Effect of subchorionic hematoma on first-trimester maternal serum free β-hCG and PAPP-A levels

Akay, Arife; Reis, Yıldız Akdaş; Şahin, Büşra; Öncü, Asya Kalaycı; Obut, Mehmet; İskender, Cantekin; Çelen, Şevki

doi:10.61622/rbgo/2024rbgo66

Arife Akay

were involved in the collection of data

design

and interpretation of the analysis

contributed to the writing of the manuscript

and read and approved the final manuscript

Etlik Zübeyde Hanım Maternity and Women’s Health Teaching and Research Hospital, Department of Obstetrics and Gynecology, Ankara, Turkey.

Bingöl State Hospital, Department of Obstetrics and Gynecology, Bingöl, Turkey.

https://orcid.org/0000-0001-9640-2714

Yıldız Akdaş Reis

were involved in the collection of data

design

and interpretation of the analysis

contributed to the writing of the manuscript

and read and approved the final manuscript

Etlik Zübeyde Hanım Maternity and Women’s Health Teaching and Research Hospital, Department of Obstetrics and Gynecology, Ankara, Turkey.

https://orcid.org/0000-0001-9345-6899

Büşra Şahin

were involved in the collection of data

design

and interpretation of the analysis

contributed to the writing of the manuscript

and read and approved the final manuscript

Etlik Zübeyde Hanım Maternity and Women’s Health Teaching and Research Hospital, Department of Obstetrics and Gynecology, Ankara, Turkey.

Akçakoca Public Hospital, Department of Obstetrics and Gynecology, Düzce, Turkey.

https://orcid.org/0000-0003-2420-6233

Asya Kalaycı Öncü

were involved in the collection of data

design

and interpretation of the analysis

contributed to the writing of the manuscript

and read and approved the final manuscript

Etlik Zübeyde Hanım Maternity and Women’s Health Teaching and Research Hospital, Department of Obstetrics and Gynecology, Ankara, Turkey.

Erciş Şehit Rıdvan Çevik Public Hospital, Van, Turkey.

https://orcid.org/0000-0001-8582-6175

Mehmet Obut

were involved in the collection of data

design

and interpretation of the analysis

contributed to the writing of the manuscript

and read and approved the final manuscript

Etlik Zübeyde Hanım Maternity and Women’s Health Teaching and Research Hospital, Department of Obstetrics and Gynecology, Ankara, Turkey.

Diyarbakir Gazi Yasargil Training and Research Hospital, Department of Perinatology, Diyarbakır, Turkey.

https://orcid.org/0000-0002-6925-4784

Cantekin İskender

were involved in the collection of data

design

and interpretation of the analysis

contributed to the writing of the manuscript

and read and approved the final manuscript

Etlik Zübeyde Hanım Maternity and Women’s Health Teaching and Research Hospital, Department of Obstetrics and Gynecology, Ankara, Turkey.

Etlik City Hospital, Department of Perinatology, Ankara, Turkey.

https://orcid.org/0000-0003-1376-5734

Şevki Çelen

were involved in the collection of data

design

and interpretation of the analysis

contributed to the writing of the manuscript

and read and approved the final manuscript

Etlik Zübeyde Hanım Maternity and Women’s Health Teaching and Research Hospital, Department of Obstetrics and Gynecology, Ankara, Turkey.

Etlik City Hospital, Department of Perinatology, Ankara, Turkey.

https://orcid.org/0000-0001-7033-3474

Corresponding author: Arife Akay E-mail: arifeakay@gmail.com

Conflicts to interest: none to declare.

Associate Editor: Maria Laura Costa do Nascimento (https://orcid.org/0000-0001-8280-3234) Universidade Estadual de Campinas, Campinas, SP, Brazil

Variables	Groups		p-value
	Study Group subchorionic hematoma + n=119	Control Group subchorionic hematoma - n=153
	Median (IQR)	Median (IQR)
Age	27(8)	27(9)	0.422
Number of gravidea	2(2)	2(2)	0.186
Number of parity	1(2)	1(2)	0.081
Number of previous abortions	0(0)	0(1)	0.655
Number of previous vaginal birth	0(2)	0(1)	0.097
Number of previous cesarean birth	0(0)	0(0)	0.904
Birth week	38.0(1.25)	39.0 (1.0)	0.011*
Gestational week at TM	11.0 (3.25)	11.0 (4)	0.476
Week of gestation in screening test	12.0(1)	12.0(1)	0.330
The thickness of NT (mm)	1.20(0.40)	1.20(0.60)	0.164
PAPP-A(ng/ml)	780.0(754)	701.8(748)	0.699
PAPP-A MoM	0.88(0.93)	0.90(0.63)	0.519
Free β-hCG (mUI/ml)	104919.0(78624)	99408.0(77051)	0.350
Free β-hCG MoM	1.04(0.78)	0.99(0.86)	0.662
Vertical length of SH (mm)	31.0(29.25)	-	-
Longitudinal length of SH (mm)	16(17)	-	-

Comparison		Groups		Total	p-value
Comparison		Study Group subchorionic hematoma + n(% within groups)	Control Group subchorionic hematoma – n(% within groups)	Total	p-value
Free β-hCG MoM	<0.5 MoM Low	9(7.6)	9(5.9)	18(6.6)	0.369
	0.5-2.5 MoM Normal	108(90.8)	137(89.5)	245(90.1)
	>2.5 MoM High	2(1.7)	7(4.6)	9(3.3)
PAPP-A MoM	<0.5 MoM Low	16(13.4)	22(14.4)	38(14.0)	0.962
	0.5-2.5 MoM Normal	98(82.4)	124(81.0)	222(81.6)
	>2.5 MoM High	5(4.2)	7(4.6)	12(4.4)
Total		119	153	272

Model		Coefficients			t	Sig.	95.0% confidence Interval for B
		Unstandardized coefficients		Standardized coefficients			95.0% confidence Interval for B
		B	Std. Error	Beta			Lower bound	Upper bound
PAPP-A MoM	(Constant)	1.697	0.418		4.063	<0.001	0.869	2.524
	Age	-0.014	0.014	-0.101	-1.010	0.315	-0.043	0.014
	Number of gravida	-0.015	0.051	-0.030	-0.301	0.764	-0.117	0.086
	The vertical length of subchorionic hematoma	-0.003	0.004	-0.091	-0.852	0.396	-0.011	0.004
	The longitudinal length of subchorionic hematoma	-0.004	0.005	-0.096	-0.902	0.369	-0.014	0.005
	Free β-hcg MoM	0.027	0.111	0.023	0.244	0.808	-0.192	0.246
free β-hCG MoM	(Constant)	1.600	0.351		4.560	<0.001	0.905	2.296
	Age	-0.022	0.012	-0.185	-1.870	0.064	-0.046	0.001
	Number of gravida	0.078	0.043	0.178	1.819	0.072	-0.007	0.164
	The vertical length of subchorionic hematoma	-0.002	0.003	-0.064	-0.595	0.553	-0.008	0.005
	The longitudinal length of subchorionic hematoma	0.002	0.004	0.056	0.526	0.600	-0.006	0.011
	PAPP-A MoM	0.020	0.081	0.023	0.244	0.808	-0.140	0.180

[1] Corresponding author: Arife Akay E-mail: arifeakay@gmail.com

Brasil

Brasil

Effect of subchorionic hematoma on first-trimester maternal serum free β-hCG and PAPP-A levels

Abstract

Objective

Methods

Results

Conclusion