Outcome |
Interventions |
Author, year |
Increased muscle strength |
Ex. + NuOri + ProTh |
Chan et al., 20121919 Chan DC, Tsou HH, Yang RS, Chen CY, Hsiung CA, Kuo KN. A pilot randomized controlled trial to improve geriatric frailty. BMC Geriatr. 2012;12:1-12
|
Ex. + NuOri + ProTh + HoCa Ex. + NuOri + ProTh |
Chan et al., 20172020 Chan DD, Tsou HH, Chang CB, Yang RS, Tasauo JY, et al. Integrated care for geriatric frailty and sarcopenia: a randomized control trial. J Cachexia Sarcopenia Muscle. 2017;8(1):78-88.
|
Ex. CogTra Ex. +CogTra + VMNu |
Ng et al., 20152222 Ng TP, Nyunt MSZ, Feng L, Feng M, et al. Multi-domains lifestyle interventions reduces depressive symptoms among frail and pre-frail older persons: randomized controlled trial. J Nutr Health Aging. 2017;21(8):918-26.
|
MuProg. |
Fairhall et al., 20142525 Fairhall N, Sherrington C, Lord SR, Kurrle SE, Langron C, Lockwood K, et al. Effect of a multifactorial, interdisciplinary intervention on risk factors for falls and fall rate in frail older people: a randomised controlled trial. Age Ageing. 2014;43(5):616-22.
|
Probiotic nutritional supplementation |
Buigues et al., 20161616 Buigues C, Fernandez-Garrido J, Pruimboom L, Hoogland A, Navarro-Martínez R, MartÍnez-Martínez M, et al. Effect of a prebiotic formulation on frailty syndrome: a randomized, double-Blind clinical trial. Int J Mol Sci. 2016;17(6):1-12.
|
Increased gaitspeed |
Ex. + NuOri + ProTh + HoCa Ex. + NuOri + ProTh + Su |
Chan et al., 20172020 Chan DD, Tsou HH, Chang CB, Yang RS, Tasauo JY, et al. Integrated care for geriatric frailty and sarcopenia: a randomized control trial. J Cachexia Sarcopenia Muscle. 2017;8(1):78-88.
|
Ex. VMNu CogTra Ex. +CogTra + VMNu |
Ng et al., 20152222 Ng TP, Nyunt MSZ, Feng L, Feng M, et al. Multi-domains lifestyle interventions reduces depressive symptoms among frail and pre-frail older persons: randomized controlled trial. J Nutr Health Aging. 2017;21(8):918-26.
Ng et al., 20172323 Ng TP, Feng L, Nyunt MS, et al. Nutritional, physical, cognitive, and combination interventions and frailty reversal among older adults: a randomized controlled trial. Am J Med. 2015;128(11):1225-36.
|
MuProg. |
Fairhall et al., 20142525 Fairhall N, Sherrington C, Lord SR, Kurrle SE, Langron C, Lockwood K, et al. Effect of a multifactorial, interdisciplinary intervention on risk factors for falls and fall rate in frail older people: a randomised controlled trial. Age Ageing. 2014;43(5):616-22.
Cameron et al., 20151818 Cameron ID, Fairhall N, Gill L, Lockwood C, Aggar C, Monaghan N, et al. Developing interventions for frailty. Adv Geriatr. 2015;2015:1-7.
Cameron et al., 20131717 Cameron ID, Fairhall N, Langron C, Lockwood K, Monaghan N, et al. A multifactorial interdisciplinary intervention reduces frailty in older people: randomized trial. BMC Geriatr. 2013;11:1-10.
|
Probiotic nutritional supplementation |
Buigues et al., 20161616 Buigues C, Fernandez-Garrido J, Pruimboom L, Hoogland A, Navarro-Martínez R, MartÍnez-Martínez M, et al. Effect of a prebiotic formulation on frailty syndrome: a randomized, double-Blind clinical trial. Int J Mol Sci. 2016;17(6):1-12.
