Antinociceptive and antiinflammatory activities of the aqueous extract and isolated Cuphea carthagenensis (Jacq.) J. F. Macbr.

Antinociceptive and antiinflammatory activities of the aqueous extract and isolated Cuphea carthagenensis (Jacq.) J. F. Macbr.

Francis Rigolo Fernandes^I; André Luis dos Santos^I; Ana Maria Soares de Arruda^II; Luciana de Miranda C. Vasques-Pinto^I; Rosely Oliveira Godinho^I; Luce Maria Brandão Torres^I; Antonio José Lapa^I; Caden Souccar^{I, *}

^IDepartment of Pharmacology, Natural Products Section, Universidade Federal de São Paulo, Escola Paulista de Medicina, Rua Três de Maio 100, 04044-020, São Paulo, SP

^IIDepartment of Pharmacology, Universidade Federal do Paraná, Curitiba, PR, Brazil

ABSTRACT

The aqueous extract (AE) and isolated fraction (ppt-3) of Cuphea carthagenensis (Jacq.) J. F. Macbr (sete-sangrias) were tested using models of nociception and inflammation in mice. Oral administration (p.o.) of the AE (10 to 100 mg/kg) and fraction ppt-3 (0.1 to 10 mg/kg) reduced the acetic acid-induced writhing in mice by 40 to 50% and by 46 to 70% of control, respectively. At the same doses AE and ppt-3 did not affect the tail flick response. Fraction ppt-3 also reduced the carrageenininduced paw edema, but at a dose 1000 times higher than that inducing antinociception. The results indicated the presence in the plant of antinociceptive constituents devoid of antiinflammatory activity, with actions apparently mediated by non-opioid mechanisms.

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Acknowledgments

This work was supported by grants from Central de Medicamentos (CEME - MS) and Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). FRF was a recipient of a fellowship from CNPq (IC); ALS and LMCVP received a MS fellowship from CAPES.

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Publication Dates

• Publication in this collection
  05 Oct 2009
• Date of issue
  2002