Chemical and biological aspects of octocorals from the Brazilian coast

Almeida, Maria Tereza R.; Moritz, Maria Izabel G.; Capel, Katia C.C.; Pérez, Carlos D.; Schenkel, Eloir P.

doi:10.1016/j.bjp.2014.05.002

Maria Tereza R. Almeida ^**Corresponding author. E-mail: tereza.rojo@posgrad.ufsc.br (M.T.R. Almeida).

Departamento de Ciências Farmacêuticas, Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil

Maria Izabel G. Moritz

Departamento de Ciências Farmacêuticas, Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil

Katia C.C. Capel

Centro de Biologia Marinha, Universidade de São Paulo, São Sebastião, SP, Brazil

Carlos D. Pérez

Grupo de Pesquisa em Antozoários, Universidade Federal de Pernambuco, Centro Acadêmico de Vitória, Vitória de Santo Antão, PE, Brazil

Eloir P. Schenkel

Departamento de Ciências Farmacêuticas, Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil

*Corresponding author. E-mail: tereza.rojo@posgrad.ufsc.br (M.T.R. Almeida).

Conflicts of interest

The authors declare no conflicts of interest.

Authors' contributions

MTRA (Postdoctoral student) contributed with the concept, design, and arrangement of the present review article, including data collection, selection of papers and writing of the sections related to natural products. MIGM (PhD student) contributed with data collection, writing of the sections related to natural products and formatting of the manuscript. KCCC (PhD student) contributed with data collection, selection of papers and thesis and writing of the sections related to taxonomical aspects. CDP contributed with expertise related to taxonomic aspects and critical reading of the draft manuscript. EPS supervised the process of drafting and contributed in finalizing the article through critical reading of the draft manuscript. All the authors have read the final manuscript and approved submission. MTRA, MIGM and KCCC contributed equally to this work.

Species	Extracts/Compounds	Biological activities	References
Carijoa riisei^a a Reef species.	polyoxygenated steroids, sterol glycosides	cytotoxicity	Maia et al., 2000
	punaglandins	antiproliferative	Baker and Scheuer, 1994; Baker et al., 1994; Verbitski et al., 2004
	pregnanes	antileishmanial	Maia et al., 1998; Almeida et al., 2012
	amides, polyoxygenated steroids	cytotoxicity	Liyanage and Schmitz, 1996
	18-acetoxypregna-1,4,20-trien-3-one	cytotoxicity, antileishmanial	Seleghim et al., 2007; Kossuga et al., 2007; Ross and Scheuer, 1979; Reimão et al., 2008
	carotenoids	-	Maia et al., 2013
Chromonephthea brazíliensis	23-ketocladiellin-A	feeding deterrent	Fleury et al., 2008
	polyenes	-	Maia et al., 2011b
	extract	feeding deterrent	Lages et al., 2006
	extracts	genotoxicity	Carpes et al., 2013
Convexella magelhaenica	dolabellane diterpenoids	cytotoxicity	Almeida et al., 2010
Dasystenella acanthina	sesquiterpenoids, polyoxygenated steroids	-	Mellado et al., 2004; Gavagnin et al., 2003
Heterogorgia uatumani^a a Reef species.	eunicellane diterpenoid, sesquiterpene lactone, heterogorgiolide	feeding inhibition	Maia et al., 1999
Leptogorgia punicea^a a Reef species.	hidroquinone, steroids, punicin		Epifanio et al., 1998
	carotenoids	-	Maia et al., 2013
Leptogorgia setacea	pukalide 11β,12β-epoxypukalide	antifouling, feeding deterrent	Ksebati et al., 1984; Gerhart et al., 1988; Gerhart et al., 1993
	homarine	antifouling, antimicrobial	Targett et al., 1983; Shapo et al., 2007
	polyenals	-	Maia et al., 2013
Leptogorgia violacea (E)^a a Reef species.	lophotoxin, deoxylophotoxin, 13-acetoxy-11β,12β-epoxypukalide, furanocembranolides	feeding deterrent	Epifanio et al., 2000
	polyenals	-	Maia et al., 2011b
Muricea atlântica	carotenoids	-	Maia et al., 2013
Muricea flamma	polyenals	-	Maia et al., 2013
Muriceopsis flavida	steroids, sesquiterpenes	antimicrobial	Kokke et al., 1982; Liu et al., 2012; 2011
	steroids	antiproliferative	Liu et al., 2013
Neospongodes atlantica (E)^a a Reef species.	crude extract	feeding stimulation	Epifanio et al., 1999
Nicela goreauii	crude extract	feeding deterrent	O'Neal and Pawlik, 2002
Phyllogorgia dilatata (E)^a a Reef species.	steroids	-	Kelecom et al., 1980
	diterpene epoxypukalide,
	germacrane sesquiterpene	antipredatory, antifouling	Epifanio et al, 1999; 2006; Martins and Epifanio, 1998
	nardosinane sesquiterpene	-	Kelecom et al., 1980; Fernandes and Kelecom, 1995
	crude extract	antifouling	Pereira et al., 2002
	polyenals, carotenoids	-	Maia et al., 2011a; 2013
	peptide	antimicrobial	De Lima et al., 2013
Plexaurella dichotoma^a a Reef species.	cetylpalmitate	-	Rodríguez et al., 1983
	eicosatetraenoic acid	-	Di Marzo et al., 1996
	muurolene sesquiterpene, bisbolene	-	Weinheimer et al., 1967
Plexaurella regia (E)^a a Reef species.	crude extract	feeding stimulation	Epifanio et al., 1999
Renilla reniformis	briarane-type diterpenes	antifouling, feeding deterrent	Rueda et al., 2001; Barsby and Kubanek, 2005
	extracts	feeding deterrent	Clavico et al., 2013
Renilla muelleri	polyenals	-	Maia et al., 2013
	extracts	feeding deterrent	Clavico et al., 2013
Swiftia exerta	glycosylated pregnene	-	Wright et al., 2004
Tripalea clavaria	secosteroids	antimicrobial	Rodríguez Brasco et al., 2007

[TFN01t01] E, endemic in Brazil.

[TFN02t01] ^a
Reef species.