|
Ex. MfgmNu Ex. + MfgmNu |
Kim et al., 20152828 Kim H, Suzuki T, Kim M, Kojima N, Ota N, Shimotoyodone A, et al. Effects of exercise and milk fat globule membrane (MFGM) supplementation on body composition, physical function, and hematological parameters in community-dwelling frail Japanese women: a randomized double blind, placebo-controlled, follow-up trial. PLoS ONE. 2015;10(2):1-20.
|
Increased body weight |
Ex. + NuOri + ProTh |
Chan et al., 20121919 Chan DC, Tsou HH, Yang RS, Chen CY, Hsiung CA, Kuo KN. A pilot randomized controlled trial to improve geriatric frailty. BMC Geriatr. 2012;12:1-12
|
Ex. VMNu Cognitive training Ex. +CogTra + VMNu |
Ng et al., 20152222 Ng TP, Nyunt MSZ, Feng L, Feng M, et al. Multi-domains lifestyle interventions reduces depressive symptoms among frail and pre-frail older persons: randomized controlled trial. J Nutr Health Aging. 2017;21(8):918-26.
|
Ex. + MfgmNu |
Kim et al., 20152828 Kim H, Suzuki T, Kim M, Kojima N, Ota N, Shimotoyodone A, et al. Effects of exercise and milk fat globule membrane (MFGM) supplementation on body composition, physical function, and hematological parameters in community-dwelling frail Japanese women: a randomized double blind, placebo-controlled, follow-up trial. PLoS ONE. 2015;10(2):1-20.
|
Ex. + NuOri + VMNu |
Tarazona-Santabalbina et al., 20162121 Tarazona-Santabalbina F, Gomez-Cabrera M, Perez-Ros P, Martínez-Arnau F, Tsaparas K, et al. A multicomponent exercise intervention that reverses frailty and improves cognition, emotion, and social networking in the community-dwelling frail elderly: a randomized clinical trial. J Am Med Dir Assoc. 2016;17(5):426-33.
|
OriBGE |
Li et al. 20102424 Li CM, Chen CY, Li CY, Wang WD, Wu SC. The effectiveness of a comprehensive geriatric assessment intervention program for frailty in community-dwelling older people: a randomized, controlled trial. Arch Gerontol Geriatr. 2010;50(suppl 1):39-42.
|
Improvement in self-reported exhaustion |
Probiotic nutritional supplementation |
Buigues et al., 20161616 Buigues C, Fernandez-Garrido J, Pruimboom L, Hoogland A, Navarro-Martínez R, MartÍnez-Martínez M, et al. Effect of a prebiotic formulation on frailty syndrome: a randomized, double-Blind clinical trial. Int J Mol Sci. 2016;17(6):1-12.
|
Ex. MfgmNu Ex. + MfgmNu |
Kim et al., 20152828 Kim H, Suzuki T, Kim M, Kojima N, Ota N, Shimotoyodone A, et al. Effects of exercise and milk fat globule membrane (MFGM) supplementation on body composition, physical function, and hematological parameters in community-dwelling frail Japanese women: a randomized double blind, placebo-controlled, follow-up trial. PLoS ONE. 2015;10(2):1-20.
|
Ex. + NuOri + ProTh + HoCa Ex. + NuOri + ProTh |
Chan et al., 20172020 Chan DD, Tsou HH, Chang CB, Yang RS, Tasauo JY, et al. Integrated care for geriatric frailty and sarcopenia: a randomized control trial. J Cachexia Sarcopenia Muscle. 2017;8(1):78-88.
|
Increased physical activity |
Ex. + NuOri + ProTh + HoCa Ex. + NuOri + ProTh + Su |
Chan et al., 20172020 Chan DD, Tsou HH, Chang CB, Yang RS, Tasauo JY, et al. Integrated care for geriatric frailty and sarcopenia: a randomized control trial. J Cachexia Sarcopenia Muscle. 2017;8(1):78-88.
|
VMNu |
Ng et al., 20152222 Ng TP, Nyunt MSZ, Feng L, Feng M, et al. Multi-domains lifestyle interventions reduces depressive symptoms among frail and pre-frail older persons: randomized controlled trial. J Nutr Health Aging. 2017;21(8):918-26.
