Annona glabra Linneau, Annonaceae, is a small tree that grows over the Brazilian territory particularly in its coast, and is known as "araticum-do-brejo" and "araticum-bravo". The aim of this study was to evaluate the effects of the extract of A. glabra and its purified kaurenoic acid on the locomotion of human granulocytes and their immunomodulatory potential. The results herein presented showed a dose-dependent inhibition of the granulocyte migration for the extract, suggesting an anti-inflammatory activity, in contrast with a striking stimulation observed for the kaurenoic acid. When focusing immunomodulation properties, no activity could be drawn. The effects presented in this work are reported for the first time and extend the list of biological activities already described for the A. glabra extract as well as for the kaurenoic acid.
Annona glabra; Annonaceae; kaurenoic acid; human leukocytes; chemotaxis; immunomodulation
