Pottel et al.2121 Pottel L, Lycke M, Boterberg T, Pottel H, Goethals L, Duprez F, et al. G-8 indicates overall and quality-adjusted survival in older head and neck cancer patients treated with curative radiochemotherapy. BMC Cancer. 2015;15:875. 2015 / Belgium |
≥65 years, head and neck neoplasms, submitted to radiotherapy / N = 100 |
Cohort / Determine if CGA is indicative of long-term health-related QoL and overall survival |
EQ-5D |
Vulnerable patients had lower long-term health-related QoL levels |
CGA was a predictor of QoL |
Baier et al.2222 Baier P, Ihorst G, Wolff-Vorbeck G, Hüll M, Hopt U, Deschler B. Independence and health related quality of life in 200 onco-geriatric surgical patients within 6 months of follow-up: Who is at risk to lose? Eur J Surg Oncol. 2016;42(12):1890-7. 2016 / Germany |
> 70 years old, any neoplasia, submitted to surgery with curative intention / N = 200 |
Cohort / Assess the prognostic impact of CGA on independence and QoL six months after surgery |
EORTC QLQ-C30 |
QoL correlated with Karnofsky index, emotional functioning and activities of daily living |
CGA was a predictor of QoL |
Hempenius et al.2323 Hempenius L, Slaets JPJ, van Asselt D, de Bock TH, Wiggers T, van Leeuwen BL. Long Term Outcomes of a Geriatric Liaison Intervention in Frail Elderly Cancer Patients. PLoS ONE. 2016;11(2):e0143364. 2016 / Netherlands |
≥65 years old, any neoplasm, submitted to elective surgery / N = 260 |
Clinical trial / Assess the long-term outcomes of a geriatric intervention for the prevention of delirium in frail older adults |
Short Form-36 score |
There were no differences between the intervention group and the usual treatment group for any of the outcomes three months after discharge. |
Geriatric intervention based on CGA findings did not improve QoL |
Pergolotti et al.2424 Pergolotti M, Deal AM, Williams GR, Bryant AL, Bensen JT, Muss HB, et al. Activities, function, and health-related quality of life (HRQOL) of older adults with cancer. J Geriatr Oncol. 2017;8(4):249-54. 2017 / USA |
≥65 years, any neoplasm / N = 768 |
Cohort / Describe functional status and QoL and identify associations with demographic variables, comorbidities and functional status |
FACT-G |
The presence of comorbidities and reduced levels of activity / functional capacity were associated with worse levels of QoL |
CGA was a predictor of QoL |
Ribi et al.2525 Ribi K, Rondeau S, Hitz F, Mey U, Enoiu M, Pabst T, et al. Cancer-specific geriatric assessment and quality of life: important factors in caring for older patients with aggressive B-cell lymphoma. Support Care Cancer. 2017;25(9):2833-42. 2017 / Switzerland |
B-cell lymphoma not eligible for intensive treatment / N = 57 |
Clinical trial / Characterize the patients by objective response and survival based on CGA and QoL and describe QoL changes after treatment |
Domains assessed: physical well-being, mood, coping, functional status, tiredness, nausea/vomiting and taste disorders |
CGA impairment is an important factor in clinical outcomes and interventions in specific geriatric domains translate into improved QoL |
CGA was a predictor of QoL |
Schmidt et al.2626 Schmidt H, Boese S, Lampe K, Jordan K, Fiedler E, Müller-Werdan U, et al. Trans sectoral care of geriatric cancer patients based on comprehensive geriatric assessment and patient-reported quality of life - Results of a multicenter study to develop and pilot test a patient-centered interdisciplinary care concept for geriatric oncology patients (PIVOG). J Geriatr Onco.l 2017;8(4):262-70. 2017 / Germany |
≥70 years, any neoplasm / N = 100 |
Clinical trial / Assess the impact of an CGA-based intervention program on QL preservation |
EORTC QLQ-C30 |
Geriatric intervention demonstrated benefit in preserving QoL |
Geriatric intervention based on CGA findings helps to preserve QoL |
VanderWalde et al.2727 VanderWalde NA, Deal AM, Comitz E, Stravers L, Muss H, Reeve BB, et al. Geriatric assessment as a predictor of tolerance, quality of life, and outcomes in older patients with head and Neck Cancers and Lung Cancers receiving radiation therapy. Int J Radiat Oncol Biol Phys. 2017;98(4):850-7. 2017 / USA |
≥65 years, head and neck or lung cancer undergoing radiotherapy / N = 50 |
Cohort / Assess the association between functional status based on CGA and treatment tolerance results |
EORTC QLQ-C30 |