|
Ex. + MfgmNu |
Kim et al., 20152828 Kim H, Suzuki T, Kim M, Kojima N, Ota N, Shimotoyodone A, et al. Effects of exercise and milk fat globule membrane (MFGM) supplementation on body composition, physical function, and hematological parameters in community-dwelling frail Japanese women: a randomized double blind, placebo-controlled, follow-up trial. PLoS ONE. 2015;10(2):1-20.
|
Ex. + NuOri + VMNu |
Tarazona-Santabalbina et al., 20162121 Tarazona-Santabalbina F, Gomez-Cabrera M, Perez-Ros P, Martínez-Arnau F, Tsaparas K, et al. A multicomponent exercise intervention that reverses frailty and improves cognition, emotion, and social networking in the community-dwelling frail elderly: a randomized clinical trial. J Am Med Dir Assoc. 2016;17(5):426-33.
|
Ex. |
Cesari et al., 20152727 Cesari M, Vellas B, Hsu FC, Newman AB, Doss H, King AC, et al. A physical activity intervention to treat the frailty syndrome in older persons: results from the LIFE-P study. J Gerontol Ser A Biol Sci Med Sci. 2015;70(2):216-22.
|
ADL and IADL dependence |
Ex. + NuOri + VMNu |
Tarazona-Santabalbina et al., 20162121 Tarazona-Santabalbina F, Gomez-Cabrera M, Perez-Ros P, Martínez-Arnau F, Tsaparas K, et al. A multicomponent exercise intervention that reverses frailty and improves cognition, emotion, and social networking in the community-dwelling frail elderly: a randomized clinical trial. J Am Med Dir Assoc. 2016;17(5):426-33.
|
Health care |
Ex. + NuOri + VMNu |
Tarazona-Santabalbina et al., 20162121 Tarazona-Santabalbina F, Gomez-Cabrera M, Perez-Ros P, Martínez-Arnau F, Tsaparas K, et al. A multicomponent exercise intervention that reverses frailty and improves cognition, emotion, and social networking in the community-dwelling frail elderly: a randomized clinical trial. J Am Med Dir Assoc. 2016;17(5):426-33.
|
Osteopenia |
Ex. + NuOri + ProTh |
Chan et al., 20121919 Chan DC, Tsou HH, Yang RS, Chen CY, Hsiung CA, Kuo KN. A pilot randomized controlled trial to improve geriatric frailty. BMC Geriatr. 2012;12:1-12
|
Vitamin D |
Ex. + NuOri + ProTh |
Chan et al., 20121919 Chan DC, Tsou HH, Yang RS, Chen CY, Hsiung CA, Kuo KN. A pilot randomized controlled trial to improve geriatric frailty. BMC Geriatr. 2012;12:1-12
|
25-Hydroxyvitamin D Level |
Ex. + NuOri + ProTh |
Chan et al., 20121919 Chan DC, Tsou HH, Yang RS, Chen CY, Hsiung CA, Kuo KN. A pilot randomized controlled trial to improve geriatric frailty. BMC Geriatr. 2012;12:1-12
|
Falls |
MuProg |
Fairhall et al., 20142525 Fairhall N, Sherrington C, Lord SR, Kurrle SE, Langron C, Lockwood K, et al. Effect of a multifactorial, interdisciplinary intervention on risk factors for falls and fall rate in frail older people: a randomised controlled trial. Age Ageing. 2014;43(5):616-22.
|
Ex. + NuOri + VMNu |
Tarazona-Santabalbina et al., 20162121 Tarazona-Santabalbina F, Gomez-Cabrera M, Perez-Ros P, Martínez-Arnau F, Tsaparas K, et al. A multicomponent exercise intervention that reverses frailty and improves cognition, emotion, and social networking in the community-dwelling frail elderly: a randomized clinical trial. J Am Med Dir Assoc. 2016;17(5):426-33.
|
Exercise |
Faber et al., 20061515 Faber MJ, Bosscher RJ, Paw MJCA, van Wieringen PC. Effects of exercise programs on falls and mobility in frail and pre-frail older adults: a multicenter randomized controlled trial. Arch Physi Med Rehabil. 2006;87(7):885-96.
