine (Bactigras®) and gauze impregnated with polyhexamethylene biguanide (Telfa AMD®) |
Re- epithelialization, pain, infection, and cost-benefit |
32 |
Thighs |
- |
Telfa AMD® showed lower healing time, less pain, and lower occurrence of infection; no considerable difference in costeffectiveness was observed among the bandages tested |
Higgins et al.1515 Higgins L, Wasiak J, Spinks A, Cleland H. Split-thickness skin graft donor site management: a randomized controlled trial comparing polyurethane with calcium alginate dressings. Int Wound J. 2012;9(2):126-31. DOI: http://dx.doi.org/10.1111/j.1742-481X.2011.00867.x http://dx.doi.org/10.1111/j.1742-481X.20...
|
Polyurethane (Alle- vyn®) and calcium alginate (Kaltostat®) |
Pain, infection, healing, ease of use, and overall patient satisfaction |
36 |
Thighs, calves, arms and torso |
- |
No significant differences were found between the two dressings in healing time, pain, healing, or patient satisfaction. Allevyn® required more care and changes |
Solanki et al.1616 Solanki NS, Mackie IP, Greenwood JE. A randomised prospective study of split skin graft donor site dressings: AWBAT-D™ vs. Duoderm®. Burns. 2012;38(6):889-98. DOI: http://dx.doi.org/10.1016/j.burns.2011.12.022 http://dx.doi.org/10.1016/j.burns.2011.1...
|
Nylon mesh with silicone membrane and collagen peptides (AWBAT-D®) and hydrocolloid (DuoDERM®) |
Healing and patient comfort |
14 |
- |
- |
Without differences in referred pain, Duoderm® provided re-epithelization in less time. No infections or abnormal scars were found with either product |
Assadian et al.1212 Assadian O, Arnoldo B, Purdue G, Burris A, Skrinjar E, Duschek N, et al. A prospective, randomised study of a novel transforming methacrylate dressing compared with a silver-containing sodium carboxymethylcellulose dressing on partial-thickness skin graft donor sites in burn patients. Int Wound J. 2015;12(3):351-6. DOI: http://dx.doi.org/10.1111/iwj.12136 http://dx.doi.org/10.1111/iwj.12136...
|
Sodium carboxymethyl cellulose impregnated with 1.2% silver and methacrylate transformer |
Referred pain, healing time, and comfort reported |
19 |
Thighs and calves |
24 days |
No statistically significant difference was observed in healing time; however, the methacrylate dressing presented less pain and additional comfort |
Brõlmann et al.99 Brölmann FE, Eskes AM, Goslings JC, Niessen FB, de Bree R, Vahl AC, et al.; REMBRANDT study group. Randomized clinical trial of donor-site wound dressings after split-skin grafting. Br J Surg. 2013;100(5):619-27. DOI: http://dx.doi.org/10.1002/bjs.9045 http://dx.doi.org/10.1002/bjs.9045...
|
Calcium alginate fiber (Kaltostat®), semi-permeable film (Tegaderm®), paraffin- impregnated gauze (Jelonet Adaptic® or®), hydrocolloid (DuoDERM E®), hydrofiber (Aquacel®), and silicone fiber (Mepitel®) |
Time for re- epithelialization, pain, itching, adverse effects, and scarring |
288 |
Thighs, back, arms |
90 days |
DuoDERM E® provided complete re- epithelialization faster (7 days) than any other, while the pain was lower with Tegaderm®. The infection was twice as big when Adaptic® or Jelonet® was used, and Tegaderm® appeared less likely to cause scarring |
Davidson et al.1717 Davidson A, Jina NH, Marsh C, Than M, Simcock JW. Do functional keratin dressings accelerate epithelialization in human partial thickness wounds? A randomized controlled trial on skin graft donor sites. Eplasty. 2013;13:e45.
|
Calcium alginate fiber (Algisite®) and keratin- rich absorbable fiber (Keramatrix®) |
Time for re- epithelialization, ease, and pain during handling |
26 |
Thighs |
7 days |
Young patients showed an 80% rate of re- epithelialization in 7 days as compared with 5% in older patients; the effect of Keramatrix® was statistically faster in young patients, with no significant difference in older patients |
Ding et al.1818 Ding X, Shi L, Liu C, Sun B. A randomized comparison study of Aquacel Ag and Alginate Silver as skin graft donor site dressings. Burns. 2013;39(8):1547-50. DOI: http://dx.doi.org/10.1016/j.burns.2013.04.017 http://dx.doi.org/10.1016/j.burns.2013.0...
|
Sodium carboxymethyl cellulose impregnated with 1.2% silver (Aqua- cel Ag®) and calcium alginate film and silver (Silver Alginate®) |
Time for re- epithelialization, pain, infection rate, and aesthetic result |
20 |
Back, thighs, and chest |
180 days |
Patients treated with Aquacel Ag® showed higher pain levels and longer re-epithelialization rates; no significant differences were found in infection rates or aesthetic results |
Hassanpour et al.1919 Hassanpour SE, Moosavizadeh SM, Yavari M, Hallaj Mofrad HR, Fadaei A. Comparison of three different methods of dressing for partial thickness skin graft donor site. World J Plast Surg. 2013;2(1):26-32.
