Brady et al. (2014)1818 Brady PC, Kaser DJ, Ginsburg ES, Ashby RK, Missmer SA, Correia KF, et al. Serum progesterone concentration on day of embryo transfer in donor oocyte cycles. J Assist Reprod Genet. 2014;31 (05):569-575. Doi: 10.1007/s10815-014-0199-y https://doi.org/10.1007/s10815-014-0199-...
J Assist Reprod Genet |
USA |
Retrospective |
229 |
donors |
1 to 3 embryos in D3 |
IM 50–100 mg |
> 20 ng/mL (64 nmol/l) |
4th day of administration = FET day |
65 VS 51% |
Kofinas et al. (2015)1616 Kofinas JD, Blakemore J, McCulloh DH, Grifo J. Serum progesterone levels greater than 20 ng/dl on day of embryo transfer are associatedwith lower live birth and higher pregnancy loss rates. J Assist Reprod Genet. 2015;32(09):1395-1399. Doi: 10.1007/s10815-015-0546-7 https://doi.org/10.1007/s10815-015-0546-...
J Assis Repro Gen |
USA |
Retrospective |
213 |
autologous |
1 euploid blastocysts |
Progesterone IM 50–75 mg |
< 20 ng/mL |
2nd and e 6th days of administration |
49 VS 65% |
Yovich et al. (2015)1919 Yovich JL, Conceicao JL, Stanger JD, Hinchliffe PM, Keane KN.Midluteal serum progesterone concentrations govern implantation rates for cryopreserved embryo transfers conducted under hormone replacement. Reprod Biomed Online. 2015;31(02): 180-191. Doi: 10.1016/j.rbmo.2015.05.005 https://doi.org/10.1016/j.rbmo.2015.05.0...
RBM Online |
Australia |
Retrospective |
529 |
autologous and donors |
1 vitrified blastocyst |
vaginal 400mg 3id ** |
50–100 nmol/L |
8th/9th day of administration |
50% VS 41%/36%*** |
Labarta et al. (2017)1515 Labarta E, Mariani G, Holtmann N, Celada P, Remohí J, Bosch E. Low serum progesterone on the day of embryo transfer is associated with a diminished ongoing pregnancy rate in oocyte donation cycles after artificial endometrial preparation: a prospective study. Hum Reprod. 2017;32(12):2437-2442. Doi: 10.1093/humrep/dex316 https://doi.org/10.1093/humrep/dex316...
Human Reprod |
Spain |
Prospective |
211 |
donors |
vitrified blastocysts |
vaginal 400 mg 2id |
> 11 ng/mL (> 35 nmol/L) |
6th day of administration = FET day |
33 VS 53% |
Basnayake et al. (2018)2020 Basnayake SK, VolovskyM, Rombauts L, Osianlis T, Vollenhoven B, Healey M. Progesterone concentrations and dosage with frozen embryo transfers -What's best? Aust N Z J Obstet Gynaecol. 2018; 58(05):533-538. Doi: 10.1111/ajo.12757 https://doi.org/10.1111/ajo.12757...
Aust N Z J Obstet Gynaecol |
Australia |
Retrospective |
1580 |
autologous and donors |
vitrified clivage and blastocysts □ |
vaginal in different doses |
> 50 nmol/L (15,7 ng/mL) |
16th day of administration |
26 VS 11% |
Alsbjerg et al. (2018)2121 Alsbjerg B, Thomsen L, Elbaek HO, Laursen R, Povlsen BB, Haahr T, et al. Progesterone levels on pregnancy test day after hormone replacement therapy-cryopreserved embryo transfer cycles and related reproductive outcomes. Reprod Biomed Online. 2018;37 (05):641-647. Doi: 10.1016/j.rbmo.2018.08.022 https://doi.org/10.1016/j.rbmo.2018.08.0...
RBM Online |
Denmark |
Retrospective |
244 |
autologous |
1 or 2 vitrified blastocysts |
vaginal 90 mg 3id |
> 35 nmol/L |
9th–11th day of administration = β-HCG day |
31% vs 51% |
Gaggiotti-Marre et al. (2018)1414 Gaggiotti-Marre S, Martinez F, Coll L, Garcia S, Álvarez M, Parriego M, et al. Low serum progesterone the day prior to frozen embryo transfer of euploid embryos is associated with significant reduction in live birth rates. Gynecol Endocrinol. 2019;35(05): 439-442. Doi: 10.1080/09513590.2018.1534952 https://doi.org/10.1080/09513590.2018.15...
Gynecological Endocr |
Spain |
Retrospective |
244 |
autologous |
euploid vitrified blastocysts |
vaginal 200 mg 3id |
10.64 ng/mL |
4th day of admnistration |
59.6 VS 41% |
Cédrin-Durnerin et al. (2018)2222 Cédrin-Durnerin I, Isnard T, Mahdjoub S, Sonigo C, Seroka A, Comtet M, et al. Serum progesterone concentration and live birth rate in frozen-thawed embryo transfers with hormonally prepared endometrium. Reprod Biomed Online. 2019;38(03): 472-480. Doi: 10.1016/j.rbmo.2018.11.026 https://doi.org/10.1016/j.rbmo.2018.11.0...
RBM Online |
France |
Retrospective |
227 |
?? |
vitrified clivage and blastocysts |
vaginal 200 mg 3id |
10.7–12.3 ng/mL |
6th day of administration = FET day |
31 VS 17% |
Labarta et al. (2019)2323 Labarta ED, Mariani G, Paolelli S, et al. O-173: A large prospective trial in unselected population confirms that low serum progesterone on the day of embryo transfer impairs pregnancy outcome in artificial cycles. Hum Reprod 2019;34 Suppl 1:82. Abstract Book - ESHRE 2019-Vienna, Austria, 2019 Jun 23-26. data from ESHRE congress abstract – Hum Reprod |
Spain |
Prospective |
1155 |
autologous and donors |
vitrified blastocysts |
vaginal 400 mg 2id |
> 8.8 ng/mL |
6th day of administration = FET day |
58 VS 40% |