|
Balance |
MuProg. |
Fairhall et al., 20142525 Fairhall N, Sherrington C, Lord SR, Kurrle SE, Langron C, Lockwood K, et al. Effect of a multifactorial, interdisciplinary intervention on risk factors for falls and fall rate in frail older people: a randomised controlled trial. Age Ageing. 2014;43(5):616-22.
|
Ex. |
Faber et al., 20061515 Faber MJ, Bosscher RJ, Paw MJCA, van Wieringen PC. Effects of exercise programs on falls and mobility in frail and pre-frail older adults: a multicenter randomized controlled trial. Arch Physi Med Rehabil. 2006;87(7):885-96.
|
Physical performance |
MuProg. |
Fairhall et al., 20142525 Fairhall N, Sherrington C, Lord SR, Kurrle SE, Langron C, Lockwood K, et al. Effect of a multifactorial, interdisciplinary intervention on risk factors for falls and fall rate in frail older people: a randomised controlled trial. Age Ageing. 2014;43(5):616-22.
Cameron et al., 20131717 Cameron ID, Fairhall N, Langron C, Lockwood K, Monaghan N, et al. A multifactorial interdisciplinary intervention reduces frailty in older people: randomized trial. BMC Geriatr. 2013;11:1-10.
|
Ex. + NuOri + VMNu |
Tarazona-Santabalbina et al., 20162121 Tarazona-Santabalbina F, Gomez-Cabrera M, Perez-Ros P, Martínez-Arnau F, Tsaparas K, et al. A multicomponent exercise intervention that reverses frailty and improves cognition, emotion, and social networking in the community-dwelling frail elderly: a randomized clinical trial. J Am Med Dir Assoc. 2016;17(5):426-33.
|
Ex. |
Faber et al., 20061515 Faber MJ, Bosscher RJ, Paw MJCA, van Wieringen PC. Effects of exercise programs on falls and mobility in frail and pre-frail older adults: a multicenter randomized controlled trial. Arch Physi Med Rehabil. 2006;87(7):885-96.
|
Functional state |
Probiotic nutritional supplementation |
Buigues et al., 20161616 Buigues C, Fernandez-Garrido J, Pruimboom L, Hoogland A, Navarro-Martínez R, MartÍnez-Martínez M, et al. Effect of a prebiotic formulation on frailty syndrome: a randomized, double-Blind clinical trial. Int J Mol Sci. 2016;17(6):1-12.
|
Ex. |
Faber et al., 20061515 Faber MJ, Bosscher RJ, Paw MJCA, van Wieringen PC. Effects of exercise programs on falls and mobility in frail and pre-frail older adults: a multicenter randomized controlled trial. Arch Physi Med Rehabil. 2006;87(7):885-96.
|
Sleep quality |
Probiotic nutritional supplementation |
Buigues et al., 20161616 Buigues C, Fernandez-Garrido J, Pruimboom L, Hoogland A, Navarro-Martínez R, MartÍnez-Martínez M, et al. Effect of a prebiotic formulation on frailty syndrome: a randomized, double-Blind clinical trial. Int J Mol Sci. 2016;17(6):1-12.
|
Mental state |
Probiotic nutritional supplementation |
Buigues et al., 20161616 Buigues C, Fernandez-Garrido J, Pruimboom L, Hoogland A, Navarro-Martínez R, MartÍnez-Martínez M, et al. Effect of a prebiotic formulation on frailty syndrome: a randomized, double-Blind clinical trial. Int J Mol Sci. 2016;17(6):1-12.
|
Ex. + NuOri + VMNu |
Tarazona-Santabalbina et al., 20162121 Tarazona-Santabalbina F, Gomez-Cabrera M, Perez-Ros P, Martínez-Arnau F, Tsaparas K, et al. A multicomponent exercise intervention that reverses frailty and improves cognition, emotion, and social networking in the community-dwelling frail elderly: a randomized clinical trial. J Am Med Dir Assoc. 2016;17(5):426-33.