|
Paraffin-impregnated gauze, nitrofurazone- and paraffin- impregnated gauze, and dry gauze |
Rates of healing, pain, discharge, infection, and cost |
60 |
Thighs |
21 days |
Nitrofurazone- and paraffin-impregnated gauze provided re-epithelization significantly faster with less pain and secretions. No significant differences were found in cost among the three treatments |
Healy et al.2020 Healy C, Greig AV, Murphy AD, Powell C, Pinder RJ, Saour S, et al. Prospective randomized controlled trial: fibrin sealant reduces split skin graft donor-site pain. Plast Reconstr Surg. 2013;132(1):139e-46e. PMID: 23806933 DOI: http://dx.doi.org/10.1097/PRS.0b013e318299c6f4 http://dx.doi.org/10.1097/PRS.0b013e3182...
|
Self-adhesive mesh (Mefix®) and selfadhesive fabric (Mefix®) + fibrin sealant spray |
Pain and disability |
40 |
Thighs |
14 days |
Patients treated with selfadhesive mesh (Mefix®) + fibrin sealant spray showed significantly lower rates of pain and disability |
Kaiser et al.2121 Kaiser D, Hafner J, Mayer D, French LE, Läuchli S. Alginate dressing and polyurethane film versus paraffin gauze in the treatment of split-thickness skin graft donor sites: a randomized controlled pilot study. Adv Skin Wound Care. 2013;26(2):67-73. DOI: http://dx.doi.org/10.1097/01.ASW.0000426715.57540.8d http://dx.doi.org/10.1097/01.ASW.0000426...
|
Paraffin-impregnated gauze (Bactigras®) covered with gauze and alginate film (Algisite M®) covered with transparent polyurethane mesh (OpSite Flexigrid®) |
Referred pain, dressing changes, healing time, aesthetic results, cost, and patient satisfaction |
30 |
- 180 days |
No statistically significant differences were found, but the paraffin- impregnated gauze group showed a lower cost |
Lauchli et al.2222 Läuchli S, Hafner J, Ostheeren S, Mayer D, Barysch MJ, French LE. Management of split-thickness skin graft donor sites: a randomized controlled trial of calcium alginate versus polyurethane film dressing. Dermatology. 2013;227(4):361-6. PMID: 24281776 DOI: http://dx.doi.org/10.1159/000356122 http://dx.doi.org/10.1159/000356122...
|
Calcium alginate fiber (Kaltostat®) and transparent film of polyurethane (OpSite Flexigrid®) |
Referred pain, re- epithelialization time, dressing changes, and complications |
38 |
Thighs |
41 days |
OpSite Flexigrid® caused significantly less pain but demanded more frequent dressing changes and involved leakage problems |
Malin et al.2323 Malin EW, Galin CM, Lairet KF, Huzar TF, Williams JF, Renz EM, et al. Silver-coated nylon dressing plus active DC microcurrent for healing of autogenous skin donor sites. Ann Plast Surg. 2013;71(5):481-4. DOI: http://dx.doi.org/10.1097/SAP.0b013e31829d2311 http://dx.doi.org/10.1097/SAP.0b013e3182...
|
Nylon mesh and silver with microcircuit device active and inactive (placebo) |
Referred pain, re-epitheliza- tion, and signs of infection |
25 |
Thighs |
15 days |
No statistically significant differences |
Raza et al.2424 Raza MS, Nazim T, Khan FA. Comparison of bupivacaine moistened dressing and conventional dressing for pain relief on skin graft donor sites. J Coll Physicians Surg Pak. 2014;24(6):416-9.
|
0.25% bupivacaine hydrochloride and saline solution |
Pain |
150 |
- |
1 day |
Need for analgesia in 6.7% of patients treated with 0.25% bupivacaine hydrochloride and in 96% of patients treated with saline solution |
Tanaka et al.2525 Tanaka K, Akita S, Yoshimoto H, Houbara S, Hirano A. Lipidcolloid dressing shows improved reepithelialization, pain relief, and corneal barrier function in split-thickness skin-graft donor wound healing. Int J Low Extrem Wounds. 2014;13(3):220-5. DOI: http://dx.doi.org/10.1177/1534734614541544 http://dx.doi.org/10.1177/15347346145415...
|
Non-adherent polyester (Trex-C®) and nonadherent petrolatum- and hydrocolloid (Hurgotul®)- impregnated polyester |
Pain and re- epithelialization |
10 |
Thighs |
30 days |
The petrolatum- and hydrocolloid- impregnated polyester dressing presented better healing and pain relief than the nonadherent conventional polyester |
Dhanraj22 Dhanraj P. A Clinical Study Comparing Helicoll with Scarlet Red and OpSite in the Treatment of Split Thickness Skin Graft Donor Sites-A Randomized Controlled Trial. Indian J Surg. 2015;77(Suppl 2):385-92. DOI: http://dx.doi.org/10.1007/s12262-013-0850-3 http://dx.doi.org/10.1007/s12262-013-085...