There was no association between dysfunction and tolerance, but altered CGA was associated with continuous decline and lack of recovery of QoL |
CGA was a predictor of QoL |
Goineau et al.2828 Goineau A, Campion L, d’Aillières B, Vié B, Ghesquière A, Béra G, et al. Comprehensive Geriatric Assessment and quality of life after localized prostate cancer radiotherapy in elderly patients. PLoS ONE. 2018;13(4):e0194173. 2018 / France |
≥75 years old, prostate cancer, submitted to radiotherapy / N = 100 |
Cohort / Assess the effect of radiotherapy on QoL and identify predictors of QoL reduction |
EORTC QLQ-C30 |
Radiotherapy for prostate cancer was well tolerated among this population and no predictive factor was found to determine which patients would have impaired QoL after radiotherapy |
CGA was a predictor of QoL |
Phaibulvatanapong et al.2929 Phaibulvatanapong E, Srinonprasert V, Ithimakin S. Risk factors for chemotherapy-related toxicity and adverse events in elderly thai cancer patients: a prospective study. Oncology. 2018;94(3):149-60. 2018 / Thailand |
≥70 years old, any neoplasm under systemic treatment / N = 151 |
Cohort / Assess factors that predispose individual to chemotherapy-related toxicity and QoL |
FACT-G |
Performance status and the presence of comorbidities were associated with a higher incidence of serious adverse events and worse QoL |
CGA was a predictor of QoL |
Puts et al.3030 Puts MTE, Sattar S, Kulik M, MacDonald ME, McWatters K, Lee K, et al. A randomized phase II trial of geriatric assessment and management for older cancer patients. Support Care Cancer. 2018;26(1):109-17. 2018 / Canada |
≥70 years old, gastrointestinal, genitourinary or EC II-IV breast cancer, before start of chemotherapy / N = 61 |
Clinical trial / Explore the feasibility and impact of CGA and an integrated care plan on QoL and cancer treatment decisions |
EORTC QLQ-C30 |
Patients who received CGA-based support had better QoL levels |
Geriatric intervention based on CGA findings helps to preserve QoL |
Jeppesen et al.3131 Jeppesen SS, Matzen LE, Brink C, Bliucukiene R, Kasch S, Schytte T, et al. Impact of comprehensive geriatric assessment on quality of life, overall survival, and unplanned admission in patients with non-small cell lung cancer treated with stereotactic body radiotherapy. J Geriatr Oncol. 2018;9(6):575-82. 2018 / Denmark |
Lung neoplasm T1-2N0M0, not candidates for surgical treatment / N = 51 |
Clinical trial / Investigate whether CGA as part of an interventionist tool can impact QoL and overall survival |
EQ-5D |
CGA did not impact QoL and overall survival in this population |
Geriatric intervention based on CGA findings did not improve QoL |
Kirkhus et al.1414 Kirkhus L, Harneshaug M, Benth LS, Gronberg BH, Rostoft S, Bergh S, et al. Modifiable factors affecting older patients’ quality of life and physical function during cancer treatment. J Geriatr Oncol. 2019;10(6):904-12. 2019 / Norway |
≥70 years old, any neoplasm under systemic treatment / N = 288 |
Cohort / Identify potentially modifiable factors that affect physical function and QoL during cancer treatment |
EORTC QLQ-C30 |
Depressive symptoms, reduced mobility and physical symptoms increased the risk of decreases in QoL scores |
CGA was a predictor of QoL |
Kirkhus et al. 3232 Kirkhus L, Benth JS, Gronberg BH, Hjermstad MJ, Rostoft S, Harneshaug M, et al. Frailty identified by geriatric assessment is associated with poor functioning, high symptom burden and increased risk of physical decline in older cancer patients: Prospective observational study. Palliat Med. 2019;33(3):312-22. 2019 / Norway |
≥70 years, any neoplasia / N = 288 |
Cohort / Investigate whether the frailty identified by an CGA was associated with an increased risk of QoL deterioration during cancer treatment and follow-up |
EORTC QLQ-C30 |
Frail patients had significantly worse physical functioning and QoL during follow-up |
CGA was a predictor of QoL |
Mohile et al.33 Mohile SG, Dale W, Somerfield MR, Schonberg MA, Boyd CM, Burhenn PS, et al. Practical assessment and management of vulnerabilities in older patients receiving chemotherapy: ASCO Guideline for Geriatric Oncology. J Clin Oncol. 2018;36(22):2326-47. 2019 / USA |
≥70 years old, any neoplasm, impaired CGA domain / N = 541 |
Clinical trial / Determine whether providing CGA-guided recommendations to oncologists can improve communication about aging-related concerns |