|
Social support |
Ex. + NuOri + VMNu |
Tarazona-Santabalbina et al., 20162121 Tarazona-Santabalbina F, Gomez-Cabrera M, Perez-Ros P, Martínez-Arnau F, Tsaparas K, et al. A multicomponent exercise intervention that reverses frailty and improves cognition, emotion, and social networking in the community-dwelling frail elderly: a randomized clinical trial. J Am Med Dir Assoc. 2016;17(5):426-33.
|
Depression |
Ex. + NuOri + VMNu |
Tarazona-Santabalbina et al., 20162121 Tarazona-Santabalbina F, Gomez-Cabrera M, Perez-Ros P, Martínez-Arnau F, Tsaparas K, et al. A multicomponent exercise intervention that reverses frailty and improves cognition, emotion, and social networking in the community-dwelling frail elderly: a randomized clinical trial. J Am Med Dir Assoc. 2016;17(5):426-33.
|
Ex. VMNu Ex. +CogTra + VMNu |
Ng et al., 20172323 Ng TP, Feng L, Nyunt MS, et al. Nutritional, physical, cognitive, and combination interventions and frailty reversal among older adults: a randomized controlled trial. Am J Med. 2015;128(11):1225-36.
|
Quality of life |
Ex. + NuOri + VMNu |
Tarazona-Santabalbina et al., 20162121 Tarazona-Santabalbina F, Gomez-Cabrera M, Perez-Ros P, Martínez-Arnau F, Tsaparas K, et al. A multicomponent exercise intervention that reverses frailty and improves cognition, emotion, and social networking in the community-dwelling frail elderly: a randomized clinical trial. J Am Med Dir Assoc. 2016;17(5):426-33.
|
Calcium level |
Ex. + NuOri + VMNu |
Tarazona-Santabalbina et al., 20162121 Tarazona-Santabalbina F, Gomez-Cabrera M, Perez-Ros P, Martínez-Arnau F, Tsaparas K, et al. A multicomponent exercise intervention that reverses frailty and improves cognition, emotion, and social networking in the community-dwelling frail elderly: a randomized clinical trial. J Am Med Dir Assoc. 2016;17(5):426-33.
|
Blood clotting |
Ex. + NuOri + VMNu |
Tarazona-Santabalbina et al., 20162121 Tarazona-Santabalbina F, Gomez-Cabrera M, Perez-Ros P, Martínez-Arnau F, Tsaparas K, et al. A multicomponent exercise intervention that reverses frailty and improves cognition, emotion, and social networking in the community-dwelling frail elderly: a randomized clinical trial. J Am Med Dir Assoc. 2016;17(5):426-33.
|
Physical rehabilitation |
OriBGE |
Li et al. 20102424 Li CM, Chen CY, Li CY, Wang WD, Wu SC. The effectiveness of a comprehensive geriatric assessment intervention program for frailty in community-dwelling older people: a randomized, controlled trial. Arch Gerontol Geriatr. 2010;50(suppl 1):39-42.
|
Geriatric evaluation |
OriBGE |
Li et al. 20102424 Li CM, Chen CY, Li CY, Wang WD, Wu SC. The effectiveness of a comprehensive geriatric assessment intervention program for frailty in community-dwelling older people: a randomized, controlled trial. Arch Gerontol Geriatr. 2010;50(suppl 1):39-42.
|
Referrals to specialists |
OriBGE |
Li et al. 20102424 Li CM, Chen CY, Li CY, Wang WD, Wu SC. The effectiveness of a comprehensive geriatric assessment intervention program for frailty in community-dwelling older people: a randomized, controlled trial. Arch Gerontol Geriatr. 2010;50(suppl 1):39-42.
|
Polypharmacy |
OriBGE |
Li et al. 20102424 Li CM, Chen CY, Li CY, Wang WD, Wu SC. The effectiveness of a comprehensive geriatric assessment intervention program for frailty in community-dwelling older people: a randomized, controlled trial. Arch Gerontol Geriatr. 2010;50(suppl 1):39-42.
|
Mobility |
Ex. |
Faber et al., 20061515 Faber MJ, Bosscher RJ, Paw MJCA, van Wieringen PC. Effects of exercise programs on falls and mobility in frail and pre-frail older adults: a multicenter randomized controlled trial. Arch Physi Med Rehabil. 2006;87(7):885-96.
|