Rhizome |
Methanol |
Anti-inflammatory and antinociceptive effects |
Zakaria et al. (2010)Zakaria, Z.A., Mohamad, A.S., Chear, C.T., Wong, Y.Y., Israf, D.A., Sulaiman, M.R., 2010. Antiinflammatory and antinociceptive activities of Zingiber zerumbet methanol extract in experimental model systems. Med. Princ. Pract. 19, 287-294.
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Rhizome |
Chloroform |
Antimicrobial activity |
Phongpaichit et al. (2006)Phongpaichit, S., Vuddhakul, V., Subhadhirasakul Wattanapiromsakul, C., 2006. Evaluation of the antimycobacterial activity of extracts from plants used as self-medication by AIDS patients in Thailand. Pharm. Biol. 44, 71-75.
|
Rhizome |
Chloroform |
Antimicrobial activity against methicillin-resistant S. aureus
|
Voravuthikunchai et al. (2006)Voravuthikunchai, S.P., Limsuwan, S., Supapol, O., Subhadhirasakul, S., 2006. Antibacterial activity of extracts from family Zingiberaceae against foodborne pathogens. J. Food. Safety. 26, 325-334.
|
Rhizome |
Ethanol |
Antimalarial activity |
Sriphana et al. (2013)Sriphana, U., Pitchuanchom, S., Kongsaeree, P., Yenjai, C., 2013. Antimalarial activity and cytotoxicity of zerumbone derivatives. Sci. Asia 39, 95-99.
|
Rhizome |
Chloroform |
Activity against Epstein–Barr virus early antigen |
Vimala et al. (1999)Vimala, S., Norhanom, A.W., Yadav, M., 1999. Anti-tumour promoter activity in Malaysian ginger rhizobia used in traditional medicine. Br. J. Cancer 80, 110-116.
|
Commercial |
Zerumbone |
Antiproliferative and anti-inflammatory Effects |
Takada et al. (2005)Takada, Y., Murakami, A., Aggarwal, B.B., 2005. Zerumbone abolishes NF-jB and IjBa kinase activation leading to suppression of antiapoptotic and metastatic gene expression, upregulation of apoptosis, and downregulation of invasion. Oncogene 24, 6957-6969.
|
Rhizome |
Zerumbone |
Anti-inflammatory and anticarcinogenic activity |
Murakami et al. (2002)Murakami, A., Takahashi, D., Kinoshita, T., Koshimizu, K., Kim, H.W., Yoshihiro Nakamura, Y., Jiwajinda, S., Terao, J., Ohigashi, H., 2002. Zerumbone, a Southeast Asian ginger sesquiterpene, markedly suppresses free radical generation, pro-inflammatory protein production, and cancer cell proliferation accompanied by apoptosis: the α,β-unsaturated carbonyl group is a prerequisite. Carcinogenesis 23, 795-802.
|
Rhizome |
Zerumbone |
Activity against liver cancer |
Taha et al. (2010)Taha, M.M.E., Abdul, A.B., Abdullah, R., Ibrahim, T.A.T., Abdelwahab, S.I., Mohan, S., 2010. Potential chemoprevention of diethylnitrosamine-initiated and 2-acetylaminofluorene-promoted hepatocarcinogenesis by zerumbone from the rhizomes of the subtropical ginger (Zingiber zerumbet). Chem. Biol. Interact. 186, 295-305.
|
Rhizome |
Zerumbone |
Activity against ovarian and cervical cancer |
Abdelwahab et al. (2012)Abdelwahab, S.I., Abdul, A.B., Zain, Z.N.M., Hadi, A.H.A., 2012. Zerumbone inhibits interleukin-6 and induces apoptosis and cell cycle arrest in ovarian and cervical cancer cells. Int. Immunopharmacol. 12, 594-602.
|
Rhizome |
Diethyl ether |
Antitumor effects |
Huang et al. (2005)Huang, G., Chien, T., Chen, L., Wang, C., 2005. Antitumor effects of zerumbone from Zingiber zerumbet in P-388D1 cells in vitro and in vivo. Planta Med. 71, 219-224.
|
Commercial |
Zerumbone |
Activity against breast cancer cells |
Sung et al. (2008)Sung, B., Jhurani, S., Ahn, K.S., Mastuo, Y., Yi, T., Guha, S., Liu, M., Aggarwal, B.B., 2008. Zerumbone down-regulates chemokine receptor CXCR4 expression leading to inhibition of CXCL12-induced invasion of breast and pancreatic tumor cells. Cancer. Res. 68, 8938-8944.
|
Rhizome |
Ethyl acetate |
Nephroprotective effects |
Abdul Hamid et al. (2012)Abdul Hamid, Z., Budin, S.B., Jie, N.W., Hamid, A., Husain, K., Mohamed, J., 2012. Nephroprotective effects of Zingiber zerumbet Smith ethyl acetate extract against paracetamol-induced nephrotoxicity and oxidative stress in rats. Biomed. Biotechnol. 13, 176-185.
|
Rhizome |
Ethanol |
Analgesic and anti-pyretic activities |
Somchit et al. (2005)Somchit, M.N., Shukriyah, M.H.N., Bustamam, A.A., Zuraini, A., 2005. Anti-pyretic and analgesic activity of Zingiber zerumbet. Int. J. Pharm. 1, 277-280.
|
Rhizome |
Zerumbone |
Systemic antinociception |
Perimal et al. (2010)Perimal, E.K., Akhtar, M.N., Mohamad, A.S., Khalid, M.H., Ming, O.H., Khalid, S., Tatt, L.M., Kamaldin, M.N., Zakaria, Z.A., Israf, D.A., Lajis, N., Sulaiman, M.R., 2010. Zerumbone-induced antinociception: involvement of the l-arginine-nitric oxide-cGMP-PKC-K+ ATP channel pathways. Basic Clin. Pharmacol. 108, 155-162.
|
Rhizome |
Water |
Aqueous extract are not acute toxic in concentrations of the test |
Hashemi et al. (2008)Hashemi, S.R., Zulkifli, I., Bejo, M.H., Farida, A., Somchit, M.N., 2008. Acute toxicity study and phytochemical screening of selected herbal aqueous extract in broiler chickens. Int. J. Pharmacol. 4, 352-360.
|
Rhizome |
Zerumbone |
Gastroprotective effect |
Sidahmed et al. (2015)Sidahmed, H.M., Hashim, N.M., Abdulla, M.A., Ali, H.M., Mohan, S., Abdelwahab, S.I., Taha, M.M., Fai, L.M., Vadivelu, J., 2015. Antisecretory, gastroprotective, antioxidant and anti-helicobcter pylori activity of zerumbone from Zingiber zerumbet (L.) Smith. PLOS ONE, http://dx.doi.org/10.1371/journal.pone.0121060. http://dx.doi.org/10.1371/journal.pone.0...
|
Rhizome |
Zerumbone |
Alzheimer's disease treatment |
Bustamam et al. (2008)Bustamam, A., Ibrahim, S., Al-zubairi, A.S., Met, M., Syam, M.M., 2008. Zerumbone: a natural compound with anti-cholinesterase activity. Am. J. Pharm. Toxicol. 3, 209-211.
|
Commercial |
Zerumbone |
Inhibition of angiogenesis |
Park et al. (2015)Park, J., Park, G.M., Kim, J., 2015. Zerumbone, sesquiterpene photochemical from ginger, inhibits angiogenesis. Korean J. Physiol. Pharmacol. 19, 335-340.
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