FACT-G |
Geriatric assessment improves patient-centered communication about aging-related concerns, but has not changed QoL |
Geriatric intervention based on CGA findings did not improve QoL |
Quinten et al.3333 Quinten C, Kenis C, Decoster L, Debruyne PR, de Groof I, Focan C, et al. Determining clinically important differences in health-related quality of life in older patients with cancer undergoing chemotherapy or surgery. Qual Life Res. 2019;28(3):663-76. 2019 / Belgium |
≥70 years old, any neoplasia, submitted to chemotherapy or surgery, G8 ≤ 14 / N = 1424 |
Cohort / Determine the minimum estimates of clinically important differences in QoL and evaluate prognostic characteristics for these changes in QoL |
EORTC QLQ-C30 |
Minimum estimates of clinically important differences in QoL vary by instrument and treatment, but can be used to assess significant changes in QoL |
CGA was a predictor of QoL |
Williams et al.55 Williams GR, Deal AM, Sanoff HK, Nyrop KA, Guerard EJ, Pergolotti M, et al. Frailty and health-related quality of life in older women with breast cancer. Support Care Cancer. 2019;27(7):2693-98. 2019 / USA |
≥65 years, breast cancer / N = 190 |
Cohort / Assess the association between frailty and QoL |
PROMIS® |
Frailty in older women with breast cancer was associated with worse QoL results |
CGA was a predictor of QoL |
de Boer et al.66 de Boer AZ, Derks MGM, de Glas NA, Bastiaannet E, Liefers GJ, Stiggelbout AM. Metastatic breast cancer in older patients: A longitudinal assessment of geriatric outcomes. J Geriatr Oncol. 2020;11(6):969-75. 2020 / Netherlands |
≥70 years, metastatic breast cancer / N = 100 |
Cohort / Assess the prevalence of psychosocial diseases and longitudinal changes in functional status, psychosocial functioning and QoL |
EORTC QLQ-C30 |
High prevalence of psychiatric disorders in this population; its identification, through CGA can improve QoL |
Geriatric intervention based on CGA findings helps to preserve QoL |
Mian et al.1616 Mian H, Pond GR, Tuchman SA, Fiala MA, Wildes TM. Geriatric assessment and quality of life changes in older adults with newly diagnosed multiple myeloma undergoing treatment. J Geriatr Oncol. 2020;11(8):1279-84. 2020 / Canada |
≥65 years, recent diagnosis of multiple myeloma / N = 40 |
Cohort / Understand the changes in the geriatric domains and QoL parameters during cancer treatment |
FACT-G |
In this population, QoL remained stable during the 6-month follow-up period; the Timed Up and Go test can provide a dynamic indicator of functional status and QoL |
CGA was a predictor of QoL |
Nipp et al.1313 Nipp RD, Temel B, Fuh CX, Kay P, Landay S, Lage D, et al. Pilot randomized trial of a transdisciplinary geriatric and palliative care intervention for older adults with cancer. J Natl Compr Canc Netw. 2020;18(5):591-8. 2020 / USA |
≥65 years, incurable gastrointestinal or lung cancer / N = 62 |
Clinical trial / Determining the feasibility of a transdisciplinary intervention based on an CGA |
FACT-G |
Transdisciplinary intervention aimed at the care needs of older adults showed encouraging estimates to improve QoL |
Geriatric intervention based on CGA findings helps to preserve QoL |
Nipp et al. 88 Nipp RD, Thompson LL, Temel B, Fuh CX, Server C, Kay PS, et al. Screening tool identifies older adults with cancer at risk for poor outcomes. J Natl Compr Canc Netw. 2020;18(3):305-13. 2020 / USA |
≥70 years, recent diagnosis of incurable gastrointestinal neoplasm N = 132 |
Cohort / Determine whether categorizing patients as vulnerable by an CGA could identify those with the worst health outcomes |
EORTC QLQ-C30 |
Patients identified as vulnerable by CGA have worse QoL and overall survival |
CGA was a predictor of QoL |
Quinten et al. 1515 Quinten C, Kenis C, Hamaker M, Coolbrandt A, Brouwers B, Dal Lago L, el al. The added value of geriatric assessment in evaluating a patient’s Health-Related Quality-of-Life: a study in ≥70-year-old early-stage invasive breast cancer patients. Eur J Cancer Care (Engl). 2020;e13278. 2020 / Belgium |
≥70 years old, early stage breast cancer N = 109 |
Case-control / Assess the relationship between CGA and QoL |
EORTC QLQ-C30 |
Functional measures of CGA are strongly correlated with the patient's self-reported functioning; the initial altered CGA has a modest probability of predicting deterioration of QoL |
CGA was a predictor of QoL |