Chemical constituents from ethanol extract of <i>Polyalthia rumphii</i> branches and their cytotoxicity evaluation

Wang, Tianshan; Wu, Xiaopeng; Liu, Yanping; Luo, Youping; Li, Xiang; Zhou, Yujie; Yang, AiPing; Yan, Zhengmeng; Ye, Ling; Chen, Siwei; Fu, Jinshuai; Jiao, Xianzhi

doi:10.1016/j.bjp.2018.03.004

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Revista Brasileira de Farmacognosia

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Short communications • Rev. bras. farmacogn. 28 (2) • Mar-Apr 2018 • https://doi.org/10.1016/j.bjp.2018.03.004 copy

Chemical constituents from ethanol extract of Polyalthia rumphii branches and their cytotoxicity evaluation

Authorship SCIMAGO INSTITUTIONS RANKINGS

ABSTRACT

Twelve known compounds, including eight alkaloids, three lignans and one gossypol derivative, were isolated from the branches of Polyalthia rumphii (Blume ex Hensch.) Merr., Annonaceae. The chemical structures were determined by spectroscopic methods and comparison with literature data. All the isolates were evaluated the cytotoxicity against three human cancer cell lines: Hela, MCF-7 and A549, the results showed that partial of isolates displayed weak cytotoxicities with the IC₅₀ values ranging from 25 to 40 µg/ml.

Keywords:
Alkaloids; Lignan; Gossypol derivative; Cytotoxic activity; Polyalthia rumphii

Isolates	Cancer cell lines/IC₅₀ (µg/ml)
	Hela	MCF-7	A549
2	32.3	>40^a a Inactive at IC50 > 40 µg/ml.	>40
4	35.5	36.9	38.0
6	32.3	32.9	39.3
7	29.7	36.7	>40
8	26.9	36.2	33.4
12	37.0	>40	>40
Doxorubicin	0.5	0.9	1.4

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[1] * Corresponding author. wtsmount@126.com