Two new diterpenoids from <i>Leonurus
                    japonicus</i>

Wu, Hankui; Wang, Sensheng; Liu, Haijuan; E, Yan; Li, Yan; Liu, Ruijin; Wang, Jinjin; Xu, Zhiyong; Lv, Yanyan; Sun, Shanshan; Li, Gang; Shi, Yunfeng

doi:10.1016/j.bjp.2015.02.006

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Short Communications • Rev. bras. farmacogn. 25 (2) • Mar-Apr 2015 • https://doi.org/10.1016/j.bjp.2015.02.006 copy

Two new diterpenoids from Leonurus japonicus

Authorship SCIMAGO INSTITUTIONS RANKINGS

Abstract

Two new labdane-type diterpenoids, 5-ethoxy-3-(2-((R)-4-hydroxy-2,5,5,8a-tetramethyl-3-oxo-3,5,6,7,8,8a-hexahydronaphthalen-1-yl)ethyl)furan-2(5H)-one (1), and 5-hydroxy-4-(2-((1R,3S,7aS)-1-hydroxy-4,4,7a-trimethyl-3-propionyloctahydroisobenzofuran-1-yl)ethyl)furan-2(5H)-one (2), were isolated from the EtOH extract of the herb of Leonurus japonicus Houtt., Lamiaceae. Their chemical structures were determined by analysis of 1D, 2D NMR, HRESIMS, and by comparison with known analogs.

Keywords:
Leonurus japonicus ; Labdane diterpenoid

Position	1		2
	ΔC	ΔH	ΔC	ΔH
1	29.4	1.50 (m), 2.05 (m)	30.7	1.40 (m), 1.60 (m)
2	17.1	1.69 (m), 1.87 (m)	18.9	1.58 (m), 1.68 (m)
3	37.2	1.90 (m)	41.1	1.18 (m), 1.45 (m)
4	35.7		32.1
5	140.6		54.0	2.54 (d, 11.6)
6	143.1		83.5	4.40 (d, 11.6)
7	181.5		211.5
8	127.9		31.6	2.77 (q, 7.2)
9	164.3		109.8
10	43.9		48.9
11	28.4	2.51 (m), 2.64 (m)	30.4	1.74 (m); 2.15 (m)
12	24.3	2.46 (m)	21.5	2.95 (m), 2.83 (m)
13	137.4		167.1
14	142.4	6.88 (br s)	112.9	5.91 (d, 2.0)
15	101.6	5.84 (br s)	170.8
16	170.9		97.3	6.19 (s)
17	11.5	1.98 (s)	6.9	1.06 (t, 7.2)
18	28.0	1.38 (s)	33.1	0.79 (s)
19	27.7	1.38 (s)	22.2	1.07 (s)
20	27.8	1.38 (s)	16.2	1.09 (s)
-OH		6.96 (s)
O-CH₂-CH₃	65.2	3.84 (m)
O-CH₂-CH₃	14.5	1.29 (m)

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[1] *Corresponding authors. E-mails:hkwu@aynu.edu.cn (H. Wu), ligang@aynu.edu.cn (G. Li), yfshi@aliyun.com (Y. Shi).