El-Zawahry, 201577. El-Zawahry BM, Sobhi RM, Bassiouny DA, Tabak SA. Ablative CO2 fractional resurfacing in treatment of thermal burn scars: an open-label controlled clinical and histopathological study. J Cosmet Dermatol. 2015;14(4):324-31. DOI: http://dx.doi.org/10.1111/jocd.12163 http://dx.doi.org/10.1111/jocd.12163...
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11 |
Before sessions of fractional CO2 laser X After treatment |
3 sessions, DEKA, 30w, 800-μm spacing, 800-μs dwelling time, stack 1 |
VSSa POSASb
|
Hypertrophic scars showed improvement in texture and significant decreases in Vancouver score and POSAS. |
p = 0.011 (VSS) p = 0.017 (POSAS observer score) p = 0.180 (POSAS patient score |
Azzam, 201533. Azzam OA, Bassiouny DA, El-Hawary MS, El Maadawi ZM, Sobhi RM, El-Mesidy MS. Treatment of hypertrophic scars and keloids by fractional carbon dioxide laser: a clinical, histological, and immunohistochemical study. Lasers Med Sci. 2016;31(1):9-18. DOI: http://dx.doi.org/10.1007/s10103-015-1824-4 http://dx.doi.org/10.1007/s10103-015-182...
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7 |
Half of the scar treated with fractional CO2 laser X Half of the scar left untreated |
4 sessions with 6-week intervals; DEKA; 25w; stack 3; 600-μs dwelling time; 700–800 spacinghypertrophic keloid: 30w; stack 4; 1000 μs; 800 spacing |
VSS |
The VSS score was significantly lower in the treated scar halves than in the untreated scar halves. |
p = 0.042 (after 3 months) p = 0.027 (after 6 months) |
Makboul, 201455. Makboul M, Makboul R, Abdelhafez AH, Hassan SS, Youssif SM. Evaluation of the effect of fractional CO2 laser on histopathological picture and TGF-â1 expression in hypertrophic scar. J Cosmet Dermatol. 2014;13(3):169-79. DOI: http://dx.doi.org/10.1111/jocd.12099 http://dx.doi.org/10.1111/jocd.12099...
|
40 |
Before sessions of fractional CO2 laser X After treatment |
4 sessions with 1-month intervals; ATL 250 CO2 medical laser system; 25 w; time on = 1 ms; pixels per inch = 6 |
VSS |
A statistically significant difference in the VSS score was found between before and after the fractional CO2 laser treatment. |
p > 0.001 (VSS) |
Drooge, 20151111. van Drooge AM, Vrijman C, van der Veen W, Wolkerstorfer A. A randomized controlled pilot study on ablative fractional CO2 laser for consecutive patients presenting with various scar types. Dermatol Surg. 2015;41(3):371-7. DOI: http://dx.doi.org/10.1097/DSS.0000000000000306 http://dx.doi.org/10.1097/DSS.0000000000...
|
12 |
Half of the scar treated with fractional CO2 laser X Half of the scar left untreated |
3 sessions with 8-week intervals; UltraPulse Encore - Lumenis Inc, Santa Clara, CA - spot diameter 120 μm, 600 Hz, 30–40 mJ |
POSAS GPAc
|
GPA showed no statistically significant difference between the treated and untreated sides of the scar. Statistical analysis revealed no significant difference in POSAS score between the two sides of the scar. |
p = 0.70 (GPA at 6 months) p = 0.09 (POSAS) |
Choi, 20131212. Choi JE, Oh GN, Kim JY, Seo SH, Ahn HH, Kye YC. Ablative fractional laser treatment for hypertrophic scars: comparison between Er:YAG and CO2 fractional lasers. J Dermatolog Treat. 2014;25(4):299-303. DOI: http://dx.doi.org/10.3109/09546634.2013.78 2090 http://dx.doi.org/10.3109/09546634.2013....
|
10 |
Before sessions of fractional CO2 laser X After treatment |
1–9 sessions with 4- to 8- interval; Lutronic Corp, Korea; 40–60 mJ; 150 spots/cm2 |
VSS 5-point rating scale |
Flexibility and scar height significantly improved, while the improvements in vascularization and pigmentation were negligible. |
49.8% (change in VSS) 51% (flexibility) 75% (height) |
Lei, 20171313. Lei Y, Li SF, Yu YL, Tan J, Gold MH. Clinical efficacy of utilizing Ultrapulse CO2 combined with fractional CO2 laser for the treatment of hypertrophic scars in Asians-A prospective clinical evaluation. J Cosmet Dermatol. 2017;16(2):210-6. DOI: http://dx.doi.org/10.1111/jocd.12334 http://dx.doi.org/10.1111/jocd.12334...
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15 8 |
Before the fractional CO2 laser sessions X After treatment |
3 sessions with 3-month intervals; UltraPulse Encore Lumenis, Yokneam, Israel; 150–175 mJ, 40 Hz; distance between spots 3–5 mm |
VSS UNCd patient satisfaction survey |
VSS and UNC scores showed statistically significant differences from before to after fractional CO2 laser treatment. |
p < 0.0001 (VSS) p < 0.0001 (UNC) |
Hultman, 20141414. Hultman CS, Friedstat JS, Edkins RE, Cairns BA, Meyer AA. Laser resurfacing and remodeling of hypertrophic burn scars: the results of a large, prospective, before-after cohort study, with long-term follow-up. Ann Surg. 2014;260(3):519-29.
|
14 7 |
Before sessions of fractional CO2 laser X After treatment |
2–6 sessions with 4- to 6-week intervals; Lumenis UltraPulse, Santa Clara, CA |
VSS UNC4Pe |
Fractional CO2 laser treatment resulted in significant improvements in the scars. |
p < 0.001 (VSS) p < 0.001 (UNC4P) |