| 1. Kalil et al. (2015)1212 Kalil CLPV, Frainer RH, Dexheimer LS, Tonoli RE, Boff AL. Tratamento das cicatrizes de acne com a técnica drug delivery. Surg Cosmet Dermatol. 2015;7(2):144-8.
|
Treatment of acne scars with the microneedling technique and drug delivery |
Sterile Dr. Roller® device;
192
2mm needles;
Three sessions
interval of
one to two months
between sessions. |
Atrophic scars of moderate to severe acne on the face. The rollers directed in a horizontal and oblique position, imitating the shape of the wind rose, with ten repetitions in each direction |
Applying a mask; EGF - Epidermal growth factor 1%,
IGF - Insulin growth factor 1%, TGFβ3 - Transforming growth factor 1%, Hyaluronic acid 0.5%, Acid
0.5% tranexamic,
Vitamin E 2%, Portulaca extract 1%, Gel
mask containing growth factor.
Dermomax® topical anesthetic for 60 min. |
Did not associate; Edema and Erythema. |
Pre- and post-procedure photos. Skin biopsy before and after 30 days of treatment. |
Eight patients completed the study. Overall improvement in the appearance of the skin and slight improvement of distensible atrophic scars. Atrophic scars like ice picks did not improve with the procedure. |
Modest improvement of atrophic scars; ice picks atrophic scars showed no improvement with the procedure. |
2. Kalil et al.
(2015)1313 Kalil CLP, Campos VB, Chaves CRP, Pitassi LHU, Cignachi S. Estudo comparativo, randomizado e duplo-cego do microagulhamento associado ao drug delivery para rejuvenescimento da pele da região anterior do tórax. Surg Cosmet Dermatol. 2015;7(3):211-6.
|
Randomized, double-blind comparative study of microneedling associated with drug delivery to rejuvenate the skin of the anterior chest |
Dr.Roller®; 192 needles
0.07mm surgical steel
thickness and 1.5mm in
length. 3, with
monthly interval. |
Anterior region
of the chest. With
minimal
45 º angle pressure,
ten spreading
movements in
four directions:
horizontal, vertical,
diagonal right,
and left. |
Juvenile® 2%;
Phytocelltec Malus
Domestic® 0.5%;
Cell to Cell® 2%;
Homeostatine ®;
Hyaluronic Acid
2.5%; Fluid Anhydrous
Serum
q.s.p 30.
Anesthetic cream
topic. |
Home application of the same product, or
the placebo, with gentle massages with the fingers until complete absorption 1x a day, at night Phenol Peeling 88%, before microneedling; No adverse effects were observed in the treated patients. |
Pre and post 30-day evaluation of the procedure through photography, performed by a dermatologist unrelated to the study, and by applying self-assessment questionnaires by patients. |
Twenty-two patients, three months of treatment, 100% improvement of patients; 28% improvement in overall rejuvenation with the use of the test product compared to placebo. Improvement
30% in patients treated with the use of microneedling and test product on skin texture, smoothness and firmness |
To obtain results for advanced global rejuvenation, it is necessary to add specific actives for drug delivery.
Significant improvement in overall appearance, demonstrating a well-tolerated procedure, with minimal adverse effects and a high patient satisfaction index |
| 3. Lima (2015)77 Lima EA. Associação do microagulhamento ao peeling de fenol: uma nova proposta terapêutica em flacidez, rugas e cicatrizes de acne da face. Surg Cosmet Dermatol. 2015;7(4):328-31.
|
Association
between microneedling
and phenol
peeling: a new
t h e rapeutic
proposal
for sagging,
wrinkles, and
acne scars on
the face.
Periorbital
wrinkle treatments
by
collagen induction
therapy |
Instrument with 192 2.5mm needles, arranged in 8 rows, DR Roller® one session. |
Face
Back and forth
movements until
obtaining uniform
bloody dew.
Periorbital wrinkles.