|
Film of collagen type-1 (Hellicol®), transparent film of polyurethane (OpSite®), and petrolatum film impregnated with Scarlet Red®
|
Pain, healing time, initial dressing uptake, and infection rate |
30 |
Thighs |
90 days |
Helicoll® provided significantly less pain, lower infection rate, and less need for dressing changes in addition to a shorter healing time than Scarlet Red® and was comparable with OpSite®
|
Hasatsri et al.2626 Hasatsri S, Angspatt A, Aramwit P. Randomized Clinical Trial of the Innovative Bilayered Wound Dressing Made of Silk and Gelatin: Safety and Efficacy Tests Using a Split-Thickness Skin Graft Model. Evid Based Complement Alternat Med. 2015;2015:206871. PMID: 26221170 DOI: http://dx.doi.org/10.1155/2015/206871 http://dx.doi.org/10.1155/2015/206871...
|
Dressing of two layers of silk and gelatin, and paraffin-impregnated gauze (Bactigras®) |
Healing time, pain, barrier function, and systemic reaction |
23 |
Thighs |
150 days |
The dressing with two layers of silk and gelatin showed significantly better results than Bactigras® in terms of healing time and recovery of the barrier function of the skin and pain reduction |
|
|
Presence of serous, |
|
|
|
|
Jorge et al.55 Jorge JLG, Naif C, Marques EGSC, Andrade GAM, Lima RVKS, Müller Neto BF, et al. Malha de algodão parafinado versus malha de fibra de celulose salinizada como curativo temporário de áreas doadoras de pele parcial. Rev Bras Queimaduras. 2015;14(2):103-8.
|
Salinized cellulose fiber fabric (Rayon®) and paraffin- impregnated gauze (Jelonet®) |
bleeding, signs of infection, flushing location, offset of the bandage, complete re- epithelialization, and referred pain |
37 |
Thighs and scalp |
15 days |
Jelonet® promoted less pain and faster re- epithelialization |
Salehi et al.2727 Salehi SH, As’adi K, Mousavi SJ, Shoar S. Evaluation of Amniotic Membrane Effectiveness in Skin Graft Donor Site Dressing in Burn Patients. Indian J Surg. 2015;77(Suppl 2):427-31. PMID: 26730039 DOI: http://dx.doi.org/10.1007/s12262-013-0864-x http://dx.doi.org/10.1007/s12262-013-086...
|
Amniotic membrane and petroleum jelly-impregnated gauze |
Healing, pain, and infection rate |
42 |
Thighs and other |
- |
The amniotic membrane provided a significantly faster healing and less reported pain, but no significant differences in infection rates |
Subrahmanyam10
|
Honey-impregnated gauze and petroleum jelly-impregnated gauze |
Pain, leakage of exudate, cutaneous reactions, re- epithelization, and aesthetic results |
100 |
Thighs |
30 days |
Re-epithelization occurred significantly faster in patients treated with the honey- impregnated gauze, with no significant differences in relation to referred pain or allergic reactions between the groups |
Akita et al.2828 Akita S, Yoshimoto H, Tanaka K, Oishi M, Senju C, Mawatari S, et al. Silver Sulfadiazine-Impregnated Hydrocolloid Dressing Is Beneficial in Split-Thickness Skin-Graft Donor Wound Healing in a Small Randomized Controlled Study. Int J Low Extrem Wounds. 2016;15(4):338-43. DOI: http://dx.doi.org/10.1177/1534734616670988 http://dx.doi.org/10.1177/15347346166709...
|
Hydrocolloid (DuoDERM CGF®) and silver sulfadiazineimpregnated hydrocolloid (Biohesive Ag®) |
Re- epithelialization, pain, ease of handling, bleeding, and grip |
14 |
Thighs |
180 days |
Silver sulfadiazineimpregnated hydrocolloid provided significantly higher healing, reduced the degree of bleeding, and demonstrated better barrier function and aesthetic results |
Schulz et al.88 Schulz A, Depner C, Lefering R, Kricheldorff J, Kästner S, Fuchs PC, et al. A prospective clinical trial comparing Biobrane(®) Dressilk(®) and PolyMem(®) dressings on partial-thickness skin graft donor sites. Burns. 2016;42(2):345-55. DOI: http://dx.doi.org/10.1016/j.burns.2014.12.016 http://dx.doi.org/10.1016/j.burns.2014.1...
|
Nylon fabric coated with collagen type I (Biobrane®), silk mesh with fibrin (Dressilk®) and a hydrophilic polyurethane membrane (PolyMem®) |
Pain, curative transparency, active bleeding, exudation, and inflammation |
28 |
Thighs |
180 days |
No significant differences were found among the three dressings in terms of pain, re-epithelization, or bleeding. PolyMem® presented the below results regarding the reduction of inflammation and exudation in relation to patient comfort |