INTRODUCTION: CO2 infusion-controlled restores granulation tissue in chronic venous caused by venous insufficiency of the lower limbs, becoming ready to receive autologous skin grafting. METHODS: Mean time of ulceration was 12.5 months. CO2 infusion-controlled was applied 0.5 cm from the wound edge. Punctures were done 2.5 cm distant from each other along the border of the wound with the needle pointed toward the granulation tissue. Biopsies were taken from the granulation tissue before and after CO2 application. The sessions were performed at intervals of 72 hours. RESULTS: Noticeable increase of capillaries, macrophages and fibroblasts were founded into the granulation tissue after CO2 infusion-controlled. Diameter of pre-capillary arterioles increased 3.4 times after CO2 infusion-controlled. CONCLUSION: CO2 infusion-controlled restores the blood flow in chronic wound of the lower limbs, promoting its spontaneous closure or improving granulation tissue ready to receive autologous skin grafting.
Carbon Dioxide; Vasodilatation; Leg Ulcer; Ulcer