Rolling the
device
back and forth,
with the same
pressure;
horizontally,
vertically and
diagonally to the
right and left. |
Skin regenerator 3x a day; industrialized depigmenting agent (0.05% retinoic acid,
Hydroquinone 4%, fluocinolone acetonide 0.01%), alternating with the skin regenerator for 15 days; sunscreen with protection factor 50.
Anesthetic block of infraorbital and mentonian nerves, followed by infiltrative anesthesia with
2% lidocaine solution. |
Patient B also had
as adjunctive treatment
lymphatic
drainage and regular
physical activities.
Patients A and
D had only physical
activity, C and E did
not undergo physical
activity during
the follow-up;
Erythema, edema,
post-inflammatory
hyperpigmentation,
and infections |
A clinical and photographic evaluation was performed by the investigator three months after the procedure, using a scale with the items very good, good, reasonable, and bad. Patient satisfaction questionnaires were also applied. |
Twenty-eight patients were treated; 12 of them had wrinkles and sagging, five only acne scars, and ten patients with wrinkles, sagging, and acne scars. Result from good to very good; 100% of patients reported satisfaction with the results. |
It can produce improvement
in the quality
of the skin, attenuating
wrinkles and correcting
depressed acne scars.
The procedure of the
evaluated group presented
an excellent safety
profile;
The addition of 88% phenol
before microneedling
enhances the results for
acne, sagging, and ritid
scarring treatments. |
4.
Fabbrocini
et al. (2009)1111 Fabbrocini G, Padova MP, Vita V, Fardella N, Pastore F, Tosti A. Tratamento de rugas periorbitais por terapia de indução de colágeno. Surg Cosmet Dermatol. 2009;1(3):106-11.
|
Periorbital wrinkle treatments by collagen induction therapy |
Rolling cylinder 20mm wide, with 192 needles in eight rows, 1.5mm long and 0.25mm in diameter, according to the applied penetration, they were introduced into the skin from 0.1 to 1.3mm. 2 sessions with an interval of 8 weeks between them |
Periorbital wrinkles.
Rolling the
device
back and forth,
with the same
pressure;
horizontally,
vertically and
diagonally to the
right and left. |
Did not use; Topical anesthesia (EMLA applied and left for 60 min). |
Did not describe; Redness and swelling. |
The evaluation was
based on photographs
taken on a digital
camera and images
computerized. Silicone
rubber molds were
used to assess the
depth of the wrinkles
and print their micro-
-relief. |
Eight weeks after the first CIT session, all patients had smoother skin,
a slight reduction in the severity of injuries and minimal aesthetic improvement; thirty-two weeks after the second session of CIT, the improvement of periorbital wrinkles was evident. |
It shows that CIT is a
simple technique and
that with a specialized
tool you can
have an "immediate
effect" on improving
periorbital wrinkles. The
degree of severity of
periorbital wrinkles after
just two sessions were highly
reduced, and overall
aesthetic improvement
was also remarkable. |
5. Contin
(2016)44 Contin LA. Alopecia androgenética masculina tratada com microagulhamento isolado e associado a minoxidil injetável pela técnica de microinfusão de medicamentos pela pele. Surg Cosmet Dermatol. 2016;8(2):158-61.
|
Male androgenetic alopecia was treated
with microneedling isolated and associated
injectable minoxidil using the skin micro-infusion technique. |
Cylinders with needles,
which produce punctures
1.5 mm deep;
Tattoo machine with 17
microneedles
in a row(MMP). Case 1: 4
monthly sessions; Case 2:
3 sessions. |
Scalp. Moves back and forth until a bleeding dew is produced. |
Case 1: Minoxidil 0.5%; neutral shampoo; simple painkillers;
Case 2:
Microneedling without drug infusion. Lidocaine 4% cream. |
Gentle washing with neutral shampoo six hours after the procedure and use of simple painkillers if there is local pain.
Ache |
Photographic record before the procedure and one month after the last session. |
Partial and satisfactory response in both cases, one of them had the infiltration of minoxidil and the other only to the microneedling process. |
Partial and satisfactory response in both cases. |
